| Organism name | Casearia arborea | 
|---|---|
| Genus | Casearia | 
| Family | Samydaceae | 
| Kingdom | Plantae | 
| Linked NCBI taxonomy name | Casearia arborea | 
|---|---|
| Linked NCBI taxonomy ID | 681418 | 
| Linked level | species | 
| Family in NCBI taxonomy | Salicaceae | 
|---|---|
| ID | 3688 | 
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae | 
|---|---|
| ID | 33090 | 
| Plant class | rosids | 
|---|---|
| ID | 71275 | 
| KNApSAcK ID | name | ChEMBL link | CTD link | 
                        # of proteins in
                         ChEMBL interaction / related OMIM / related KEGG DISEASE  | 
                      
                        # of genes in
                         CTD interaction / related diseases  | 
                      
                        KCF-S
                         cluster  | 
                      
                        phytochemical
                         cluster  | 
                      figure | 
|---|---|---|---|---|---|---|---|---|
| 
                        C00003683
                        
                           | 
                      
                        Cucurbitacin B
                         | 
                      
                        CHEMBL367917
                         CHEMBL508185 CHEMBL507237 CHEMBL1708265 CHEMBL1728549  | 
                      
                        C041246
                         | 
                      22 / 30 / 28 | No. 220 | No. 11 | 
                         
                       | 
                    |
| 
                        C00047022
                        
                           | 
                      
                        Casearborin C
                         / (+)-Casearborin C  | 
                      
                        CHEMBL524707
                         | 
                      No. 895 | 
                         
                       | 
                    ||||
| 
                        C00047021
                        
                           | 
                      
                        Casearborin B
                         / (+)-Casearborin B  | 
                      
                        CHEMBL505172
                         | 
                      No. 895 | 
                         
                       | 
                    ||||
| 
                        C00047020
                        
                           | 
                      
                        Casearborin A
                         / (+)-Casearborin A  | 
                      
                        CHEMBL501177
                         | 
                      No. 895 | 
                         
                       | 
                    ||||
| 
                        C00047023
                        
                           | 
                      
                        Casearborin D
                         / (+)-Casearborin D  | 
                      
                        CHEMBL500119
                         | 
                      No. 895 | 
                         
                       | 
                    ||||
| 
                        C00047024
                        
                           | 
                      
                        Casearborin E
                         / (+)-Casearborin E  | 
                      
                        CHEMBL509263
                         CHEMBL1077477  | 
                      No. 895 | 
                         
                       | 
                    
| accession | description | class description | KNApSAcK metabolite in interactions | 
                          # of diseases
                           (OMIM / KEGG)  | 
                      
|---|---|---|---|---|
| Q16637 | Survival motor neuron protein | Unclassified protein | C00003683 | 4 / 1 | 
| Q99700 | Ataxin-2 | Unclassified protein | C00003683 | 1 / 1 | 
| Q13315 | Serine-protein kinase ATM | Atypical serine/threonine protein kinase PIKK subfamily | C00003683 | 1 / 4 | 
| P02545 | Prelamin-A/C | Unclassified protein | C00003683 | 11 / 10 | 
| P11387 | DNA topoisomerase 1 | Isomerase | C00003683 | 0 / 0 | 
| P11473 | Vitamin D3 receptor | NR1I1 | C00003683 | 2 / 3 | 
| P20701 | Integrin alpha-L | Membrane receptor | C00003683 | 0 / 0 | 
| P39748 | Flap endonuclease 1 | Enzyme | C00003683 | 0 / 0 | 
| P42858 | Huntingtin | Unclassified protein | C00003683 | 1 / 1 | 
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00003683 | 2 / 0 | 
| O75496 | Geminin | Unclassified protein | C00003683 | 0 / 0 | 
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00003683 | 0 / 0 | 
| P40763 | Signal transducer and activator of transcription 3 | Transcription Factor | C00003683 | 1 / 2 | 
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00003683 | 0 / 0 | 
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00003683 | 0 / 0 | 
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00003683 | 0 / 0 | 
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00003683 | 1 / 1 | 
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00003683 | 0 / 0 | 
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003683 | 4 / 3 | 
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00003683 | 0 / 0 | 
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00003683 | 1 / 0 | 
| Q06710 | Paired box protein Pax-8 | Unclassified protein | C00003683 | 1 / 2 | 
| OMIM | preferred title | UniProt | 
|---|---|---|
| #208900 | Ataxia-telangiectasia; at | 
                            Q13315
                             | 
                        
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a | 
                            P02545
                             | 
                        
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism | 
                            P02545
                             | 
                        
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 | 
                            P02545
                             | 
                        
| #114500 | Colorectal cancer; crc | 
                            P84022
                             | 
                        
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 | 
                            P02545
                             | 
                        
| #600274 | Frontotemporal dementia; ftd | 
                            P10636
                             | 
                        
| #137800 | Glioma susceptibility 1; glm1 | 
                            O75874
                             | 
                        
| #610140 | Heart-hand syndrome, slovenian type | 
                            P02545
                             | 
                        
| #143100 | Huntington disease; hd | 
                            P42858
                             | 
                        
| #176670 | Hutchinson-gilford progeria syndrome; hgps | 
                            P02545
                             | 
                        
| #147060 | Hyper-ige recurrent infection syndrome, autosomal dominant | 
                            P40763
                             | 
                        
| #218700 | Hypothyroidism, congenital, nongoitrous, 2; chng2 | 
                            Q06710
                             | 
                        
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 | 
                            P02545
                             | 
                        
| #613795 | Loeys-dietz syndrome, type 3; lds3 | 
                            P84022
                             | 
                        
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada | 
                            P02545
                             | 
                        
| #613205 | Muscular dystrophy, congenital, lmna-related | 
                            P02545
                             | 
                        
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b | 
                            P02545
                             | 
                        
| #607948 | Mycobacterium tuberculosis, susceptibility to | 
                            P11473
                             | 
                        
| #257220 | Niemann-pick disease, type c1; npc1 | 
                            O15118
                             | 
                        
| #260540 | Parkinson-dementia syndrome | 
                            P10636
                             | 
                        
| #172700 | Pick disease of brain | 
                            P10636
                             | 
                        
| #275210 | Restrictive dermopathy, lethal | 
                            P02545
                             | 
                        
| #253300 | Spinal muscular atrophy, type i; sma1 | 
                            Q16637
                             | 
                        
| #253550 | Spinal muscular atrophy, type ii; sma2 | 
                            Q16637
                             | 
                        
| #253400 | Spinal muscular atrophy, type iii; sma3 | 
                            Q16637
                             | 
                        
| #271150 | Spinal muscular atrophy, type iv; sma4 | 
                            Q16637
                             | 
                        
| #183090 | Spinocerebellar ataxia 2; sca2 | 
                            Q99700
                             | 
                        
| #601104 | Supranuclear palsy, progressive, 1; psnp1 | 
                            P10636
                             | 
                        
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a | 
                            P11473
                             | 
                        
| KEGG | name | UniProt | 
|---|---|---|
| H00136 | Niemann-Pick disease type C (NPC) | 
                            O15118
                            (related)
                             | 
                        
| H00264 | Charcot-Marie-Tooth disease (CMT) | 
                            P02545
                            (related)
                             | 
                        
| H00294 | Dilated cardiomyopathy (DCM) | 
                            P02545
                            (related)
                             | 
                        
| H00420 | Familial partial lipodystrophy (FPL) | 
                            P02545
                            (related)
                             | 
                        
| H00563 | Emery-Dreifuss muscular dystrophy | 
                            P02545
                            (related)
                             | 
                        
| H00590 | Congenital muscular dystrophies (CMD/MDC) | 
                            P02545
                            (related)
                             | 
                        
| H00593 | Limb-girdle muscular dystrophy (LGMD) | 
                            P02545
                            (related)
                             | 
                        
| H00601 | Hutchinson-Gilford progeria syndrome | 
                            P02545
                            (related)
                             | 
                        
| H00663 | Restrictive dermopathy | 
                            P02545
                            (related)
                             | 
                        
| H00665 | Mandibuloacral dysplasia | 
                            P02545
                            (related)
                             | 
                        
| H01216 | Left ventricular noncompaction (LVNC) | 
                            P02545
                            (related)
                             | 
                        
| H00058 | Amyotrophic lateral sclerosis (ALS) | 
                            P10636
                            (related)
                             | 
                        
| H00077 | Progressive supranuclear palsy (PSP) | 
                            P10636
                            (related)
                             | 
                        
| H00078 | Frontotemporal lobar degeneration (FTLD) | 
                            P10636
                            (related)
                             | 
                        
| H00342 | Tuberculosis | 
                            P11473
                            (related)
                             | 
                        
| H00784 | Localized autosomal recessive hypotrichosis | 
                            P11473
                            (related)
                             | 
                        
| H01143 | Vitamin D-dependent rickets | 
                            P11473
                            (related)
                             | 
                        
| H00016 | Oral cancer | 
                            P40763
                            (related)
                             | 
                        
| H00107 | Other well-defined immunodeficiency syndromes | 
                            P40763
                            (related)
                             | 
                        
| H00059 | Huntington's disease (HD) | 
                            P42858
                            (related)
                             | 
                        
| H00032 | Thyroid cancer | 
                            Q06710
                            (related)
                             | 
                        
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) | 
                            Q06710
                            (related)
                             | 
                        
| H00005 | Chronic lymphocytic leukemia (CLL) | 
                            Q13315
                            (related)
                             | 
                        
| H00064 | Ataxia telangiectasia (AT) | 
                            Q13315
                            (related)
                             | 
                        
| H00094 | DNA repair defects | 
                            Q13315
                            (related)
                             | 
                        
| H00848 | Ataxia with ocular apraxia (AOA) | 
                            Q13315
                            (related)
                             | 
                        
| H00455 | Spinal muscular atrophy (SMA) | 
                            Q16637
                            (related)
                             | 
                        
| H00063 | Spinocerebellar ataxia (SCA) | 
                            Q99700
                            (related)
                             |