PCIDB

KNApSAcK Metabolite C00002345

Metabolite

KNApSAcK Entry

id C00002345
Name Ibotenic acid
CAS RN 2552-55-8
Standard InChI InChI=1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)
Standard InChI (Main Layer) InChI=1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)

Cluster

Phytochemical cluster
KCF-S cluster No. 8919

Link

ChEMBL

By standard InChI CHEMBL284895
By standard InChI Main Layer CHEMBL284895 CHEMBL30285

KEGG

By LinkDB C10600

CTD

By CAS RN D007051

Species

Summary

Plant class

class name count

Family

family name count
Amanitaceae 2

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Amanita muscaria 41956 Amanitaceae Fungi
Amanita pantherina 67721 Amanitaceae Fungi

Human Protein / Gene in interaction

19 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL30285 CHEMBL1741321 (1)
1 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL284895 CHEMBL1738312 (1)
0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL284895 CHEMBL2114744 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL284895 CHEMBL1614544 (1)
11 / 10
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL30285 CHEMBL1741325 (1)
0 / 1
Q14416 Metabotropic glutamate receptor 2 Metabotropic glutamate receptor CHEMBL284895 CHEMBL718215 (1) CHEMBL820027 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL284895 CHEMBL1794401 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL30285 CHEMBL1741322 (1)
0 / 0
Q14833 Metabotropic glutamate receptor 4 Metabotropic glutamate receptor CHEMBL284895 CHEMBL716502 (1) CHEMBL818788 (1)
0 / 0
Q13255 Metabotropic glutamate receptor 1 Metabotropic glutamate receptor CHEMBL284895 CHEMBL30285 CHEMBL719076 (1) CHEMBL717335 (1)
1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL30285 CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL30285 CHEMBL1741324 (1)
0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL30285 CHEMBL1614211 (1)
0 / 0
P41594 Metabotropic glutamate receptor 5 Metabotropic glutamate receptor CHEMBL284895 CHEMBL711712 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL30285 CHEMBL1613914 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL30285 CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL30285 CHEMBL1614531 (1)
1 / 3
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL284895 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL284895 CHEMBL1613933 (1)
1 / 6

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (18)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#614831 Spinocerebellar ataxia, autosomal recessive 13; scar13 Q13255

KEGG DISEASE (23)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)

Diseases related to CTD interactions

7 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000544 D007051 Alzheimer Disease marker/mechanism
9449054
D000647 D007051 Amnesia marker/mechanism
12650838
D001927 D007051 Brain Diseases marker/mechanism
7903225
D001930 D007051 Brain Injuries marker/mechanism
3513907
12650838
D006948 D007051 Hyperkinesis marker/mechanism
8026079
D008569 D007051 Memory Disorders marker/mechanism
8968367
9449054
D009422 D007051 Nervous System Diseases marker/mechanism
8026079