KNApSAcK Metabolite C00028244
Metabolite
KNApSAcK Entry
| id | C00028244 |
|---|---|
| Name | CMI 488 / Epibatidine |
| CAS RN | 140111-52-0 |
| Standard InChI | InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8-,9+,10+/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2 |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 8088 |
Link
ChEMBL
| By standard InChI | CHEMBL298826 |
|---|---|
| By standard InChI Main Layer | CHEMBL6623 CHEMBL54902 CHEMBL298826 CHEMBL298517 CHEMBL306959 CHEMBL513692 |
KEGG
| By LinkDB | C11690 |
|---|
CTD
| By CAS RN | C082748 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Dendrobatidae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Epipedobates tricolr | 92727 | Dendrobatidae | Metazoa |
Human Protein / Gene in interaction
22 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL298517 |
CHEMBL1741321
(1)
|
1 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | CHEMBL6623 |
CHEMBL1794499
(1)
|
2 / 0 |
| P32297 | Neuronal acetylcholine receptor subunit alpha-3 | CHRN alpha | CHEMBL6623 |
CHEMBL752654
(1)
CHEMBL750052
(1)
CHEMBL750054 (1) CHEMBL842924 (1) CHEMBL881164 (1) CHEMBL830258 (1) CHEMBL830259 (1) CHEMBL840083 (1) CHEMBL826914 (2) CHEMBL827782 (1) CHEMBL908428 (1) CHEMBL914876 (1) CHEMBL914877 (1) CHEMBL899884 (2) CHEMBL899887 (1) CHEMBL964081 (1) CHEMBL964082 (1) CHEMBL1071136 (1) CHEMBL1099786 (1) CHEMBL1099787 (1) |
1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL298517 |
CHEMBL1741325
(1)
|
0 / 1 |
| P30926 | Neuronal acetylcholine receptor subunit beta-4 | CHRN beta | CHEMBL6623 |
CHEMBL752377
(1)
CHEMBL752654
(1)
CHEMBL750052 (1) CHEMBL750054 (1) CHEMBL750434 (1) CHEMBL830259 (1) CHEMBL826914 (2) CHEMBL826916 (2) CHEMBL827781 (1) CHEMBL908428 (1) CHEMBL914876 (1) CHEMBL914877 (1) CHEMBL899884 (2) CHEMBL899887 (1) CHEMBL1071136 (1) CHEMBL1099786 (1) CHEMBL1099787 (1) |
0 / 0 |
| Q07001 | Acetylcholine receptor subunit delta | CHRN delta | CHEMBL6623 |
CHEMBL834065
(1)
CHEMBL825304
(1)
|
3 / 2 |
| P43681 | Neuronal acetylcholine receptor subunit alpha-4 | CHRN alpha | CHEMBL6623 CHEMBL54902 CHEMBL298517 CHEMBL513692 |
CHEMBL750057
(1)
CHEMBL754719
(1)
CHEMBL755326 (1) CHEMBL756008 (1) CHEMBL751862 (1) CHEMBL751864 (1) CHEMBL751866 (1) CHEMBL750434 (1) CHEMBL826916 (2) CHEMBL827784 (1) CHEMBL838016 (1) CHEMBL825420 (1) CHEMBL908427 (1) CHEMBL890277 (2) CHEMBL899886 (2) CHEMBL899885 (1) CHEMBL901310 (1) CHEMBL924349 (1) CHEMBL1000467 (1) CHEMBL964079 (1) CHEMBL964080 (1) CHEMBL1071135 (1) CHEMBL2067156 (1) |
1 / 1 |
| P07510 | Acetylcholine receptor subunit gamma | CHRN gamma | CHEMBL6623 |
CHEMBL834065
(1)
CHEMBL825304
(1)
|
2 / 1 |
| P17787 | Neuronal acetylcholine receptor subunit beta-2 | CHRN beta | CHEMBL6623 CHEMBL54902 CHEMBL298517 |
CHEMBL750057
(1)
CHEMBL754719
(1)
CHEMBL755326 (1) CHEMBL756008 (1) CHEMBL751862 (1) CHEMBL751864 (1) CHEMBL751866 (1) CHEMBL830258 (1) CHEMBL840083 (1) CHEMBL827782 (1) CHEMBL827784 (1) CHEMBL838016 (1) CHEMBL825420 (1) CHEMBL908427 (1) CHEMBL890277 (2) CHEMBL899886 (2) CHEMBL899885 (1) CHEMBL901310 (1) CHEMBL924349 (1) CHEMBL1071135 (1) CHEMBL2067156 (1) |
1 / 1 |
| P02708 | Acetylcholine receptor subunit alpha | CHRN alpha | CHEMBL6623 |
CHEMBL834065
(1)
CHEMBL825304
(1)
|
3 / 2 |
| P11230 | Acetylcholine receptor subunit beta | CHRN beta | CHEMBL6623 |
CHEMBL834065
(1)
CHEMBL825304
(1)
|
2 / 1 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL6623 CHEMBL298517 |
CHEMBL1614458
(3)
|
0 / 0 |
| P36544 | Neuronal acetylcholine receptor subunit alpha-7 | CHRN alpha | CHEMBL6623 CHEMBL298517 |
CHEMBL750438
(1)
CHEMBL750446
(1)
CHEMBL751838 (1) CHEMBL830079 (1) CHEMBL830082 (1) CHEMBL953564 (2) |
0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL298517 |
CHEMBL1741322
(1)
|
0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | CHEMBL6623 |
CHEMBL1614038
(1)
|
2 / 2 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL298517 |
CHEMBL1741323
(1)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL298517 |
CHEMBL1741324
(1)
|
0 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL6623 |
CHEMBL1738442
(1)
|
0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | CHEMBL6623 |
CHEMBL1614364
(1)
|
1 / 1 |
| O00255 | Menin | Unclassified protein | CHEMBL298517 |
CHEMBL1614531
(1)
|
2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL298517 |
CHEMBL1614531
(1)
|
1 / 3 |
| Q15822 | Neuronal acetylcholine receptor subunit alpha-2 | CHRN alpha | CHEMBL6623 |
CHEMBL752377
(1)
CHEMBL827781
(1)
|
1 / 1 |
CTD interaction (54)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C082748 | 1135 |
CHRNA2
|
cholinergic receptor, nicotinic, alpha 2 (neuronal) | [CHRNB4 protein binds to CHRNA2 protein] which binds to epibatidine |
affects binding
|
protein |
9454827
|
| C082748 | 1136 |
CHRNA3
LNCR2 NACHRA3 PAOD2 |
cholinergic receptor, nicotinic, alpha 3 (neuronal) | [CHRNB4 protein binds to CHRNA3 protein] which binds to epibatidine |
affects binding
|
protein |
9454827
|
| C082748 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | Acetylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | Acetylthiocholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | Alcuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | Carbachol inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | Choline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | [CHRNB4 protein binds to CHRNA4 protein] which binds to epibatidine |
affects binding
|
protein |
9454827
|
| C082748 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | cytisine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | decamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | Dihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | Dimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein] |
affects binding
|
protein |
14645658
|
| C082748 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | epibatidine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein] |
affects binding
/ increases activity |
protein |
14645658
|
| C082748 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | Hexamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | Lobeline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | methyllycaconitine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | Nicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | Pancuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | Physostigmine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | subecholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1139 |
CHRNA7
CHRNA7-2 NACHRA7 |
cholinergic receptor, nicotinic, alpha 7 (neuronal) | Bungarotoxins inhibits the reaction [epibatidine binds to CHRNA7 protein] |
affects binding
/ decreases reaction |
protein |
21703337
|
| C082748 | 1139 |
CHRNA7
CHRNA7-2 NACHRA7 |
cholinergic receptor, nicotinic, alpha 7 (neuronal) | Carbachol inhibits the reaction [epibatidine binds to CHRNA7 protein] |
affects binding
/ decreases reaction |
protein |
21703337
|
| C082748 | 1139 |
CHRNA7
CHRNA7-2 NACHRA7 |
cholinergic receptor, nicotinic, alpha 7 (neuronal) | epibatidine binds to CHRNA7 protein |
affects binding
|
protein |
21703337
|
| C082748 | 1139 |
CHRNA7
CHRNA7-2 NACHRA7 |
cholinergic receptor, nicotinic, alpha 7 (neuronal) | methyllycaconitine inhibits the reaction [epibatidine binds to CHRNA7 protein] |
affects binding
/ decreases reaction |
protein |
21703337
|
| C082748 | 1139 |
CHRNA7
CHRNA7-2 NACHRA7 |
cholinergic receptor, nicotinic, alpha 7 (neuronal) | PNU-282987 inhibits the reaction [epibatidine binds to CHRNA7 protein] |
affects binding
/ decreases reaction |
protein |
21703337
|
| C082748 | 1139 |
CHRNA7
CHRNA7-2 NACHRA7 |
cholinergic receptor, nicotinic, alpha 7 (neuronal) | SAD-128 analog inhibits the reaction [epibatidine binds to CHRNA7 protein] |
affects binding
/ decreases reaction |
protein |
21703337
|
| C082748 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | Acetylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | Acetylthiocholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | Alcuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | Carbachol inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | Choline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | cytisine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | decamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | Dihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | Dimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein] |
affects binding
|
protein |
14645658
|
| C082748 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | epibatidine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein] |
affects binding
/ increases activity |
protein |
14645658
|
| C082748 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | Hexamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | Lobeline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | methyllycaconitine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | Nicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | Pancuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | Physostigmine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | subecholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| C082748 | 1143 |
CHRNB4
|
cholinergic receptor, nicotinic, beta 4 (neuronal) | [CHRNB4 protein binds to CHRNA2 protein] which binds to epibatidine |
affects binding
|
protein |
9454827
|
| C082748 | 1143 |
CHRNB4
|
cholinergic receptor, nicotinic, beta 4 (neuronal) | [CHRNB4 protein binds to CHRNA3 protein] which binds to epibatidine |
affects binding
|
protein |
9454827
|
| C082748 | 1143 |
CHRNB4
|
cholinergic receptor, nicotinic, beta 4 (neuronal) | [CHRNB4 protein binds to CHRNA4 protein] which binds to epibatidine |
affects binding
|
protein |
9454827
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (19)
| OMIM | preferred title | UniProt |
|---|---|---|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #600513 | Epilepsy, nocturnal frontal lobe, 1; enfl1 |
P43681
|
| #605375 | Epilepsy, nocturnal frontal lobe, 3; enfl3 |
P17787
|
| #610353 | Epilepsy, nocturnal frontal lobe, 4; enfl4 |
Q15822
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #265000 | Multiple pterygium syndrome, escobar variant; evmps |
P07510
|
| #253290 | Multiple pterygium syndrome, lethal type; lmps |
P02708
P07510 Q07001 |
| #608931 | Myasthenic syndrome, congenital, associated with acetylcholine receptor deficiency |
P11230
|
| #608930 | Myasthenic syndrome, congenital, fast-channel |
P02708
Q07001 |
| #601462 | Myasthenic syndrome, congenital, slow-channel; sccms |
P02708
P11230 Q07001 |
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #612052 | Smoking as a quantitative trait locus 3; sqtl3 |
P32297
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
KEGG DISEASE (16)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00770 | Congenital myasthenic syndrome |
P02708
(related)
P11230 (related) Q07001 (related) |
| H00986 | Multiple pterygium syndrome |
P02708
(related)
P07510 (related) Q07001 (related) |
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00807 | Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) |
P17787
(related)
P43681 (related) Q15822 (related) |
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|