KNApSAcK Metabolite C00001423
Metabolite
KNApSAcK Entry
| id | C00001423 |
|---|---|
| Name | Muscimol |
| CAS RN | 2763-96-4 |
| Standard InChI | InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7) |
| Standard InChI (Main Layer) | InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 8889 |
Link
ChEMBL
| By standard InChI | CHEMBL273481 |
|---|---|
| By standard InChI Main Layer | CHEMBL273481 |
KEGG
| By LinkDB | C08311 |
|---|
CTD
| By CAS RN | D009118 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Amanitaceae | 2 |
List (2)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Amanita muscaria | 41956 | Amanitaceae | Fungi | |
| Amanita pantherina | 67721 | Amanitaceae | Fungi |
Human Protein / Gene in interaction
29 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL273481 |
CHEMBL1741321
(2)
|
1 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | CHEMBL273481 |
CHEMBL881969
(1)
|
0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | CHEMBL273481 |
CHEMBL1614281
(1)
CHEMBL1614361
(1)
|
3 / 2 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL273481 |
CHEMBL1741325
(2)
|
0 / 1 |
| P24046 | Gamma-aminobutyric acid receptor subunit rho-1 | GABA-A rho | CHEMBL273481 |
CHEMBL679669
(1)
CHEMBL964513
(1)
CHEMBL2317988 (2) CHEMBL2340049 (1) |
0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL273481 |
CHEMBL1741322
(2)
|
0 / 0 |
| P28476 | Gamma-aminobutyric acid receptor subunit rho-2 | GABA-A rho | CHEMBL273481 |
CHEMBL679668
(1)
|
0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL273481 |
CHEMBL1613777
(1)
CHEMBL1741323
(2)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL273481 |
CHEMBL1741324
(2)
|
0 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | CHEMBL273481 |
CHEMBL1614211
(1)
|
0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | CHEMBL273481 |
CHEMBL1613914
(1)
|
0 / 0 |
| O00255 | Menin | Unclassified protein | CHEMBL273481 |
CHEMBL1614531
(1)
|
2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL273481 |
CHEMBL1614531
(1)
|
1 / 3 |
| Q9UN88 | Gamma-aminobutyric acid receptor subunit theta | GABA-A theta | CHEMBL273481 |
CHEMBL681334
(1)
CHEMBL681949
(1)
CHEMBL681951 (1) |
0 / 0 |
| P28472 | Gamma-aminobutyric acid receptor subunit beta-3 | GABA-A beta | CHEMBL273481 |
CHEMBL681334
(1)
CHEMBL681949
(1)
CHEMBL681951 (1) |
1 / 0 |
| P14867 | Gamma-aminobutyric acid receptor subunit alpha-1 | GABA-A alpha | CHEMBL273481 |
CHEMBL681334
(1)
CHEMBL681949
(1)
CHEMBL681951 (1) |
1 / 1 |
| P48169 | Gamma-aminobutyric acid receptor subunit alpha-4 | GABA-A alpha | CHEMBL273481 |
CHEMBL681334
(1)
CHEMBL681949
(1)
CHEMBL681951 (1) |
0 / 0 |
| O14764 | Gamma-aminobutyric acid receptor subunit delta | GABA-A delta | CHEMBL273481 |
CHEMBL681334
(1)
CHEMBL681949
(1)
CHEMBL681951 (1) |
1 / 1 |
| P31644 | Gamma-aminobutyric acid receptor subunit alpha-5 | GABA-A alpha | CHEMBL273481 |
CHEMBL681334
(1)
CHEMBL681949
(1)
CHEMBL681951 (1) |
0 / 0 |
| Q99928 | Gamma-aminobutyric acid receptor subunit gamma-3 | GABA-A gamma | CHEMBL273481 |
CHEMBL681334
(1)
CHEMBL681949
(1)
CHEMBL681951 (1) |
0 / 0 |
| P78334 | Gamma-aminobutyric acid receptor subunit epsilon | GABA-A epsilon | CHEMBL273481 |
CHEMBL681334
(1)
CHEMBL681949
(1)
CHEMBL681951 (1) |
0 / 0 |
| Q8N1C3 | Gamma-aminobutyric acid receptor subunit gamma-1 | GABA-A gamma | CHEMBL273481 |
CHEMBL681334
(1)
CHEMBL681949
(1)
CHEMBL681951 (1) |
0 / 0 |
| P34903 | Gamma-aminobutyric acid receptor subunit alpha-3 | GABA-A alpha | CHEMBL273481 |
CHEMBL681334
(1)
CHEMBL681949
(1)
CHEMBL681951 (1) |
0 / 0 |
| O00591 | Gamma-aminobutyric acid receptor subunit pi | GABA-A pi | CHEMBL273481 |
CHEMBL681334
(1)
CHEMBL681949
(1)
CHEMBL681951 (1) |
0 / 0 |
| P47870 | Gamma-aminobutyric acid receptor subunit beta-2 | GABA-A beta | CHEMBL273481 |
CHEMBL681334
(1)
CHEMBL681949
(1)
CHEMBL681951 (1) |
0 / 0 |
| P18507 | Gamma-aminobutyric acid receptor subunit gamma-2 | GABA-A gamma | CHEMBL273481 |
CHEMBL681334
(1)
CHEMBL681949
(1)
CHEMBL681951 (1) |
4 / 2 |
| P18505 | Gamma-aminobutyric acid receptor subunit beta-1 | GABA-A beta | CHEMBL273481 |
CHEMBL681334
(1)
CHEMBL681949
(1)
CHEMBL681951 (1) |
0 / 0 |
| Q16445 | Gamma-aminobutyric acid receptor subunit alpha-6 | GABA-A alpha | CHEMBL273481 |
CHEMBL681334
(1)
CHEMBL681949
(1)
CHEMBL681951 (1) |
0 / 0 |
| P47869 | Gamma-aminobutyric acid receptor subunit alpha-2 | GABA-A alpha | CHEMBL273481 |
CHEMBL681334
(1)
CHEMBL681949
(1)
CHEMBL681951 (1) |
1 / 0 |
CTD interaction (2)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D009118 | 1138 |
CHRNA5
LNCR2 |
cholinergic receptor, nicotinic, alpha 5 (neuronal) | Muscimol binds to and results in increased activity of [CHRNA5 protein co-treated with CHRNB1 protein] |
affects binding
/ affects cotreatment / increases activity |
protein |
8388298
|
| D009118 | 1140 |
CHRNB1
ACHRB CHRNB CMS1D CMS2A SCCMS |
cholinergic receptor, nicotinic, beta 1 (muscle) | Muscimol binds to and results in increased activity of [CHRNA5 protein co-treated with CHRNB1 protein] |
affects binding
/ affects cotreatment / increases activity |
protein |
8388298
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (16)
| OMIM | preferred title | UniProt |
|---|---|---|
| #103780 | Alcohol dependence |
P47869
|
| #607208 | Dravet syndrome |
P18507
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #607681 | Epilepsy, childhood absence, susceptibility to, 2; eca2 |
P18507
|
| #612269 | Epilepsy, childhood absence, susceptibility to, 5; eca5 |
P28472
|
| #613060 | Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 |
O14764
|
| #611136 | Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 |
P14867
|
| #604233 | Generalized epilepsy with febrile seizures plus, type 1; gefsp1 |
P18507
|
| #611277 | Generalized epilepsy with febrile seizures plus, type 3; gefsp3 |
P18507
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
KEGG DISEASE (14)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00783 | Febrile seizures |
O14764
(related)
P18507 (related) |
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00808 | Idiopathic generalized epilepsies (IGEs) |
P14867
(related)
P18507 (related) |
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
Diseases related to CTD interactions
33 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D000647 | D009118 | Amnesia |
therapeutic
|
16319519
|
|
| D001259 | D009118 | Ataxia |
marker/mechanism
|
7189834
|
|
| D001289 | D009118 | Attention Deficit Disorder with Hyperactivity |
therapeutic
|
21277317
|
|
| D001919 | D009118 | Bradycardia |
marker/mechanism
therapeutic |
7189834
8583776 |
|
| D002545 | D009118 | Brain Ischemia |
therapeutic
|
9344559
|
|
| D002375 | D009118 | Catalepsy |
marker/mechanism
therapeutic |
33340
574045 3004539 3191399 3575168 6543001 7189827 8099716 |
|
| D002389 | D009118 | Catatonia |
marker/mechanism
|
2823166
7189834 |
|
| D019970 | D009118 | Cocaine-Related Disorders |
therapeutic
|
17291573
17650119 18455875 19879859 21108959 |
|
| D004195 | D009118 | Disease Models, Animal |
marker/mechanism
|
6118280
|
|
| D004827 | D009118 | Epilepsy |
therapeutic
|
4058572
|
|
| D020329 | D009118 | Essential Tremor |
therapeutic
|
19497322
|
|
| D005334 | D009118 | Fever |
therapeutic
|
12648744
|
|
| D006930 | D009118 | Hyperalgesia |
marker/mechanism
therapeutic |
9239313
17049512 |
|
| D006948 | D009118 | Hyperkinesis |
marker/mechanism
therapeutic |
6543001
11063919 12119450 |
|
| D018476 | D009118 | Hypokinesia |
marker/mechanism
|
7189834
|
|
| D007859 | D009118 | Learning Disorders |
marker/mechanism
|
19825423
|
|
| D009123 | D009118 | Muscle Hypotonia |
marker/mechanism
|
20347349
|
|
| D009127 | D009118 | Muscle Rigidity |
marker/mechanism
|
3004539
|
|
| D009207 | D009118 | Myoclonus |
marker/mechanism
|
6118280
|
|
| D009436 | D009118 | Neural Tube Defects |
marker/mechanism
|
11532198
|
|
| D010146 | D009118 | Pain |
therapeutic
|
6794090
|
|
| D020734 | D009118 | Parkinsonian Disorders |
therapeutic
|
569589
|
|
| D010409 | D009118 | Penile Diseases |
therapeutic
|
7862903
10704759 11906527 |
|
| D049188 | D009118 | Prenatal Injuries |
marker/mechanism
|
11532198
|
|
| D011605 | D009118 | Psychoses, Substance-Induced |
therapeutic
|
10840127
|
|
| D012559 | D009118 | Schizophrenia |
therapeutic
|
10840127
|
|
| D012640 | D009118 | Seizures |
therapeutic
|
1322322
1326092 1639237 2474871 2839355 2905779 3008043 3033555 7189834 7463050 7875556 8274150 8619239 10211593 11587709 12460246 16629370 19833150 20347349 |
|
| D013226 | D009118 | Status Epilepticus |
therapeutic
|
20347349
|
|
| D019956 | D009118 | Stereotypic Movement Disorder |
marker/mechanism
|
6543001
|
|
| D019966 | D009118 | Substance-Related Disorders |
therapeutic
|
3359231
|
|
| D013375 | D009118 | Substance Withdrawal Syndrome |
therapeutic
|
19150477
|
|
| D013610 | D009118 | Tachycardia |
therapeutic
|
8583776
12648744 |
|
| D053201 | D009118 | Urinary Bladder, Overactive |
therapeutic
|
6256670
|