Species

KNApSAcK Entry

Organism name Swietenia mahogani
Genus Swietenia
Family Meliaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Swietenia mahagoni
Linked NCBI taxonomy ID 459165
Linked level species

Family

Family in NCBI taxonomy Meliaceae
ID 43707

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (12)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00030459 External link 512 Hederagenin
CHEMBL486400
CHEMBL492472
CHEMBL1436053
C025763
7 / 11 / 11 No. 13 No. 51
C00034762 External link 512 2-Hydroxy-3-O-tigloylswietenolide
No. 102
C00003650 External link 512 Cycloartenol
CHEMBL119938
CHEMBL225815
CHEMBL226036
CHEMBL393145
CHEMBL2007217
C100089
0 / 1 No. 129 No. 11
C00034777 External link 512 7-Ketogedunin
/ 7-Deacetoxy-7-oxogedunin
CHEMBL374788
CHEMBL452232
CHEMBL1512460
6 / 13 / 43 No. 204 No. 51
C00034898 External link 512 Swietephragmin B
No. 378
C00034897 External link 512 Swietephragmin A
No. 378
C00034903 External link 512 Swietephragmin G
No. 378
C00034899 External link 512 Swietephragmin C
No. 378
C00034902 External link 512 Swietephragmin F
No. 378
C00034901 External link 512 Swietephragmin E
No. 378
C00034900 External link 512 Swietephragmin D
No. 378
C00034874 External link 512 Methyl 6-hydroxyangolensate
/ (-)-Methyl 6-hydroxyangolensate
CHEMBL513679
CHEMBL1080703
CHEMBL1170898
CHEMBL1561374
2 / 0 / 1 No. 1249

Human Protein / Gene in interactions

11 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00030459 C00034777 C00034874 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00030459 C00034777 C00034874 0 / 1
P15559 NAD(P)H dehydrogenase [quinone] 1 Enzyme C00030459 0 / 0
P02545 Prelamin-A/C Unclassified protein C00030459 11 / 10
P08047 Transcription factor Sp1 Unclassified protein C00030459 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00030459 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00034777 2 / 3
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00034777 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00034777 7 / 37
P10636 Microtubule-associated protein tau Unclassified protein C00034777 4 / 3
Q9UBT6 DNA polymerase kappa Enzyme C00030459 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (24)

OMIM preferred title UniProt
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (53)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D012878 Skin Neoplasms C00003650