Amanita pantherina
Species
KNApSAcK Entry
| Organism name | Amanita pantherina |
|---|---|
| Genus | Amanita |
| Family | Amanitaceae |
| Kingdom | Fungi |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Amanita pantherina |
|---|---|
| Linked NCBI taxonomy ID | 67721 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Amanitaceae |
|---|---|
| ID | 41954 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Fungi |
|---|---|
| ID | 4751 |
Plant class
| Plant class | |
|---|---|
| ID |
Metabolite list (2)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001423
|
Muscimol
|
CHEMBL273481
|
D009118
|
29 / 16 / 14 | 2 / 33 | No. 8889 |
|
|
|
C00002345
|
Ibotenic acid
|
CHEMBL284895
CHEMBL30285 |
D007051
|
19 / 18 / 23 | 0 / 7 | No. 8919 |
|
Human Protein / Gene in interactions
39 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001423 C00002345 | 1 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001423 C00002345 | 1 / 2 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001423 C00002345 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001423 C00002345 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001423 C00002345 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001423 C00002345 | 0 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001423 C00002345 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001423 C00002345 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00001423 C00002345 | 2 / 5 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002345 | 0 / 0 |
| Q14416 | Metabotropic glutamate receptor 2 | Metabotropic glutamate receptor | C00002345 | 0 / 0 |
| Q14833 | Metabotropic glutamate receptor 4 | Metabotropic glutamate receptor | C00002345 | 0 / 0 |
| Q13255 | Metabotropic glutamate receptor 1 | Metabotropic glutamate receptor | C00002345 | 1 / 0 |
| P28476 | Gamma-aminobutyric acid receptor subunit rho-2 | GABA-A rho | C00001423 | 0 / 0 |
| P24046 | Gamma-aminobutyric acid receptor subunit rho-1 | GABA-A rho | C00001423 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001423 | 3 / 2 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002345 | 11 / 10 |
| P41594 | Metabotropic glutamate receptor 5 | Metabotropic glutamate receptor | C00002345 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00001423 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00002345 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00002345 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00002345 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00002345 | 1 / 4 |
| Q9UN88 | Gamma-aminobutyric acid receptor subunit theta | GABA-A theta | C00001423 | 0 / 0 |
| P28472 | Gamma-aminobutyric acid receptor subunit beta-3 | GABA-A beta | C00001423 | 1 / 0 |
| P14867 | Gamma-aminobutyric acid receptor subunit alpha-1 | GABA-A alpha | C00001423 | 1 / 1 |
| P48169 | Gamma-aminobutyric acid receptor subunit alpha-4 | GABA-A alpha | C00001423 | 0 / 0 |
| O14764 | Gamma-aminobutyric acid receptor subunit delta | GABA-A delta | C00001423 | 1 / 1 |
| P31644 | Gamma-aminobutyric acid receptor subunit alpha-5 | GABA-A alpha | C00001423 | 0 / 0 |
| Q99928 | Gamma-aminobutyric acid receptor subunit gamma-3 | GABA-A gamma | C00001423 | 0 / 0 |
| P78334 | Gamma-aminobutyric acid receptor subunit epsilon | GABA-A epsilon | C00001423 | 0 / 0 |
| Q8N1C3 | Gamma-aminobutyric acid receptor subunit gamma-1 | GABA-A gamma | C00001423 | 0 / 0 |
| P34903 | Gamma-aminobutyric acid receptor subunit alpha-3 | GABA-A alpha | C00001423 | 0 / 0 |
| O00591 | Gamma-aminobutyric acid receptor subunit pi | GABA-A pi | C00001423 | 0 / 0 |
| P47870 | Gamma-aminobutyric acid receptor subunit beta-2 | GABA-A beta | C00001423 | 0 / 0 |
| P18507 | Gamma-aminobutyric acid receptor subunit gamma-2 | GABA-A gamma | C00001423 | 4 / 2 |
| P18505 | Gamma-aminobutyric acid receptor subunit beta-1 | GABA-A beta | C00001423 | 0 / 0 |
| Q16445 | Gamma-aminobutyric acid receptor subunit alpha-6 | GABA-A alpha | C00001423 | 0 / 0 |
| P47869 | Gamma-aminobutyric acid receptor subunit alpha-2 | GABA-A alpha | C00001423 | 1 / 0 |
2 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1138 | CHRNA5, LNCR2 | cholinergic receptor, nicotinic, alpha 5 (neuronal) |
C00001423
|
| 1140 | CHRNB1, ACHRB, CHRNB, CMS1D, CMS2A, SCCMS | cholinergic receptor, nicotinic, beta 1 (muscle) |
C00001423
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (29)
| OMIM | preferred title | UniProt |
|---|---|---|
| #103780 | Alcohol dependence |
P47869
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #607208 | Dravet syndrome |
P18507
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #607681 | Epilepsy, childhood absence, susceptibility to, 2; eca2 |
P18507
|
| #612269 | Epilepsy, childhood absence, susceptibility to, 5; eca5 |
P28472
|
| #613060 | Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 |
O14764
|
| #611136 | Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 |
P14867
|
| #604233 | Generalized epilepsy with febrile seizures plus, type 1; gefsp1 |
P18507
|
| #611277 | Generalized epilepsy with febrile seizures plus, type 3; gefsp3 |
P18507
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #614831 | Spinocerebellar ataxia, autosomal recessive 13; scar13 |
Q13255
|
KEGG DISEASE (27)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00783 | Febrile seizures |
O14764
(related)
P18507 (related) |
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00808 | Idiopathic generalized epilepsies (IGEs) |
P14867
(related)
P18507 (related) |
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
Diseases related to CTD interactions
38 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D000647 | Amnesia |
C00002345
C00001423 |
| D006948 | Hyperkinesis |
C00002345
C00001423 |
| D018476 | Hypokinesia |
C00001423
|
| D001930 | Brain Injuries |
C00002345
|
| D000544 | Alzheimer Disease |
C00002345
|
| D008569 | Memory Disorders |
C00002345
|
| D009422 | Nervous System Diseases |
C00002345
|
| D001259 | Ataxia |
C00001423
|
| D001289 | Attention Deficit Disorder with Hyperactivity |
C00001423
|
| D001919 | Bradycardia |
C00001423
|
| D002545 | Brain Ischemia |
C00001423
|
| D002375 | Catalepsy |
C00001423
|
| D002389 | Catatonia |
C00001423
|
| D019970 | Cocaine-Related Disorders |
C00001423
|
| D004195 | Disease Models, Animal |
C00001423
|
| D004827 | Epilepsy |
C00001423
|
| D020329 | Essential Tremor |
C00001423
|
| D005334 | Fever |
C00001423
|
| D006930 | Hyperalgesia |
C00001423
|
| D001927 | Brain Diseases |
C00002345
|
| D007859 | Learning Disorders |
C00001423
|
| D009123 | Muscle Hypotonia |
C00001423
|
| D009127 | Muscle Rigidity |
C00001423
|
| D009207 | Myoclonus |
C00001423
|
| D009436 | Neural Tube Defects |
C00001423
|
| D010146 | Pain |
C00001423
|
| D020734 | Parkinsonian Disorders |
C00001423
|
| D010409 | Penile Diseases |
C00001423
|
| D049188 | Prenatal Injuries |
C00001423
|
| D011605 | Psychoses, Substance-Induced |
C00001423
|
| D012559 | Schizophrenia |
C00001423
|
| D012640 | Seizures |
C00001423
|
| D013226 | Status Epilepticus |
C00001423
|
| D019956 | Stereotypic Movement Disorder |
C00001423
|
| D019966 | Substance-Related Disorders |
C00001423
|
| D013375 | Substance Withdrawal Syndrome |
C00001423
|
| D013610 | Tachycardia |
C00001423
|
| D053201 | Urinary Bladder, Overactive |
C00001423
|