Acnistus arborescens

• Index
• Plant Species
• Natural Activity
• Metabolite list (3)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Acnistus arborescens
Genus	Acnistus
Family	Solanaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Acnistus arborescens
Linked NCBI taxonomy ID	362341
Linked level	species

Family

Family in NCBI taxonomy	Solanaceae
ID	4070

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Natural Activity

List (8)

Species	Activity
Acnistus arborescens (L.) Schltdl.	Anticancer
Acnistus arborescens (L.) Schltdl.	Antileukemic
Acnistus arborescens (L.) Schltdl.	Antimalarial
Acnistus arborescens (L.) Schltdl.	Antiproliferant
Acnistus arborescens (L.) Schltdl.	Cytotoxic
Acnistus arborescens (L.) Schltdl.	Diuretic
Acnistus arborescens (L.) Schltdl.	Emollient
Acnistus arborescens (L.) Schltdl.	Piscicide

Metabolite list (3)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00003676	Withaferin A	CHEMBL517080 CHEMBL578716 CHEMBL1221986 CHEMBL1419012 CHEMBL2143369	C009684	27 / 22 / 15	7 / 2	No. 176	No. 58
C00044015	Withaphysalin M / (+)-Withaphysalin M	CHEMBL450392				No. 176	No. 58
C00044016	Withaphysalin N / (-)-Withaphysalin N	CHEMBL502237				No. 176	No. 58

Human Protein / Gene in interactions

27 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P17861	X-box-binding protein 1	Unclassified protein	C00003676	1 / 0
Q99700	Ataxin-2	Unclassified protein	C00003676	1 / 1
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00003676	2 / 0
P06746	DNA polymerase beta	Enzyme	C00003676	0 / 0
P42574	Caspase-3	C14	C00003676	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00003676	0 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00003676	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00003676	2 / 3
P42858	Huntingtin	Unclassified protein	C00003676	1 / 1
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00003676	2 / 0
O75496	Geminin	Unclassified protein	C00003676	0 / 0
P51151	Ras-related protein Rab-9A	Unclassified protein	C00003676	0 / 0
P32245	Melanocortin receptor 4	Melanocortin receptor	C00003676	1 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00003676	1 / 1
P07355	Annexin A2	Unclassified protein	C00003676	0 / 0
O15118	Niemann-Pick C1 protein	Unclassified protein	C00003676	1 / 1
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00003676	0 / 0
P31749	RAC-alpha serine/threonine-protein kinase	Akt	C00003676	4 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00003676	0 / 0
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00003676	1 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00003676	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00003676	4 / 3
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00003676	0 / 0
P11142	Heat shock cognate 71 kDa protein	Unclassified protein	C00003676	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00003676	1 / 0
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00003676	0 / 3
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00003676	2 / 1

7 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
468	ATF4, CREB-2, CREB2, TAXREB67, TXREB	activating transcription factor 4	C00003676
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00003676
1649	DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153	DNA-damage-inducible transcript 3	C00003676
54541	DDIT4, Dig2, REDD-1, REDD1	DNA-damage-inducible transcript 4	C00003676
83939	EIF2A, EIF-2A, MST089, MSTP004, MSTP089	eukaryotic translation initiation factor 2A, 65kDa	C00003676
5599	MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	C00003676
7494	XBP1, TREB5, XBP-1, XBP2	X-box binding protein 1	C00003676

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions