PCIDB

Maytenus cuzcoina

Species

KNApSAcK Entry

Organism name Maytenus cuzcoina
Genus Maytenus
Family Celastraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Maytenus
Linked NCBI taxonomy ID 123430
Linked level genus

Family

Family in NCBI taxonomy Celastraceae
ID 4305

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (13)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00003740 External link 512 Betulin
CHEMBL23236
CHEMBL140040
CHEMBL1610940
CHEMBL2000891
CHEMBL2069124
C002503
18 / 16 / 17 0 / 2 No. 23 No. 51
C00003749 External link 512 Lupeol
/ Lupenol
/ (+)-Lupenol
CHEMBL289191
CHEMBL459702
C010480
3 / 0 / 0 2 / 6 No. 23 No. 51
C00019220 External link 512 Lupenone
CHEMBL486393
CHEMBL575188
3 / 4 / 2 No. 23 No. 51
C00023788 External link 512 Glochidone
CHEMBL469628
No. 23 No. 51
C00023789 External link 512 Glochidonol
CHEMBL469838
No. 23 No. 51
C00034390 External link 512 3-epi-Betulinic acid
CHEMBL269277
CHEMBL71690
CHEMBL519059
CHEMBL1318530
CHEMBL2005635
34 / 17 / 14 No. 23 No. 51
C00035253 External link 512 Betulonic acid
/ (+)-Betulonic acid
CHEMBL431525
CHEMBL1329485
8 / 15 / 11 No. 23 No. 51
C00042123 External link 512 3-epi-Betulin
/ (+)-3-epi-Betulin
CHEMBL23236
CHEMBL140040
CHEMBL1610940
CHEMBL2000891
CHEMBL2069124
18 / 16 / 17 No. 23 No. 51
C00042124 External link 512 3-epi-Betulinic aldehyde
CHEMBL512622
CHEMBL476675
No. 23 No. 51
C00042283 External link 512 Betulone
/ (+)-Betulone
CHEMBL469284
No. 23 No. 51
C00042563 External link 512 Glochidiol
CHEMBL470447
CHEMBL513037
No. 23 No. 51
C00042765 External link 512 Nepeticin
No. 23 No. 51
C00042919 External link 512 Rigidenol
CHEMBL513025
No. 23 No. 51

Human Protein / Gene in interactions

42 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor C00003740 C00019220 C00034390 C00035253 C00042123 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00003740 C00003749 C00034390 C00035253 C00042123 0 / 0
Q96RI1 Bile acid receptor NR1H4 C00003740 C00019220 C00034390 C00035253 C00042123 0 / 0
P11387 DNA topoisomerase 1 Isomerase C00003740 C00003749 C00034390 C00035253 C00042123 0 / 0
P02545 Prelamin-A/C Unclassified protein C00003740 C00034390 C00035253 C00042123 11 / 10
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003740 C00034390 C00042123 1 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003740 C00034390 C00042123 0 / 0
P05771 Protein kinase C beta type Alpha C00003740 C00034390 C00042123 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00003740 C00034390 C00042123 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00003740 C00034390 C00042123 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003740 C00034390 C00042123 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003740 C00034390 C00042123 0 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003740 C00034390 C00042123 0 / 1
Q02156 Protein kinase C epsilon type Eta C00003740 C00034390 C00042123 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00003740 C00042123 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00003740 C00042123 3 / 1
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003740 C00042123 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00003740 C00042123 0 / 3
O75496 Geminin Unclassified protein C00034390 C00035253 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00034390 0 / 0
P15121 Aldose reductase Enzyme C00034390 0 / 0
P08151 Zinc finger protein GLI1 Unclassified protein C00034390 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00034390 0 / 0
Q04206 Transcription factor p65 Transcription Factor C00034390 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00034390 1 / 1
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00034390 0 / 0
P15559 NAD(P)H dehydrogenase [quinone] 1 Enzyme C00034390 0 / 0
P14679 Tyrosinase Oxidoreductase C00019220 4 / 2
P08047 Transcription factor Sp1 Unclassified protein C00003749 0 / 0
Q13133 Oxysterols receptor LXR-alpha NR1H3 C00034390 0 / 0
P06746 DNA polymerase beta Enzyme C00034390 0 / 0
P55055 Oxysterols receptor LXR-beta NR1H3 C00034390 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00034390 0 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00034390 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00034390 2 / 0
Q16637 Survival motor neuron protein Unclassified protein C00035253 4 / 1
Q9UNA4 DNA polymerase iota Enzyme C00035253 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00034390 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00034390 1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00034390 0 / 0
Q9UBT2 SUMO-activating enzyme subunit 2 Enzyme C00034390 0 / 0
Q9UBE0 SUMO-activating enzyme subunit 1 Unclassified protein C00034390 0 / 0

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1499 CTNNB1, CTNNB, MRD19, armadillo catenin (cadherin-associated protein), beta 1, 88kDa C00003749
5728 PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) C00003749

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (28)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#137800 Glioma susceptibility 1; glm1 O75874
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (21)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

8 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003110 Colonic Neoplasms C00003740
D064420 Drug-Related Side Effects and Adverse Reactions C00003740
D006528 Carcinoma, Hepatocellular C00003749
D009202 Cardiomyopathies C00003749
D006937 Hypercholesterolemia C00003749
D009374 Neoplasms, Experimental C00003749
D012878 Skin Neoplasms C00003749
D014947 Wounds and Injuries C00003749