Species

KNApSAcK Entry

Organism name Iberis spp.
Genus Iberis
Family Cruciferae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Iberis
Linked NCBI taxonomy ID 190883
Linked level genus

Family

Family in NCBI taxonomy Brassicaceae
ID 3700

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00003683 External link 512 Cucurbitacin B
CHEMBL367917
CHEMBL508185
CHEMBL507237
CHEMBL1708265
CHEMBL1728549
C041246
22 / 30 / 28 No. 220 No. 11
C00003685 External link 512 Cucurbitacin D
CHEMBL493646
CHEMBL492404
C038105
1 / 0 / 0 No. 220 No. 11

Human Protein / Gene in interactions

22 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P20701 Integrin alpha-L Membrane receptor C00003683 C00003685 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00003683 0 / 0
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily C00003683 1 / 4
P02545 Prelamin-A/C Unclassified protein C00003683 11 / 10
P11387 DNA topoisomerase 1 Isomerase C00003683 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00003683 2 / 3
Q16637 Survival motor neuron protein Unclassified protein C00003683 4 / 1
P39748 Flap endonuclease 1 Enzyme C00003683 0 / 0
P42858 Huntingtin Unclassified protein C00003683 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00003683 2 / 0
O75496 Geminin Unclassified protein C00003683 0 / 0
Q99700 Ataxin-2 Unclassified protein C00003683 1 / 1
P40763 Signal transducer and activator of transcription 3 Transcription Factor C00003683 1 / 2
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00003683 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00003683 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00003683 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00003683 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00003683 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00003683 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00003683 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00003683 1 / 0
Q06710 Paired box protein Pax-8 Unclassified protein C00003683 1 / 2

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (30)

OMIM preferred title UniProt
#208900 Ataxia-telangiectasia; at Q13315
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#610140 Heart-hand syndrome, slovenian type P02545
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#147060 Hyper-ige recurrent infection syndrome, autosomal dominant P40763
#218700 Hypothyroidism, congenital, nongoitrous, 2; chng2 Q06710
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#257220 Niemann-pick disease, type c1; npc1 O15118
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (28)

KEGG name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00016 Oral cancer P40763 (related)
H00107 Other well-defined immunodeficiency syndromes P40763 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00032 Thyroid cancer Q06710 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) Q06710 (related)
H00005 Chronic lymphocytic leukemia (CLL) Q13315 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00094 DNA repair defects Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)