Coussarea paniculata
Species
KNApSAcK Entry
| Organism name | Coussarea paniculata |
|---|---|
| Genus | Coussarea |
| Family | Rubiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Coussarea |
|---|---|
| Linked NCBI taxonomy ID | 60043 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Rubiaceae |
|---|---|
| ID | 24966 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (6)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00019064
|
Oleanolic acid
/ Astrantiagenin C / Virgaureagenin B / 3beta-Hydroxyolean-12-en-28-oic acid |
CHEMBL56615
CHEMBL168 CHEMBL180553 CHEMBL365375 CHEMBL486382 CHEMBL1413646 CHEMBL1436454 |
D009828
|
30 / 8 / 12 | 21 / 15 | No. 13 | No. 51 |
|
|
C00003740
|
Betulin
|
CHEMBL23236
CHEMBL140040 CHEMBL1610940 CHEMBL2000891 CHEMBL2069124 |
C002503
|
18 / 16 / 17 | 0 / 2 | No. 23 | No. 51 |
|
|
C00003749
|
Lupeol
/ Lupenol / (+)-Lupenol |
CHEMBL289191
CHEMBL459702 |
C010480
|
3 / 0 / 0 | 2 / 6 | No. 23 | No. 51 |
|
|
C00003741
|
Betulinic acid
|
CHEMBL269277
CHEMBL71690 CHEMBL519059 CHEMBL1318530 CHEMBL2005635 |
C002070
|
34 / 17 / 14 | 10 / 2 | No. 23 | No. 51 |
|
|
C00034390
|
3-epi-Betulinic acid
|
CHEMBL269277
CHEMBL71690 CHEMBL519059 CHEMBL1318530 CHEMBL2005635 |
34 / 17 / 14 | No. 23 | No. 51 |
|
||
|
C00029633
|
Ursolic acid
/ Acetylursolic acid |
CHEMBL55086
CHEMBL410525 |
4 / 2 / 2 | No. 177 |
|
Human Protein / Gene in interactions
60 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P11387 | DNA topoisomerase 1 | Isomerase | C00003740 C00003741 C00003749 C00034390 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00003740 C00003741 C00019064 C00034390 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00003740 C00003741 C00003749 C00034390 | 0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00003740 C00003741 C00019064 C00034390 | 0 / 0 |
| Q8TDU6 | G-protein coupled bile acid receptor 1 | Steroid-like ligand receptor | C00003740 C00003741 C00019064 C00034390 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00003741 C00019064 C00029633 C00034390 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003740 C00003741 C00034390 | 1 / 0 |
| P05771 | Protein kinase C beta type | Alpha | C00003740 C00003741 C00034390 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003740 C00003741 C00034390 | 0 / 0 |
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00003741 C00019064 C00034390 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00003740 C00003741 C00034390 | 11 / 10 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003741 C00019064 C00034390 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00003741 C00019064 C00034390 | 0 / 0 |
| Q02156 | Protein kinase C epsilon type | Eta | C00003740 C00003741 C00034390 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00003741 C00019064 C00034390 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003740 C00003741 C00034390 | 0 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003740 C00003741 C00034390 | 0 / 1 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00003740 C00003741 C00034390 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003740 C00003741 C00034390 | 1 / 1 |
| Q8IUX4 | DNA dC->dU-editing enzyme APOBEC-3F | Enzyme | C00003741 C00034390 | 0 / 0 |
| Q9UBT2 | SUMO-activating enzyme subunit 2 | Enzyme | C00003741 C00034390 | 0 / 0 |
| P15559 | NAD(P)H dehydrogenase [quinone] 1 | Enzyme | C00003741 C00034390 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003741 C00034390 | 2 / 0 |
| P08151 | Zinc finger protein GLI1 | Unclassified protein | C00003741 C00034390 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00019064 C00029633 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00003741 C00034390 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00003741 C00034390 | 1 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00003741 C00034390 | 0 / 0 |
| Q04206 | Transcription factor p65 | Transcription Factor | C00003741 C00034390 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00003741 C00034390 | 1 / 1 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00003740 C00019064 | 0 / 3 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00003741 C00034390 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00003741 C00034390 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00019064 C00029633 | 2 / 2 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003740 C00019064 | 0 / 0 |
| Q13133 | Oxysterols receptor LXR-alpha | NR1H3 | C00003741 C00034390 | 0 / 0 |
| P55055 | Oxysterols receptor LXR-beta | NR1H3 | C00003741 C00034390 | 0 / 0 |
| Q9UBE0 | SUMO-activating enzyme subunit 1 | Unclassified protein | C00003741 C00034390 | 0 / 0 |
| P35236 | Tyrosine-protein phosphatase non-receptor type 7 | Tyr | C00019064 | 0 / 0 |
| P18433 | Receptor-type tyrosine-protein phosphatase alpha | Receptor tyrosine-protein phosphatase | C00019064 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00019064 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00003740 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00019064 | 0 / 0 |
| P35228 | Nitric oxide synthase, inducible | Enzyme | C00019064 | 1 / 1 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00019064 | 0 / 0 |
| P10586 | Receptor-type tyrosine-protein phosphatase F | Receptor tyrosine-protein phosphatase | C00019064 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00019064 | 0 / 0 |
| P51452 | Dual specificity protein phosphatase 3 | Ser_Thr_Tyr | C00019064 | 0 / 0 |
| P17706 | Tyrosine-protein phosphatase non-receptor type 2 | Tyr | C00019064 | 0 / 1 |
| P29350 | Tyrosine-protein phosphatase non-receptor type 6 | Tyr | C00019064 | 0 / 0 |
| P04054 | Phospholipase A2 | Enzyme | C00019064 | 0 / 0 |
| P23469 | Receptor-type tyrosine-protein phosphatase epsilon | Receptor tyrosine-protein phosphatase | C00019064 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00003740 | 3 / 1 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00029633 | 0 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003749 | 0 / 0 |
| P24666 | Low molecular weight phosphotyrosine protein phosphatase | Tyr | C00019064 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00019064 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00019064 | 1 / 4 |
| Q06124 | Tyrosine-protein phosphatase non-receptor type 11 | Tyr | C00019064 | 4 / 2 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00019064 | 0 / 0 |
27 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00003741
C00019064
|
| 5728 | PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 | phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) |
C00003749
C00019064
|
| 7153 | TOP2A, TOP2, TP2A | topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) |
C00003741
C00019064
|
| 7150 | TOP1, TOPI | topoisomerase (DNA) I (EC:5.99.1.2) |
C00003741
C00019064
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00003741
C00019064
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00003741
C00019064
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00019064
|
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) |
C00003741
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00003741
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00003741
|
| 1499 | CTNNB1, CTNNB, MRD19, armadillo | catenin (cadherin-associated protein), beta 1, 88kDa |
C00003749
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00003741
|
| 177 | AGER, RAGE | advanced glycosylation end product-specific receptor |
C00019064
|
| 1956 | EGFR, ERBB, ERBB1, HER1, PIG61, mENA | epidermal growth factor receptor (EC:2.7.10.1) |
C00003741
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00019064
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00019064
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00019064
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00019064
|
| 3065 | HDAC1, GON-10, HD1, RPD3, RPD3L1 | histone deacetylase 1 (EC:3.5.1.98) |
C00019064
|
| 3146 | HMGB1, HMG1, HMG3, SBP-1 | high mobility group box 1 |
C00019064
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00019064
|
| 4233 | MET, AUTS9, HGFR, RCCP2, c-Met | met proto-oncogene (EC:2.7.10.1) |
C00019064
|
| 4780 | NFE2L2, NRF2 | nuclear factor, erythroid 2-like 2 |
C00019064
|
| 5052 | PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2 | peroxiredoxin 1 (EC:1.11.1.15) |
C00019064
|
| 6401 | SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 | selectin E |
C00019064
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00019064
|
| 7412 | VCAM1, CD106, INCAM-100 | vascular cell adhesion molecule 1 |
C00019064
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (28)
| OMIM | preferred title | UniProt |
|---|---|---|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
Q06124
|
| #151100 | Leopard syndrome 1 |
Q06124
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #611162 | Malaria, susceptibility to |
P35228
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #156250 | Metachondromatosis; metcds |
Q06124
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #163950 | Noonan syndrome 1; ns1 |
Q06124
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (27)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00408 | Type I diabetes mellitus |
P17706
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00017 | Esophageal cancer |
P35228
(related)
P35354 (related) |
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00523 | Noonan syndrome and related disorders |
Q06124
(related)
|
| H01018 | Metachondromatosis |
Q06124
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
24 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D008103 | Liver Cirrhosis |
C00003741
C00019064 |
| D050171 | Dyslipidemias |
C00019064
|
| D003110 | Colonic Neoplasms |
C00003740
|
| D064420 | Drug-Related Side Effects and Adverse Reactions |
C00003740
|
| D006528 | Carcinoma, Hepatocellular |
C00003749
|
| D009202 | Cardiomyopathies |
C00003749
|
| D006937 | Hypercholesterolemia |
C00003749
|
| D009374 | Neoplasms, Experimental |
C00003749
|
| D012878 | Skin Neoplasms |
C00003749
|
| D014947 | Wounds and Injuries |
C00003749
|
| D002252 | Carbon Tetrachloride Poisoning |
C00019064
|
| D056486 | Drug-Induced Liver Injury |
C00019064
|
| D008545 | Melanoma |
C00003741
|
| D018149 | Glucose Intolerance |
C00019064
|
| D006949 | Hyperlipidemias |
C00019064
|
| D007249 | Inflammation |
C00019064
|
| D007674 | Kidney Diseases |
C00019064
|
| D008106 | Liver Cirrhosis, Experimental |
C00019064
|
| D008107 | Liver Diseases |
C00019064
|
| D017202 | Myocardial Ischemia |
C00019064
|
| D009369 | Neoplasms |
C00019064
|
| D009765 | Obesity |
C00019064
|
| D011041 | Poisoning |
C00019064
|
| D011230 | Precancerous Conditions |
C00019064
|