PCIDB

Amanita muscaria

Species

KNApSAcK Entry

Organism name Amanita muscaria
Genus Amanita
Family Amanitaceae
Kingdom Fungi

NCBI taxonomy

Entry

Linked NCBI taxonomy name Amanita muscaria
Linked NCBI taxonomy ID 41956
Linked level species

Family

Family in NCBI taxonomy Amanitaceae
ID 41954

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Fungi
ID 4751

Plant class

Plant class
ID

Natural Activity

List (6)

Species Activity
Amanita muscaria GABA-Antagonist
Amanita muscaria Hallucinogen
Amanita muscaria Paralytic
Amanita muscaria Psychotropic
Amanita muscaria Stimulant
Amanita muscaria toxic

Metabolite list (9)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00001152 External link 512 Trehalose
D014199
No. 423 No. 73
C00001602 External link 512 Muscapurpurin
No. 4567 No. 71
C00001600 External link 512 Musca-aurin-II
No. 4567 No. 71
C00027602 External link 512 (-)-allo-Muscarine
CHEMBL12587
CHEMBL105471
CHEMBL404094
CHEMBL1180201
12 / 8 / 5 No. 5425
C00001422 External link 512 Muscarine
CHEMBL12587
CHEMBL105471
CHEMBL404094
CHEMBL1180201
D009116
12 / 8 / 5 0 / 1 No. 5425
C00001599 External link 512 Musca-aurin-I
No. 7057 No. 71
C00001601 External link 512 Musca-aurin VII
No. 8118 No. 71
C00001423 External link 512 Muscimol
CHEMBL273481
D009118
29 / 16 / 14 2 / 33 No. 8889
C00002345 External link 512 Ibotenic acid
CHEMBL284895
CHEMBL30285
D007051
19 / 18 / 23 0 / 7 No. 8919

Human Protein / Gene in interactions

45 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001422 C00001423 C00002345 C00027602 1 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001422 C00001423 C00002345 C00027602 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001422 C00001423 C00002345 C00027602 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001422 C00001423 C00002345 C00027602 0 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001422 C00001423 C00002345 C00027602 0 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00001422 C00001423 C00027602 3 / 2
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00001422 C00027602 2 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001423 C00002345 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001422 C00027602 0 / 0
O00255 Menin Unclassified protein C00001423 C00002345 2 / 5
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001423 C00002345 0 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00001422 C00027602 0 / 0
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00001422 C00027602 1 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001423 C00002345 1 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001422 C00027602 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00001422 C00027602 0 / 0
P41594 Metabotropic glutamate receptor 5 Metabotropic glutamate receptor C00002345 0 / 0
Q13255 Metabotropic glutamate receptor 1 Metabotropic glutamate receptor C00002345 1 / 0
P28476 Gamma-aminobutyric acid receptor subunit rho-2 GABA-A rho C00001423 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00002345 0 / 0
Q14416 Metabotropic glutamate receptor 2 Metabotropic glutamate receptor C00002345 0 / 0
P24046 Gamma-aminobutyric acid receptor subunit rho-1 GABA-A rho C00001423 0 / 0
Q14833 Metabotropic glutamate receptor 4 Metabotropic glutamate receptor C00002345 0 / 0
P02545 Prelamin-A/C Unclassified protein C00002345 11 / 10
P33765 Adenosine receptor A3 Adenosine receptor C00001423 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00002345 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00002345 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00002345 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00002345 1 / 4
Q9UN88 Gamma-aminobutyric acid receptor subunit theta GABA-A theta C00001423 0 / 0
P28472 Gamma-aminobutyric acid receptor subunit beta-3 GABA-A beta C00001423 1 / 0
P14867 Gamma-aminobutyric acid receptor subunit alpha-1 GABA-A alpha C00001423 1 / 1
P48169 Gamma-aminobutyric acid receptor subunit alpha-4 GABA-A alpha C00001423 0 / 0
O14764 Gamma-aminobutyric acid receptor subunit delta GABA-A delta C00001423 1 / 1
P31644 Gamma-aminobutyric acid receptor subunit alpha-5 GABA-A alpha C00001423 0 / 0
Q99928 Gamma-aminobutyric acid receptor subunit gamma-3 GABA-A gamma C00001423 0 / 0
P78334 Gamma-aminobutyric acid receptor subunit epsilon GABA-A epsilon C00001423 0 / 0
Q8N1C3 Gamma-aminobutyric acid receptor subunit gamma-1 GABA-A gamma C00001423 0 / 0
P34903 Gamma-aminobutyric acid receptor subunit alpha-3 GABA-A alpha C00001423 0 / 0
O00591 Gamma-aminobutyric acid receptor subunit pi GABA-A pi C00001423 0 / 0
P47870 Gamma-aminobutyric acid receptor subunit beta-2 GABA-A beta C00001423 0 / 0
P18507 Gamma-aminobutyric acid receptor subunit gamma-2 GABA-A gamma C00001423 4 / 2
P18505 Gamma-aminobutyric acid receptor subunit beta-1 GABA-A beta C00001423 0 / 0
Q16445 Gamma-aminobutyric acid receptor subunit alpha-6 GABA-A alpha C00001423 0 / 0
P47869 Gamma-aminobutyric acid receptor subunit alpha-2 GABA-A alpha C00001423 1 / 0

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1138 CHRNA5, LNCR2 cholinergic receptor, nicotinic, alpha 5 (neuronal) C00001423
1140 CHRNB1, ACHRB, CHRNB, CMS1D, CMS2A, SCCMS cholinergic receptor, nicotinic, beta 1 (muscle) C00001423

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (31)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P47869
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#607208 Dravet syndrome P18507
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#607681 Epilepsy, childhood absence, susceptibility to, 2; eca2 P18507
#612269 Epilepsy, childhood absence, susceptibility to, 5; eca5 P28472
#613060 Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 O14764
#611136 Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 P14867
#604233 Generalized epilepsy with febrile seizures plus, type 1; gefsp1 P18507
#611277 Generalized epilepsy with febrile seizures plus, type 3; gefsp3 P18507
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#614831 Spinocerebellar ataxia, autosomal recessive 13; scar13 Q13255

KEGG DISEASE (27)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00783 Febrile seizures O14764 (related)
P18507 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00808 Idiopathic generalized epilepsies (IGEs) P14867 (related)
P18507 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)

Diseases related to CTD interactions

38 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000647 Amnesia C00002345
C00001423
D019966 Substance-Related Disorders C00001422
C00001423
D006948 Hyperkinesis C00002345
C00001423
D006930 Hyperalgesia C00001423
D001927 Brain Diseases C00002345
D008569 Memory Disorders C00002345
D009422 Nervous System Diseases C00002345
D000544 Alzheimer Disease C00002345
D001259 Ataxia C00001423
D001289 Attention Deficit Disorder with Hyperactivity C00001423
D001919 Bradycardia C00001423
D002545 Brain Ischemia C00001423
D002375 Catalepsy C00001423
D002389 Catatonia C00001423
D019970 Cocaine-Related Disorders C00001423
D004195 Disease Models, Animal C00001423
D004827 Epilepsy C00001423
D020329 Essential Tremor C00001423
D005334 Fever C00001423
D001930 Brain Injuries C00002345
D018476 Hypokinesia C00001423
D007859 Learning Disorders C00001423
D009123 Muscle Hypotonia C00001423
D009127 Muscle Rigidity C00001423
D009207 Myoclonus C00001423
D009436 Neural Tube Defects C00001423
D010146 Pain C00001423
D020734 Parkinsonian Disorders C00001423
D010409 Penile Diseases C00001423
D049188 Prenatal Injuries C00001423
D011605 Psychoses, Substance-Induced C00001423
D012559 Schizophrenia C00001423
D012640 Seizures C00001423
D013226 Status Epilepticus C00001423
D019956 Stereotypic Movement Disorder C00001423
D013375 Substance Withdrawal Syndrome C00001423
D013610 Tachycardia C00001423
D053201 Urinary Bladder, Overactive C00001423