PCIDB

KCF-S cluster No. 8889 (1 metabolites)

Plant Species

Cumulative plant class count

class name count

Cumulative family count

class name count
Amanitaceae 2

KEGG BRITE br08003 External link 512

Categories (0)

br08003 Category # of metabolite

metabolites link (0)

br08003 Category KEGG ID KNApSAcK ID

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		figure
C00001423 External link 512 Muscimol
CHEMBL273481
D009118
29 / 16 / 14 2 / 33

Human Protein / Gene in interactions

29 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001423 1 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00001423 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001423 3 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001423 0 / 1
P24046 Gamma-aminobutyric acid receptor subunit rho-1 GABA-A rho C00001423 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001423 0 / 0
P28476 Gamma-aminobutyric acid receptor subunit rho-2 GABA-A rho C00001423 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001423 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001423 0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001423 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001423 0 / 0
O00255 Menin Unclassified protein C00001423 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001423 1 / 2
Q9UN88 Gamma-aminobutyric acid receptor subunit theta GABA-A theta C00001423 0 / 0
P28472 Gamma-aminobutyric acid receptor subunit beta-3 GABA-A beta C00001423 1 / 0
P14867 Gamma-aminobutyric acid receptor subunit alpha-1 GABA-A alpha C00001423 1 / 1
P48169 Gamma-aminobutyric acid receptor subunit alpha-4 GABA-A alpha C00001423 0 / 0
O14764 Gamma-aminobutyric acid receptor subunit delta GABA-A delta C00001423 1 / 1
P31644 Gamma-aminobutyric acid receptor subunit alpha-5 GABA-A alpha C00001423 0 / 0
Q99928 Gamma-aminobutyric acid receptor subunit gamma-3 GABA-A gamma C00001423 0 / 0
P78334 Gamma-aminobutyric acid receptor subunit epsilon GABA-A epsilon C00001423 0 / 0
Q8N1C3 Gamma-aminobutyric acid receptor subunit gamma-1 GABA-A gamma C00001423 0 / 0
P34903 Gamma-aminobutyric acid receptor subunit alpha-3 GABA-A alpha C00001423 0 / 0
O00591 Gamma-aminobutyric acid receptor subunit pi GABA-A pi C00001423 0 / 0
P47870 Gamma-aminobutyric acid receptor subunit beta-2 GABA-A beta C00001423 0 / 0
P18507 Gamma-aminobutyric acid receptor subunit gamma-2 GABA-A gamma C00001423 4 / 2
P18505 Gamma-aminobutyric acid receptor subunit beta-1 GABA-A beta C00001423 0 / 0
Q16445 Gamma-aminobutyric acid receptor subunit alpha-6 GABA-A alpha C00001423 0 / 0
P47869 Gamma-aminobutyric acid receptor subunit alpha-2 GABA-A alpha C00001423 1 / 0

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1138 CHRNA5, LNCR2 cholinergic receptor, nicotinic, alpha 5 (neuronal) C00001423
1140 CHRNB1, ACHRB, CHRNB, CMS1D, CMS2A, SCCMS cholinergic receptor, nicotinic, beta 1 (muscle) C00001423

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (16)

OMIM preferred title UniProt
#103780 Alcohol dependence P47869
#607208 Dravet syndrome P18507
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#607681 Epilepsy, childhood absence, susceptibility to, 2; eca2 P18507
#612269 Epilepsy, childhood absence, susceptibility to, 5; eca5 P28472
#613060 Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 O14764
#611136 Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 P14867
#604233 Generalized epilepsy with febrile seizures plus, type 1; gefsp1 P18507
#611277 Generalized epilepsy with febrile seizures plus, type 3; gefsp3 P18507
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#131100 Multiple endocrine neoplasia, type i; men1 O00255

KEGG DISEASE (14)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00783 Febrile seizures O14764 (related)
P18507 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00808 Idiopathic generalized epilepsies (IGEs) P14867 (related)
P18507 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)

Diseases related to CTD interactions

33 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000647 Amnesia C00001423
D001259 Ataxia C00001423
D001289 Attention Deficit Disorder with Hyperactivity C00001423
D001919 Bradycardia C00001423
D002545 Brain Ischemia C00001423
D002375 Catalepsy C00001423
D002389 Catatonia C00001423
D019970 Cocaine-Related Disorders C00001423
D004195 Disease Models, Animal C00001423
D004827 Epilepsy C00001423
D020329 Essential Tremor C00001423
D005334 Fever C00001423
D006930 Hyperalgesia C00001423
D006948 Hyperkinesis C00001423
D018476 Hypokinesia C00001423
D007859 Learning Disorders C00001423
D009123 Muscle Hypotonia C00001423
D009127 Muscle Rigidity C00001423
D009207 Myoclonus C00001423
D009436 Neural Tube Defects C00001423
D010146 Pain C00001423
D020734 Parkinsonian Disorders C00001423
D010409 Penile Diseases C00001423
D049188 Prenatal Injuries C00001423
D011605 Psychoses, Substance-Induced C00001423
D012559 Schizophrenia C00001423
D012640 Seizures C00001423
D013226 Status Epilepticus C00001423
D019956 Stereotypic Movement Disorder C00001423
D019966 Substance-Related Disorders C00001423
D013375 Substance Withdrawal Syndrome C00001423
D013610 Tachycardia C00001423
D053201 Urinary Bladder, Overactive C00001423