PCIDB

Stemodia foliosa

Species

KNApSAcK Entry

Organism name Stemodia foliosa
Genus Stemodia
Family Plantaginaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Stemodia
Linked NCBI taxonomy ID 225102
Linked level genus

Family

Family in NCBI taxonomy Plantaginaceae
ID 156152

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00003741 External link 512 Betulinic acid
CHEMBL269277
CHEMBL71690
CHEMBL519059
CHEMBL1318530
CHEMBL2005635
C002070
34 / 17 / 14 10 / 2 No. 23 No. 51
C00003749 External link 512 Lupeol
/ Lupenol
/ (+)-Lupenol
CHEMBL289191
CHEMBL459702
C010480
3 / 0 / 0 2 / 6 No. 23 No. 51
C00023770 External link 512 Sitosterol
/ Stigmasta-5,22-dien-3beta-ol
/ (24R)24-Ethylcholesta-5,22-dien-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00023774 External link 512 Fucostanol
/ Stigmasterol
/ Dihydro-beta-sitosterol
/ (24S)24-Ethylcholestain-3beta-ol
CHEMBL66943
CHEMBL186373
CHEMBL400247
CHEMBL1568947
D013265
5 / 0 / 0 1 / 0 No. 53 No. 11
C00038298 External link 512 6alpha-Acetoxymanoyl oxide
/ (+)-6alpha-Acetoxymanoyl oxide
CHEMBL449917
No. 70
C00038300 External link 512 6alpha-Malonyloxymanoyl oxide
/ (+)-6alpha-Malonyloxymanoyl oxide
CHEMBL480513
No. 8171

Human Protein / Gene in interactions

46 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P06746 DNA polymerase beta Enzyme C00003741 C00023770 C00023774 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00003741 C00003749 C00023774 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003741 C00023770 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003741 C00023770 1 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003741 C00023770 1 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003741 C00023770 2 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003741 C00023770 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003741 C00023770 0 / 1
P08047 Transcription factor Sp1 Unclassified protein C00003749 C00023770 0 / 0
P11387 DNA topoisomerase 1 Isomerase C00003741 C00003749 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003741 C00023770 0 / 1
Q04206 Transcription factor p65 Transcription Factor C00003741 0 / 0
P08183 Multidrug resistance protein 1 drug C00023770 1 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00023774 0 / 0
P15559 NAD(P)H dehydrogenase [quinone] 1 Enzyme C00003741 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00023770 3 / 2
P02545 Prelamin-A/C Unclassified protein C00003741 11 / 10
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00003741 0 / 0
P08151 Zinc finger protein GLI1 Unclassified protein C00003741 0 / 0
O75496 Geminin Unclassified protein C00003741 0 / 0
P15121 Aldose reductase Enzyme C00003741 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00003741 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00003741 0 / 0
Q02156 Protein kinase C epsilon type Eta C00003741 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00003741 1 / 1
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00003741 0 / 0
P00734 Prothrombin S1A C00023770 4 / 2
P14679 Tyrosinase Oxidoreductase C00023770 4 / 2
Q96RI1 Bile acid receptor NR1H4 C00003741 0 / 0
Q13133 Oxysterols receptor LXR-alpha NR1H3 C00003741 0 / 0
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor C00003741 0 / 0
P55055 Oxysterols receptor LXR-beta NR1H3 C00003741 0 / 0
P03372 Estrogen receptor NR3A1 C00023770 1 / 1
P09884 DNA polymerase alpha catalytic subunit Transferase C00023774 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00003741 0 / 0
P05771 Protein kinase C beta type Alpha C00003741 0 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00003741 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00023770 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00023770 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00003741 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00023770 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00003741 1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00003741 0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00023774 0 / 0
Q9UBT2 SUMO-activating enzyme subunit 2 Enzyme C00003741 0 / 0
Q9UBE0 SUMO-activating enzyme subunit 1 Unclassified protein C00003741 0 / 0

13 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00003741
581 BAX, BCL2L4 BCL2-associated X protein C00003741
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00003741
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00003741
840 CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) C00003741
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00003741
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00003741
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00003741
7150 TOP1, TOPI topoisomerase (DNA) I (EC:5.99.1.2) C00003741
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00003741
1499 CTNNB1, CTNNB, MRD19, armadillo catenin (cadherin-associated protein), beta 1, 88kDa C00003749
5728 PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) C00003749
10599 SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 solute carrier organic anion transporter family, member 1B1 C00023774

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (32)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#218030 Apparent mineralocorticoid excess; ame P80365
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#137800 Glioma susceptibility 1; glm1 O75874
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (23)

KEGG name UniProt
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

8 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D008103 Liver Cirrhosis C00003741
D008545 Melanoma C00003741
D006528 Carcinoma, Hepatocellular C00003749
D009202 Cardiomyopathies C00003749
D006937 Hypercholesterolemia C00003749
D009374 Neoplasms, Experimental C00003749
D012878 Skin Neoplasms C00003749
D014947 Wounds and Injuries C00003749