PCIDB

Rosa mutiflora

Species

KNApSAcK Entry

Organism name Rosa mutiflora
Genus Rosa
Family Rosaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Rosa
Linked NCBI taxonomy ID 3764
Linked level genus

Family

Family in NCBI taxonomy Rosaceae
ID 3745

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00005886 External link 512 Multiflorin A
C087918
No. 1 No. 15
C00005172 External link 512 Multifloein B
/ Multiflorin B
CHEMBL503913
No. 1 No. 15
C00005374 External link 512 Quercetin
CHEMBL82242
CHEMBL479232
CHEMBL1437696
C012526
14 / 2 / 2 2 / 1 No. 2 No. 15
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11

Human Protein / Gene in interactions

31 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003672 1 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003672 0 / 0
Q9P1W9 Serine/threonine-protein kinase pim-2 Pim C00005374 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 2 / 0
P06746 DNA polymerase beta Enzyme C00003672 0 / 0
P08047 Transcription factor Sp1 Unclassified protein C00003672 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00003672 3 / 2
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00005374 1 / 1
P08183 Multidrug resistance protein 1 drug C00003672 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003672 0 / 1
P07237 Protein disulfide-isomerase Enzyme C00005374 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00005374 0 / 0
P39748 Flap endonuclease 1 Enzyme C00005374 0 / 0
P15121 Aldose reductase Enzyme C00005374 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003672 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00005374 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00005374 0 / 0
P00734 Prothrombin S1A C00003672 4 / 2
P14679 Tyrosinase Oxidoreductase C00003672 4 / 2
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003672 0 / 0
P03372 Estrogen receptor NR3A1 C00003672 1 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003672 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003672 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00005374 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00005374 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00005374 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00005374 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00005374 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00003672 1 / 1
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00005374 0 / 0

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00005374
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00005374

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (21)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#218030 Apparent mineralocorticoid excess; ame P80365
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (14)

KEGG name UniProt
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00192 Xanthinuria P47989 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D010146 Pain C00005374