Species

KNApSAcK Entry

Organism name Haplopappus bailahuen
Genus Haplopappus
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Haplopappus
Linked NCBI taxonomy ID 71051
Linked level genus

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005730 External link 512 Myricitrin
/ Myricetin 3-O-rhamnoside
/ Myricetin 3-O-alpha-L-rhamnoside
/ Myricetin 3-O-alpha-L-rhamnopyranoside
CHEMBL454576
CHEMBL522983
CHEMBL1599224
C008577
25 / 11 / 11 No. 2 No. 15
C00005728 External link 512 Myricetin 3-galactoside
/ Myricetin 3-O-galactoside
CHEMBL462244
CHEMBL1221722
No. 2 No. 15
C00004635 External link 512 Isorhamnetin
/ 3'-O-Methylquercetin
/ 3,4',5,7-Tetrahydroxy-3'-methoxyflavone
/ 3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one
CHEMBL379064
C047368
12 / 10 / 13 10 / 0 No. 3 No. 15
C00003867 External link 512 Velutin
/ Flavoyadorigenin B
/ Luteolin 7,3'-dimethyl ether
/ 5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
CHEMBL508292
No. 3 No. 15

Human Protein / Gene in interactions

34 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P39748 Flap endonuclease 1 Enzyme C00004635 C00005730 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00004635 C00005730 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00004635 C00005730 0 / 0
P04745 Alpha-amylase 1 Enzyme C00004635 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00005730 1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00005730 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00004635 1 / 1
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00004635 0 / 0
P07237 Protein disulfide-isomerase Enzyme C00005730 0 / 0
P04792 Heat shock protein beta-1 Unclassified protein C00004635 2 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00005730 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00005730 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00005730 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00005730 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00005730 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00005730 0 / 0
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00004635 4 / 4
P06746 DNA polymerase beta Enzyme C00005730 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00004635 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00005730 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00005730 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00004635 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00005730 4 / 3
P34949 Mannose-6-phosphate isomerase Enzyme C00005730 1 / 1
Q99700 Ataxin-2 Unclassified protein C00005730 1 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme C00005730 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00005730 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00005730 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00005730 1 / 1
O00255 Menin Unclassified protein C00004635 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00004635 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00005730 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00005730 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00005730 0 / 0

10 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00004635
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00004635
196 AHR, bHLHe76 aryl hydrocarbon receptor C00004635
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00004635
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00004635
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00004635
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00004635
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00004635
4973 OLR1, CLEC8A, LOX1, LOXIN, SCARE1, SLOX1 oxidized low density lipoprotein (lectin-like) receptor 1 C00004635
7031 TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 trefoil factor 1 C00004635

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (21)

OMIM preferred title UniProt
#606595 Charcot-marie-tooth disease, axonal, type 2f; cmt2f P04792
#602579 Congenital disorder of glycosylation, type ib; cdg1b P34949
#600274 Frontotemporal dementia; ftd P10636
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#608634 Neuronopathy, distal hereditary motor, type iib; hmn2b P04792
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (23)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00856 Distal hereditary motor neuropathies (dHMN) P04792 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00118 Congenital disorders of glycosylation (CDG) type I P34949 (related)
H00192 Xanthinuria P47989 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)