Centella asiatica
Species
KNApSAcK Entry
| Organism name | Centella asiatica |
|---|---|
| Genus | Centella |
| Family | Araliaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Centella asiatica |
|---|---|
| Linked NCBI taxonomy ID | 48106 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Apiaceae |
|---|---|
| ID | 4037 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Natural Activity
List (65)
| Species | Activity |
|---|---|
| Centella asiatica (L.) Urb. | Adaptogen |
| Centella asiatica (L.) Urb. | Alterative |
| Centella asiatica (L.) Urb. | Analgesic |
| Centella asiatica (L.) Urb. | Angiogenic |
| Centella asiatica (L.) Urb. | Antiallergic |
| Centella asiatica (L.) Urb. | Antibacterial |
| Centella asiatica (L.) Urb. | Anticonvulsant |
| Centella asiatica (L.) Urb. | Antidepressant |
| Centella asiatica (L.) Urb. | Antidote |
| Centella asiatica (L.) Urb. | Antiedemic |
| Centella asiatica (L.) Urb. | Antifertility |
| Centella asiatica (L.) Urb. | Antiinflammatory |
| Centella asiatica (L.) Urb. | Antileprotic |
| Centella asiatica (L.) Urb. | Antimitotic |
| Centella asiatica (L.) Urb. | Antipyretic |
| Centella asiatica (L.) Urb. | Antirheumatic |
| Centella asiatica (L.) Urb. | Antiseptic |
| Centella asiatica (L.) Urb. | Antispasmodic |
| Centella asiatica (L.) Urb. | Antistress |
| Centella asiatica (L.) Urb. | Antitumor |
| Centella asiatica (L.) Urb. | Antiulcer |
| Centella asiatica (L.) Urb. | Antiuronic-acid |
| Centella asiatica (L.) Urb. | Antiviral |
| Centella asiatica (L.) Urb. | Anxiolytic |
| Centella asiatica (L.) Urb. | Aphrodisiac |
| Centella asiatica (L.) Urb. | Arylsulfatase Inhibitor |
| Centella asiatica (L.) Urb. | Beta-Glucuronidase Inhibitor |
| Centella asiatica (L.) Urb. | Bitter |
| Centella asiatica (L.) Urb. | Carcinogenic |
| Centella asiatica (L.) Urb. | Cerebrotonic |
| Centella asiatica (L.) Urb. | Cholinergic |
| Centella asiatica (L.) Urb. | Cicatrizant |
| Centella asiatica (L.) Urb. | Circulostimulant |
| Centella asiatica (L.) Urb. | CNS Depressant |
| Centella asiatica (L.) Urb. | Collagenic |
| Centella asiatica (L.) Urb. | Cytotoxic |
| Centella asiatica (L.) Urb. | Depurative |
| Centella asiatica (L.) Urb. | Dermagenic |
| Centella asiatica (L.) Urb. | Detoxicant |
| Centella asiatica (L.) Urb. | Digestive |
| Centella asiatica (L.) Urb. | Diuretic |
| Centella asiatica (L.) Urb. | Emmenagogue |
| Centella asiatica (L.) Urb. | Fungicide |
| Centella asiatica (L.) Urb. | GABA-Antagonist |
| Centella asiatica (L.) Urb. | GABA-nergic |
| Centella asiatica (L.) Urb. | Hypoglycemic |
| Centella asiatica (L.) Urb. | Immunomodulator |
| Centella asiatica (L.) Urb. | Immunostimulant |
| Centella asiatica (L.) Urb. | Lactagogue |
| Centella asiatica (L.) Urb. | Laxative |
| Centella asiatica (L.) Urb. | Memorigenic |
| Centella asiatica (L.) Urb. | Mucogenic |
| Centella asiatica (L.) Urb. | Narcotic |
| Centella asiatica (L.) Urb. | Nervine |
| Centella asiatica (L.) Urb. | Phagocytotic |
| Centella asiatica (L.) Urb. | Propecic |
| Centella asiatica (L.) Urb. | Radioprotective |
| Centella asiatica (L.) Urb. | Restorative |
| Centella asiatica (L.) Urb. | Sedative |
| Centella asiatica (L.) Urb. | Spermicide |
| Centella asiatica (L.) Urb. | Stimulant |
| Centella asiatica (L.) Urb. | Stomachic |
| Centella asiatica (L.) Urb. | Tonic |
| Centella asiatica (L.) Urb. | Tranquilizer |
| Centella asiatica (L.) Urb. | Vulnerary |
Metabolite list (1)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003739
|
Asiatic acid
|
CHEMBL278622
CHEMBL404313 CHEMBL1395292 CHEMBL1488520 CHEMBL1564373 CHEMBL1773214 |
C017032
|
11 / 14 / 43 | 1 / 0 | No. 13 | No. 51 |
|
Human Protein / Gene in interactions
11 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003739 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00003739 | 7 / 37 |
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00003739 | 0 / 0 |
| Q8TDU6 | G-protein coupled bile acid receptor 1 | Steroid-like ligand receptor | C00003739 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00003739 | 3 / 2 |
| P15121 | Aldose reductase | Enzyme | C00003739 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00003739 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003739 | 0 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00003739 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003739 | 4 / 3 |
| P17706 | Tyrosine-protein phosphatase non-receptor type 2 | Tyr | C00003739 | 0 / 1 |
1 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 7416 | VDAC1, PORIN, VDAC-1 | voltage-dependent anion channel 1 |
C00003739
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (14)
| OMIM | preferred title | UniProt |
|---|---|---|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #133239 | Esophageal cancer |
P04637
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #211980 | Lung cancer |
P04637
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
KEGG DISEASE (43)
| KEGG | name | UniProt |
|---|---|---|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00408 | Type I diabetes mellitus |
P17706
(related)
|