Holarrhena pubescens
Species
KNApSAcK Entry
| Organism name | Holarrhena pubescens |
|---|---|
| Genus | Holarrhena |
| Family | Apocynaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Holarrhena pubescens |
|---|---|
| Linked NCBI taxonomy ID | 69381 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Apocynaceae |
|---|---|
| ID | 4056 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Natural Activity
List (24)
| Species | Activity |
|---|---|
| Holarrhena pubescens Wall. Ex G. Don | Amebicide |
| Holarrhena pubescens Wall. Ex G. Don | Anesthetic |
| Holarrhena pubescens Wall. Ex G. Don | Anthelminthic |
| Holarrhena pubescens Wall. Ex G. Don | Antidysenteric |
| Holarrhena pubescens Wall. Ex G. Don | Antiinflammatory |
| Holarrhena pubescens Wall. Ex G. Don | Antipyretic |
| Holarrhena pubescens Wall. Ex G. Don | Antispasmodic |
| Holarrhena pubescens Wall. Ex G. Don | Antitubercular |
| Holarrhena pubescens Wall. Ex G. Don | Antiviral |
| Holarrhena pubescens Wall. Ex G. Don | Aperitif |
| Holarrhena pubescens Wall. Ex G. Don | Aphrodisiac |
| Holarrhena pubescens Wall. Ex G. Don | Astringent |
| Holarrhena pubescens Wall. Ex G. Don | Cardiodepressant |
| Holarrhena pubescens Wall. Ex G. Don | Carminative |
| Holarrhena pubescens Wall. Ex G. Don | Diuretic |
| Holarrhena pubescens Wall. Ex G. Don | Hypoglycemic |
| Holarrhena pubescens Wall. Ex G. Don | Hypotensive |
| Holarrhena pubescens Wall. Ex G. Don | Lactagogue |
| Holarrhena pubescens Wall. Ex G. Don | Narcotic |
| Holarrhena pubescens Wall. Ex G. Don | Protisticide |
| Holarrhena pubescens Wall. Ex G. Don | Stomachic |
| Holarrhena pubescens Wall. Ex G. Don | Tonic |
| Holarrhena pubescens Wall. Ex G. Don | Vasodilator |
| Holarrhena pubescens Wall. Ex G. Don | Vulnerary |
Metabolite list (2)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002243
|
Conessine
|
CHEMBL191703
CHEMBL1319348 CHEMBL1591357 |
C007111
|
16 / 6 / 6 | No. 916 | No. 11 |
|
|
|
C00002254
|
Kurchessine
|
CHEMBL344384
|
1 / 1 / 0 | No. 916 | No. 11 |
|
Human Protein / Gene in interactions
17 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002243 | 1 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002243 | 1 / 1 |
| Q9Y5N1 | Histamine H3 receptor | Histamine receptor | C00002243 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00002243 | 3 / 2 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00002243 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00002243 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00002243 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002243 | 0 / 1 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00002243 | 0 / 0 |
| Q9H3N8 | Histamine H4 receptor | Histamine receptor | C00002243 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002243 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002243 | 0 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00002254 | 1 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00002243 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002243 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002243 | 0 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00002243 | 0 / 0 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (7)
| OMIM | preferred title | UniProt |
|---|---|---|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (6)
| KEGG | name | UniProt |
|---|---|---|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|