Species

KNApSAcK Entry

Organism name Poria cocos
Genus
Family
Kingdom

NCBI taxonomy

Entry

Linked NCBI taxonomy name Wolfiporia cocos
Linked NCBI taxonomy ID 81056
Linked level species

Family

Family in NCBI taxonomy Coriolaceae
ID 83233

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Fungi
ID 4751

Plant class

Plant class
ID

Metabolite list (27)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00023810 External link 512 3-O-Acetyltumulosic acid
CHEMBL468034
C102487
No. 86 No. 51
C00047651 External link 512 25-Hydroxy-3-epitumulosic acid
/ (+)-25-Hydroxy-3-epitumulosic acid
No. 86 No. 51
C00023799 External link 512 Eburicoic acid
CHEMBL179188
CHEMBL1981478
C004867
0 / 1 No. 86 No. 51
C00047644 External link 512 16alpha-Hydroxyeburiconic acid
CHEMBL1077754
No. 86 No. 51
C00023800 External link 512 Tumulosic acid
CHEMBL461484
No. 86 No. 51
C00023782 External link 512 3beta-Hydroxylanosta-7,9(11),24-trien-21-oic acid
CHEMBL226995
CHEMBL2203608
No. 91
C00003652 External link 512 Ergosterol
/ Ergosta-5,7,22-trien-3beta-ol
CHEMBL222608
CHEMBL1232562
CHEMBL1512075
CHEMBL1741735
CHEMBL1965225
D004875
12 / 14 / 11 No. 111 No. 11
C00023804 External link 512 Dehydrotumulosic acid
CHEMBL517584
CHEMBL465312
C102488
No. 551
C00030104 External link 512 Dehydropachymic acid
CHEMBL226527
CHEMBL2203609
No. 551
C00047676 External link 512 5alpha,8alpha-Peroxydehydrotumulosic acid
/ (+)-5alpha,8alpha-Peroxydehydrotumulosic acid
CHEMBL226575
CHEMBL1078248
No. 551
C00023803 External link 512 Dehydroeburicoic acid
CHEMBL1744446
No. 551
C00023801 External link 512 Polyporenic acid C
CHEMBL461276
C476268
No. 551
C00045180 External link 512 3-Epidehydrotumulosic Acid
CHEMBL517584
CHEMBL465312
No. 551
C00044055 External link 512 3beta-p-Hydroxybenzoyldehydrotumulosic acid
No. 551
C00043842 External link 512 Poricoic acid H
/ (+)-Poricoic acid H
CHEMBL251767
No. 562
C00043841 External link 512 Poricoic acid G
/ (+)-Poricoic acid G
CHEMBL138450
No. 562
C00048069 External link 512 Poricoic acid HM
/ (-)-Poricoic acid HM
CHEMBL1078422
No. 562
C00045382 External link 512 Poricoic acid B
CHEMBL456872
No. 562
C00040062 External link 512 Poricoic acid DM
/ (+)-Poricoic acid DM
CHEMBL427415
CHEMBL1078556
No. 562
C00040061 External link 512 Poricoic acid CM
/ (+)-Poricoic acid CM
CHEMBL374393
No. 562
C00047652 External link 512 25-Hydroxyporicoic acid C
/ (-)-25-Hydroxyporicoic acid C
CHEMBL1078371
No. 562
C00048068 External link 512 Poricoic acid GM
/ (-)-Poricoic acid GM
CHEMBL1079200
No. 562
C00047654 External link 512 26-Hydroxyporicoic acid DM
/ (+)-26-Hydroxyporicoic acid DM
CHEMBL1078650
No. 562
C00040060 External link 512 Poricoic acid AM
/ (+)-Poricoic acid AM
CHEMBL389661
CHEMBL1078179
No. 562
C00047680 External link 512 6,7-Dehydroporicoic acid H
/ (-)-6,7-Dehydroporicoic acid H
CHEMBL1078423
No. 562
C00047653 External link 512 25-Methoxyporicoic acid A
/ (+)-25-Methoxyporicoic acid A
CHEMBL1078640
No. 562
C00045291 External link 512 Dehydroabietic acid methyl ester
/ (+)-Dehydroabietic acid methyl ester
CHEMBL12798
No. 2322

Human Protein / Gene in interactions

12 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003652 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003652 0 / 1
P11473 Vitamin D3 receptor NR1I1 C00003652 2 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00003652 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00003652 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003652 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00003652 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003652 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003652 0 / 1
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00003652 5 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00003652 4 / 3
P31939 Bifunctional purine biosynthesis protein PURH Enzyme C00003652 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (14)

OMIM preferred title UniProt
#608688 Aicar transformylase/imp cyclohydrolase deficiency P31939
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#218800 Crigler-najjar syndrome, type i P22309
#606785 Crigler-najjar syndrome, type ii P22309
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#143500 Gilbert syndrome P22309
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (11)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00966 AICA-ribosiduria P31939 (related)
H01171 Poor drug metabolism (PM) P33261 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D005909 Glioblastoma C00023799