| Organism name | Brucea japonica | 
|---|---|
| Genus | Brucea | 
| Family | Simaroubaceae | 
| Kingdom | Plantae | 
| Linked NCBI taxonomy name | Brucea | 
|---|---|
| Linked NCBI taxonomy ID | 43722 | 
| Linked level | genus | 
| Family in NCBI taxonomy | Simaroubaceae | 
|---|---|
| ID | 23808 | 
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae | 
|---|---|
| ID | 33090 | 
| Plant class | rosids | 
|---|---|
| ID | 71275 | 
| KNApSAcK ID | name | ChEMBL link | CTD link | # of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE | # of genes in CTD interaction / related diseases | KCF-S cluster | phytochemical cluster | figure | 
|---|---|---|---|---|---|---|---|---|
| C00032537   | Yadanziolide S / (+)-Yadanziolide S | No. 432 | No. 51 |   | ||||
| C00029858   | Bruceoside B / (+)-Bruceoside B | CHEMBL2029084 | C068162 | No. 875 | No. 51 |   | ||
| C00003704   | Brusatol | CHEMBL450464 CHEMBL1702665 | C020237 | 9 / 15 / 8 | 2 / 0 | No. 2130 | No. 51 |   | 
| accession | description | class description | KNApSAcK metabolite in interactions | # of diseases (OMIM / KEGG) | 
|---|---|---|---|---|
| Q99700 | Ataxin-2 | Unclassified protein | C00003704 | 1 / 1 | 
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003704 | 2 / 0 | 
| P37840 | Alpha-synuclein | Unclassified protein | C00003704 | 4 / 2 | 
| O75496 | Geminin | Unclassified protein | C00003704 | 0 / 0 | 
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00003704 | 7 / 3 | 
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00003704 | 0 / 0 | 
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00003704 | 0 / 0 | 
| P05412 | Transcription factor AP-1 | Transcription Factor | C00003704 | 0 / 0 | 
| Q06710 | Paired box protein Pax-8 | Unclassified protein | C00003704 | 1 / 2 | 
| gene | gene name | gene description | KNApSAcK metabolite in interactions | 
|---|---|---|---|
| 9817 | KEAP1, INrf2, KLHL19 | kelch-like ECH-associated protein 1 | C00003704 | 
| 4780 | NFE2L2, NRF2 | nuclear factor, erythroid 2-like 2 | C00003704 | 
| OMIM | preferred title | UniProt | 
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah | P63092 | 
| #127750 | Dementia, lewy body; dlb | P37840 | 
| #218700 | Hypothyroidism, congenital, nongoitrous, 2; chng2 | Q06710 | 
| #174800 | Mccune-albright syndrome; mas | P63092 | 
| #166350 | Osseous heteroplasia, progressive; poh | P63092 | 
| #168601 | Parkinson disease 1, autosomal dominant; park1 | P37840 | 
| #605543 | Parkinson disease 4, autosomal dominant; park4 | P37840 | 
| #168600 | Parkinson disease, late-onset; pd | P37840 | 
| #102200 | Pituitary adenoma, growth hormone-secreting | P63092 | 
| #103580 | Pseudohypoparathyroidism, type ia; php1a | P63092 | 
| #603233 | Pseudohypoparathyroidism, type ib; php1b | P63092 | 
| #612462 | Pseudohypoparathyroidism, type ic; php1c | P63092 | 
| #604906 | Schizophrenia 9; sczd9 | P49798 | 
| #181500 | Schizophrenia; sczd | P49798 | 
| #183090 | Spinocerebellar ataxia 2; sca2 | Q99700 | 
| KEGG | name | UniProt | 
|---|---|---|
| H00057 | Parkinson's disease (PD) | P37840
                            (related) | 
| H00066 | Lewy body dementia (LBD) | P37840
                            (related) | 
| H00244 | Pseudohypoparathyroidism | P63092
                            (related) | 
| H00441 | Progressive osseous heteroplasia (POH) | P63092
                            (related) | 
| H00501 | Fibrous dysplasia, polyostotic | P63092
                            (related) | 
| H00032 | Thyroid cancer | Q06710
                            (related) | 
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) | Q06710
                            (related) | 
| H00063 | Spinocerebellar ataxia (SCA) | Q99700
                            (related) |