PCIDB

Asteracantha longifolia

Species

KNApSAcK Entry

Organism name Asteracantha longifolia
Genus
Family
Kingdom

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00003740 External link 512 Betulin
CHEMBL23236
CHEMBL140040
CHEMBL1610940
CHEMBL2000891
CHEMBL2069124
C002503
18 / 16 / 17 0 / 2 No. 23 No. 51
C00003749 External link 512 Lupeol
/ Lupenol
/ (+)-Lupenol
CHEMBL289191
CHEMBL459702
C010480
3 / 0 / 0 2 / 6 No. 23 No. 51
C00023774 External link 512 Fucostanol
/ Stigmasterol
/ Dihydro-beta-sitosterol
/ (24S)24-Ethylcholestain-3beta-ol
CHEMBL66943
CHEMBL186373
CHEMBL400247
CHEMBL1568947
D013265
5 / 0 / 0 1 / 0 No. 53 No. 11

Human Protein / Gene in interactions

23 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P11388 DNA topoisomerase 2-alpha Isomerase C00003740 C00003749 C00023774 0 / 0
P11387 DNA topoisomerase 1 Isomerase C00003740 C00003749 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003740 0 / 1
P06746 DNA polymerase beta Enzyme C00023774 0 / 0
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor C00003740 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00003740 0 / 0
P02545 Prelamin-A/C Unclassified protein C00003740 11 / 10
P08047 Transcription factor Sp1 Unclassified protein C00003749 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00003740 3 / 1
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00023774 0 / 0
Q02156 Protein kinase C epsilon type Eta C00003740 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00003740 0 / 3
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003740 1 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003740 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00003740 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00003740 0 / 0
Q96RI1 Bile acid receptor NR1H4 C00003740 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003740 0 / 0
P09884 DNA polymerase alpha catalytic subunit Transferase C00023774 0 / 0
P05771 Protein kinase C beta type Alpha C00003740 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003740 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003740 0 / 1
Q02880 DNA topoisomerase 2-beta Isomerase C00023774 0 / 0

3 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1499 CTNNB1, CTNNB, MRD19, armadillo catenin (cadherin-associated protein), beta 1, 88kDa C00003749
5728 PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) C00003749
10599 SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 solute carrier organic anion transporter family, member 1B1 C00023774

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (16)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#275210 Restrictive dermopathy, lethal P02545
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (17)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)

Diseases related to CTD interactions

8 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003110 Colonic Neoplasms C00003740
D064420 Drug-Related Side Effects and Adverse Reactions C00003740
D006528 Carcinoma, Hepatocellular C00003749
D009202 Cardiomyopathies C00003749
D006937 Hypercholesterolemia C00003749
D009374 Neoplasms, Experimental C00003749
D012878 Skin Neoplasms C00003749
D014947 Wounds and Injuries C00003749