PCIDB

Epipedobates tricolr

Species

KNApSAcK Entry

Organism name Epipedobates tricolr
Genus Epipedobates
Family Dendrobatidae
Kingdom Animalia

NCBI taxonomy

Entry

Linked NCBI taxonomy name Epipedobates
Linked NCBI taxonomy ID 92727
Linked level genus

Family

Family in NCBI taxonomy Dendrobatidae
ID 43469

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Metazoa
ID 33208

Plant class

Plant class
ID

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00028244 External link 512 CMI 488
/ Epibatidine
CHEMBL6623
CHEMBL54902
CHEMBL298826
CHEMBL298517
CHEMBL306959
CHEMBL513692
C082748
22 / 19 / 16 6 / 3 No. 8088

Human Protein / Gene in interactions

22 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00028244 1 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00028244 2 / 0
P32297 Neuronal acetylcholine receptor subunit alpha-3 CHRN alpha C00028244 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00028244 0 / 1
P30926 Neuronal acetylcholine receptor subunit beta-4 CHRN beta C00028244 0 / 0
Q07001 Acetylcholine receptor subunit delta CHRN delta C00028244 3 / 2
P43681 Neuronal acetylcholine receptor subunit alpha-4 CHRN alpha C00028244 1 / 1
P07510 Acetylcholine receptor subunit gamma CHRN gamma C00028244 2 / 1
P17787 Neuronal acetylcholine receptor subunit beta-2 CHRN beta C00028244 1 / 1
P02708 Acetylcholine receptor subunit alpha CHRN alpha C00028244 3 / 2
P11230 Acetylcholine receptor subunit beta CHRN beta C00028244 2 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00028244 0 / 0
P36544 Neuronal acetylcholine receptor subunit alpha-7 CHRN alpha C00028244 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00028244 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00028244 2 / 2
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00028244 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00028244 0 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00028244 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00028244 1 / 1
O00255 Menin Unclassified protein C00028244 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00028244 1 / 2
Q15822 Neuronal acetylcholine receptor subunit alpha-2 CHRN alpha C00028244 1 / 1

6 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1135 CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) C00028244
1136 CHRNA3, LNCR2, NACHRA3, PAOD2 cholinergic receptor, nicotinic, alpha 3 (neuronal) C00028244
1137 CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) C00028244
1139 CHRNA7, CHRNA7-2, NACHRA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) C00028244
1141 CHRNB2, EFNL3, nAChRB2 cholinergic receptor, nicotinic, beta 2 (neuronal) C00028244
1143 CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) C00028244

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (19)

OMIM preferred title UniProt
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600513 Epilepsy, nocturnal frontal lobe, 1; enfl1 P43681
#605375 Epilepsy, nocturnal frontal lobe, 3; enfl3 P17787
#610353 Epilepsy, nocturnal frontal lobe, 4; enfl4 Q15822
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#265000 Multiple pterygium syndrome, escobar variant; evmps P07510
#253290 Multiple pterygium syndrome, lethal type; lmps P02708
P07510
Q07001
#608931 Myasthenic syndrome, congenital, associated with acetylcholine receptor deficiency P11230
#608930 Myasthenic syndrome, congenital, fast-channel P02708
Q07001
#601462 Myasthenic syndrome, congenital, slow-channel; sccms P02708
P11230
Q07001
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#612052 Smoking as a quantitative trait locus 3; sqtl3 P32297
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8

KEGG DISEASE (16)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00770 Congenital myasthenic syndrome P02708 (related)
P11230 (related)
Q07001 (related)
H00986 Multiple pterygium syndrome P02708 (related)
P07510 (related)
Q07001 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00807 Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) P17787 (related)
P43681 (related)
Q15822 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

3 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006973 Hypertension C00028244
D054081 Neuronal Migration Disorders C00028244
D012640 Seizures C00028244