PCIDB

KNApSAcK Metabolite C00002243

Metabolite

KNApSAcK Entry

id C00002243
Name Conessine
CAS RN 546-06-5
Standard InChI InChI=1S/C24H40N2/c1-16-20-8-9-22-19-7-6-17-14-18(25(3)4)10-12-23(17,2)21(19)11-13-24(20,22)15-26(16)5/h6,16,18-22H,7-15H2,1-5H3/t16-,18-,19+,20+,21-,22-,23-,24-/m0/s1
Standard InChI (Main Layer) InChI=1S/C24H40N2/c1-16-20-8-9-22-19-7-6-17-14-18(25(3)4)10-12-23(17,2)21(19)11-13-24(20,22)15-26(16)5/h6,16,18-22H,7-15H2,1-5H3

Cluster

Phytochemical cluster No. 11
KCF-S cluster No. 916

Link

ChEMBL

By standard InChI CHEMBL191703
By standard InChI Main Layer CHEMBL191703 CHEMBL1319348 CHEMBL1591357

KEGG

By LinkDB C06545

CTD

By CAS RN C007111

Human Protein / Gene in interaction

16 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1319348 CHEMBL1741321 (1)
1 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL1319348 CHEMBL2114784 (1)
1 / 1
Q9Y5N1 Histamine H3 receptor Histamine receptor CHEMBL191703 CHEMBL973670 (2) CHEMBL973672 (1)
CHEMBL973683 (1) CHEMBL973685 (1)
CHEMBL973687 (1) CHEMBL963037 (1)
CHEMBL1036178 (2)
0 / 0
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL191703 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
P25021 Histamine H2 receptor Histamine receptor CHEMBL191703 CHEMBL973675 (1)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL191703 CHEMBL973674 (1)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL191703 CHEMBL973677 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1319348 CHEMBL1741325 (1)
0 / 1
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL191703 CHEMBL973678 (1)
0 / 0
Q9H3N8 Histamine H4 receptor Histamine receptor CHEMBL191703 CHEMBL973676 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL1319348 CHEMBL1794467 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1319348 CHEMBL1741322 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL191703 CHEMBL1614240 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1319348 CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1319348 CHEMBL1741324 (1)
0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL191703 CHEMBL1614211 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (6)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (6)

KEGG disease name UniProt
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)