Bryonia alba
Species
KNApSAcK Entry
| Organism name | Bryonia alba |
|---|---|
| Genus | Bryonia |
| Family | Cucurbitaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Bryonia alba |
|---|---|
| Linked NCBI taxonomy ID | 243967 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Cucurbitaceae |
|---|---|
| ID | 3650 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Natural Activity
List (14)
| Species | Activity |
|---|---|
| Bryonia alba L. | Abortifacient |
| Bryonia alba L. | Antitumor |
| Bryonia alba L. | Cytotoxic |
| Bryonia alba L. | Diuretic |
| Bryonia alba L. | Emetic |
| Bryonia alba L. | Emmenagogue |
| Bryonia alba L. | Expectorant |
| Bryonia alba L. | Hydragogue |
| Bryonia alba L. | Hypoglycemic |
| Bryonia alba L. | Irritant |
| Bryonia alba L. | Lactagogue |
| Bryonia alba L. | Laxative |
| Bryonia alba L. | toxic |
| Bryonia alba L. | Vermifuge |
Metabolite list (7)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003683
|
Cucurbitacin B
|
CHEMBL367917
CHEMBL508185 CHEMBL507237 CHEMBL1708265 CHEMBL1728549 |
C041246
|
22 / 30 / 28 | No. 220 | No. 11 |
|
|
|
C00003684
|
Cucurbitacin C
|
CHEMBL449220
CHEMBL1355541 |
12 / 9 / 9 | No. 220 | No. 11 |
|
||
|
C00003686
|
Cucurbitacin E
|
CHEMBL455056
|
C102326
|
3 / 1 / 2 | No. 220 | No. 11 |
|
|
|
C00003689
|
Cucurbitacin I
|
CHEMBL387737
CHEMBL1317135 CHEMBL1717364 |
C038106
|
20 / 15 / 15 | 2 / 0 | No. 220 | No. 11 |
|
|
C00003690
|
Cucurbitacin J
|
CHEMBL1923789
CHEMBL1923790 CHEMBL1984707 |
No. 220 | No. 11 |
|
|||
|
C00031748
|
Dihydrocucurbitacin B
|
CHEMBL553851
|
1 / 1 / 2 | No. 220 | No. 11 |
|
||
|
C00031749
|
Dihydrocucurbitacin E
|
CHEMBL256519
|
No. 220 | No. 11 |
|
Human Protein / Gene in interactions
34 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q06710 | Paired box protein Pax-8 | Unclassified protein | C00003683 C00003684 C00003689 | 1 / 2 |
| O75496 | Geminin | Unclassified protein | C00003683 C00003684 C00003689 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00003683 C00003684 C00003689 | 1 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00003683 C00003684 C00003689 | 1 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00003683 C00003684 C00003689 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00003683 C00003684 C00003689 | 2 / 0 |
| P40763 | Signal transducer and activator of transcription 3 | Transcription Factor | C00003683 C00003686 C00031748 | 1 / 2 |
| P20701 | Integrin alpha-L | Membrane receptor | C00003683 C00003686 C00003689 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00003683 C00003684 C00003689 | 2 / 3 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00003683 C00003684 | 0 / 0 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00003683 C00003684 | 1 / 1 |
| P23528 | Cofilin-1 | Unclassified protein | C00003686 C00003689 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00003683 C00003684 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00003683 C00003689 | 4 / 1 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00003683 C00003689 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00003683 | 1 / 1 |
| P39748 | Flap endonuclease 1 | Enzyme | C00003683 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00003689 | 0 / 0 |
| P11308 | Transcriptional regulator ERG | Unclassified protein | C00003689 | 1 / 2 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00003684 | 1 / 2 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00003683 | 0 / 0 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00003683 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003689 | 0 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00003683 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003689 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003689 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003689 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00003684 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003683 | 4 / 3 |
| P02545 | Prelamin-A/C | Unclassified protein | C00003683 | 11 / 10 |
| P31939 | Bifunctional purine biosynthesis protein PURH | Enzyme | C00003689 | 1 / 1 |
| Q13315 | Serine-protein kinase ATM | Atypical serine/threonine protein kinase PIKK subfamily | C00003683 | 1 / 4 |
| P01215 | Glycoprotein hormones alpha chain | Unclassified protein | C00003689 | 0 / 3 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003689 | 1 / 0 |
2 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 3717 | JAK2, JTK10, THCYT3 | Janus kinase 2 (EC:2.7.10.2) |
C00003689
|
| 6774 | STAT3, APRF, HIES | signal transducer and activator of transcription 3 (acute-phase response factor) |
C00003689
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (35)
| OMIM | preferred title | UniProt |
|---|---|---|
| #608688 | Aicar transformylase/imp cyclohydrolase deficiency |
P31939
|
| #208900 | Ataxia-telangiectasia; at |
Q13315
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #612219 | Ewing sarcoma; es |
P11308
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #147060 | Hyper-ige recurrent infection syndrome, autosomal dominant |
P40763
|
| #218700 | Hypothyroidism, congenital, nongoitrous, 2; chng2 |
Q06710
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (38)
| KEGG | name | UniProt |
|---|---|---|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00081 | Hashimoto's thyroiditis |
P01215
(marker)
|
| H00082 | Graves' disease |
P01215
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P01215
(marker)
Q06710 (related) |
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00024 | Prostate cancer |
P11308
(related)
|
| H00035 | Ewing's sarcoma |
P11308
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00966 | AICA-ribosiduria |
P31939
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00016 | Oral cancer |
P40763
(related)
|
| H00107 | Other well-defined immunodeficiency syndromes |
P40763
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00032 | Thyroid cancer |
Q06710
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
Q13315
(related)
|
| H00064 | Ataxia telangiectasia (AT) |
Q13315
(related)
|
| H00094 | DNA repair defects |
Q13315
(related)
|
| H00848 | Ataxia with ocular apraxia (AOA) |
Q13315
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|