KCF-S cluster No. 916 (10 metabolites)

Corresponding Phytochemical cluster No. 11

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (10)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	18
eudicotyledons	2
Liliopsida	1

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Cumulative family count

class name	count
Apocynaceae	18
Buxaceae	2
Amaryllidaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Steroid alkaloids	3

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metabolites link (3)

br08003 Category	KEGG ID	KNApSAcK ID
Steroid alkaloids	C06545	C00002243
Steroid alkaloids	C10810	C00002252
Steroid alkaloids	C10813	C00002254

Metabolite list (10)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002243	Conessine	CHEMBL191703 CHEMBL1319348 CHEMBL1591357	C007111	16 / 6 / 6
C00002252	Irehine
C00002254	Kurchessine	CHEMBL344384		1 / 1 / 0
C00025506	Holaphyllidine
C00025507	Holaphyllinol
C00025511	Holarrheline
C00028718	Norconessine	CHEMBL371125
C00028789	Pachyaximine A	CHEMBL342394		3 / 3 / 3
C00030488	Holadysenterine
C00030521	Isoconessimine	CHEMBL371125

Human Protein / Gene in interactions

19 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P22303	Acetylcholinesterase	Hydrolase	C00002254 C00028789	1 / 0
Q9H3N8	Histamine H4 receptor	Histamine receptor	C00002243	0 / 0
Q9Y5N1	Histamine H3 receptor	Histamine receptor	C00002243	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00002243	3 / 2
P25021	Histamine H2 receptor	Histamine receptor	C00002243	0 / 0
P35367	Histamine H1 receptor	Histamine receptor	C00002243	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00002243	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00002243	0 / 1
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00002243	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00002243	1 / 1
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00002243	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00002243	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00002243	1 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00002243	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00002243	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002243	0 / 1
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00002243	0 / 0
Q15125	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	Enzyme	C00028789	1 / 1
Q9UBM7	7-dehydrocholesterol reductase	Enzyme	C00028789	1 / 2

Related Diseases

Diseases related to proteins in ChEMBL interactions