Species

KNApSAcK Entry

Organism name Ganoderma applanatum
Genus Ganoderma
Family Ganodermataceae
Kingdom Fungi

NCBI taxonomy

Entry

Linked NCBI taxonomy name Ganoderma applanatum
Linked NCBI taxonomy ID 29884
Linked level species

Family

Family in NCBI taxonomy Ganodermataceae
ID 5313

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Fungi
ID 4751

Plant class

Plant class
ID

Metabolite list (18)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00023791 External link 512 Alnusenone
/ Friedoolean-5-en-3-one
CHEMBL517609
1 / 0 / 0 No. 13 No. 51
C00030354 External link 512 Ganoderic acid AP3
/ (+)-Ganoderic acid AP3
No. 55
C00030349 External link 512 Ganoderenic acid A
CHEMBL1922171
C118637
1 / 0 / 0 No. 55
C00030350 External link 512 Ganoderenic acid B
CHEMBL2205010
No. 55
C00030352 External link 512 Ganoderenic acid G
/ (+)-Ganoderenic acid G
No. 55
C00030351 External link 512 Ganoderenic acid D
CHEMBL1922179
1 / 0 / 0 No. 55
C00003747 External link 512 Friedelin
/ Friedeline
/ Friedelanone
/ (-)-Friedelin
/ Friedelan-3-one
CHEMBL485998
CHEMBL1551590
C060796
2 / 0 / 0 No. 101 No. 52
C00003652 External link 512 Ergosterol
/ Ergosta-5,7,22-trien-3beta-ol
CHEMBL222608
CHEMBL1232562
CHEMBL1512075
CHEMBL1741735
CHEMBL1965225
D004875
12 / 14 / 11 No. 111 No. 11
C00023765 External link 512 Ergosta-7,22-dien-3-one
/ (24S)24-Methylcholesta-7,22-dien-3-one
CHEMBL516711
CHEMBL1514671
C059439
1 / 0 / 1 No. 111 No. 11
C00023754 External link 512 5,6-Dehydroergosterol
/ Ergosta-7,22-dien-3beta-ol
/ 24-Methylcholesta-7,22-dien-3beta-ol
CHEMBL463973
CHEMBL560819
No. 111 No. 11
C00030353 External link 512 Ganoderic acid AP2
/ (+)-Ganoderic acid AP2
No. 268
C00034980 External link 512 (-)-7-Hydroxycalamenene
No. 824
C00036534 External link 512 3alpha-Carboxyacetoxyquercinic acid
/ 3alpha-Carboxyacetoxy-24-methyl-23-oxolanost-8-en-26-oic acid
CHEMBL448136
No. 1463
C00035046 External link 512 Applanoxidic acid E
No. 1849
C00035047 External link 512 Applanoxidic acid F
No. 1849
C00035049 External link 512 Applanoxidic acid H
No. 1849
C00035048 External link 512 Applanoxidic acid G
CHEMBL515052
No. 1849
C00030200 External link 512 Ergosterol peroxide
/ Ergosterol 5,8-peroxide
/ (-)-Ergosterol 5,8-peroxide
/ 5alpha,8alpha-Epidioxyergosta-6,22-dien-3beta-ol
/ (-)-5alpha,8alpha-Epidioxyergosta-6,22-dien-3beta-ol
CHEMBL434750
CHEMBL515808
CHEMBL1801968
CHEMBL1969254
C036071
1 / 0 / 0 1 / 4 No. 2300

Human Protein / Gene in interactions

16 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q96RI1 Bile acid receptor NR1H4 C00003747 C00030200 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003652 C00023765 0 / 1
P15121 Aldose reductase Enzyme C00030349 C00030351 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003652 1 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00023791 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00003652 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003652 0 / 1
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00003652 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00003652 2 / 3
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003652 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00003652 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003652 1 / 1
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor C00003747 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00003652 5 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00003652 4 / 3
P31939 Bifunctional purine biosynthesis protein PURH Enzyme C00003652 1 / 1

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00030200

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (14)

OMIM preferred title UniProt
#608688 Aicar transformylase/imp cyclohydrolase deficiency P31939
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#218800 Crigler-najjar syndrome, type i P22309
#606785 Crigler-najjar syndrome, type ii P22309
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#143500 Gilbert syndrome P22309
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (11)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00966 AICA-ribosiduria P31939 (related)
H01171 Poor drug metabolism (PM) P33261 (related)

Diseases related to CTD interactions

4 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001424 Bacterial Infections C00030200
D009369 Neoplasms C00030200
D011471 Prostatic Neoplasms C00030200
D014777 Virus Diseases C00030200