Species

KNApSAcK Entry

Organism name Boswellia papyrifera
Genus Boswellia
Family Burseraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Boswellia
Linked NCBI taxonomy ID 80276
Linked level genus

Family

Family in NCBI taxonomy Burseraceae
ID 4014

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00042045 External link 512 11-Keto-beta-boswellic acid
CHEMBL437964
CHEMBL236501
6 / 2 / 3 No. 13 No. 51
C00036795 External link 512 beta-Boswellic acid
CHEMBL267225
CHEMBL391836
C054625
7 / 0 / 1 2 / 0 No. 13 No. 51
C00042114 External link 512 3alpha-Acetoxy-27-hydroxylup-20(29)-en-24-oic acid
/ (+)-3alpha-Acetoxy-27-hydroxylup-20(29)-en-24-oic acid
CHEMBL499293
1 / 0 / 0 No. 23 No. 51
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00042279 External link 512 beta-Elemonic acid
CHEMBL498242
CHEMBL566929
3 / 0 / 0 No. 86 No. 51

Human Protein / Gene in interactions

27 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P48147 Prolyl endopeptidase S9A C00036795 C00042045 C00042114 C00042279 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003672 C00036795 C00042045 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 C00042045 1 / 1
P17706 Tyrosine-protein phosphatase non-receptor type 2 Tyr C00036795 C00042045 0 / 1
Q92830 Histone acetyltransferase KAT2A Enzyme C00036795 0 / 0
P06746 DNA polymerase beta Enzyme C00003672 0 / 0
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor C00042279 0 / 0
P08047 Transcription factor Sp1 Unclassified protein C00003672 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00003672 3 / 2
P08183 Multidrug resistance protein 1 drug C00003672 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003672 0 / 1
O14684 Prostaglandin E synthase Enzyme C00036795 0 / 0
P28845 Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme C00042045 1 / 1
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00042045 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003672 0 / 0
P00734 Prothrombin S1A C00003672 4 / 2
P14679 Tyrosinase Oxidoreductase C00003672 4 / 2
Q96RI1 Bile acid receptor NR1H4 C00042279 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003672 0 / 0
P03372 Estrogen receptor NR3A1 C00003672 1 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003672 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003672 0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00036795 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 2 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00036795 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003672 1 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00003672 1 / 1

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
7150 TOP1, TOPI topoisomerase (DNA) I (EC:5.99.1.2) C00036795
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00036795

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (20)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#218030 Apparent mineralocorticoid excess; ame P80365
#604931 Cortisone reductase deficiency 1; cortrd1 P28845
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#188050 Thrombophilia due to thrombin defect; thph1 P00734

KEGG DISEASE (14)

KEGG name UniProt
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00408 Type I diabetes mellitus P17706 (related)
H01111 Cortisone reductase deficiency (CRD) P28845 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)