Gratiola officinalis

• Index
• Plant Species
• Natural Activity
• Metabolite list (7)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Gratiola officinalis
Genus	Gratiola
Family	Plantaginaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Gratiola officinalis
Linked NCBI taxonomy ID	204382
Linked level	species

Family

Family in NCBI taxonomy	Plantaginaceae
ID	156152

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Natural Activity

List (10)

Species	Activity
Gratiola officinalis L.	Cardiotonic
Gratiola officinalis L.	Cytotoxic
Gratiola officinalis L.	Digitalic
Gratiola officinalis L.	Diuretic
Gratiola officinalis L.	Emetic
Gratiola officinalis L.	Laxative
Gratiola officinalis L.	Parasiticide
Gratiola officinalis L.	toxic
Gratiola officinalis L.	Vermifuge
Gratiola officinalis L.	Vulnerary

Metabolite list (7)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00013642	8-Hydroxyapigenin 8-sophoroside / 8-[(2-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one					No. 1	No. 15
C00004497	8-Hydroxyapigenin 7-sophoroside					No. 1	No. 15
C00004518	Hypolaetin 7-sophoroside / 8-Hydroxyluteolin 7-sophoroside / 7-[(2-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)oxy]-2-(3,4-dihydroxyphenyl)-5,8-dihydroxy-4H-1-benzopyran-4-one					No. 1	No. 15
C00004521	8-Hydroxyluteolin 4'-methyl ether 7-(6'''-acetylallosyl)(1->2)(6''-acetylglucoside)					No. 1	No. 15
C00004520	8-Hydroxyluteolin 3'-methyl ether 7-sophoroside					No. 1	No. 15
C00004519	8-Hydroxychrysoeriol 8-glucuronide / 8-Hydroxyluteolin 3'-methyl ether 8-glucuronide / 5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-oxo-4H-1-benzopyran-8-yl beta-D-glucopyranosiduronic acid					No. 2	No. 15
C00003689	Cucurbitacin I	CHEMBL387737 CHEMBL1317135 CHEMBL1717364	C038106	20 / 15 / 15	2 / 0	No. 220	No. 11

Human Protein / Gene in interactions

20 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00003689	1 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00003689	4 / 1
Q99700	Ataxin-2	Unclassified protein	C00003689	1 / 1
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00003689	0 / 1
P11473	Vitamin D3 receptor	NR1I1	C00003689	2 / 3
P20701	Integrin alpha-L	Membrane receptor	C00003689	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00003689	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00003689	2 / 0
O75496	Geminin	Unclassified protein	C00003689	0 / 0
P23528	Cofilin-1	Unclassified protein	C00003689	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00003689	0 / 0
P11308	Transcriptional regulator ERG	Unclassified protein	C00003689	1 / 2
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00003689	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00003689	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00003689	0 / 1
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00003689	0 / 0
P31939	Bifunctional purine biosynthesis protein PURH	Enzyme	C00003689	1 / 1
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00003689	1 / 0
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00003689	0 / 3
Q06710	Paired box protein Pax-8	Unclassified protein	C00003689	1 / 2

2 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
3717	JAK2, JTK10, THCYT3	Janus kinase 2 (EC:2.7.10.2)	C00003689
6774	STAT3, APRF, HIES	signal transducer and activator of transcription 3 (acute-phase response factor)	C00003689

Related Diseases

Diseases related to proteins in ChEMBL interactions