Species

KNApSAcK Entry

Organism name Holarrhena africana
Genus Holarrhena
Family Apocynaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Holarrhena
Linked NCBI taxonomy ID 69380
Linked level genus

Family

Family in NCBI taxonomy Apocynaceae
ID 4056

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002243 External link 512 Conessine
CHEMBL191703
CHEMBL1319348
CHEMBL1591357
C007111
16 / 6 / 6 No. 916 No. 11

Human Protein / Gene in interactions

16 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002243 1 / 0
Q99700 Ataxin-2 Unclassified protein C00002243 1 / 1
Q9Y5N1 Histamine H3 receptor Histamine receptor C00002243 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00002243 3 / 2
P25021 Histamine H2 receptor Histamine receptor C00002243 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00002243 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00002243 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002243 0 / 1
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00002243 0 / 0
Q9H3N8 Histamine H4 receptor Histamine receptor C00002243 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002243 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002243 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00002243 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002243 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002243 0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002243 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (6)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (6)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)