Species

KNApSAcK Entry

Organism name Ribes viscosissimum
Genus Ribes
Family Grossulariaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Ribes viscosissimum
Linked NCBI taxonomy ID 175237
Linked level species

Family

Family in NCBI taxonomy Grossulariaceae
ID 23066

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00004533 External link 512 Galangin
/ Norizalpinin
/ 3,5,7-Trihydroxyflavone
/ 3,5,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one
CHEMBL309490
C037032
35 / 34 / 29 15 / 4 No. 76 No. 15

Human Protein / Gene in interactions

35 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00004533 1 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00004533 3 / 0
O75795 UDP-glucuronosyltransferase 2B17 Enzyme C00004533 1 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00004533 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00004533 1 / 1
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00004533 0 / 0
P08183 Multidrug resistance protein 1 drug C00004533 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00004533 0 / 1
P11388 DNA topoisomerase 2-alpha Isomerase C00004533 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00004533 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00004533 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00004533 2 / 0
O75496 Geminin Unclassified protein C00004533 0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00004533 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00004533 4 / 2
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00004533 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00004533 0 / 1
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00004533 2 / 2
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00004533 4 / 4
P06276 Cholinesterase Hydrolase C00004533 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00004533 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00004533 0 / 0
P22303 Acetylcholinesterase Hydrolase C00004533 1 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00004533 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00004533 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00004533 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00004533 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00004533 5 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00004533 4 / 3
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00004533 0 / 0
P10275 Androgen receptor NR3C4 C00004533 3 / 4
P06239 Tyrosine-protein kinase Lck Src C00004533 0 / 1
O00255 Menin Unclassified protein C00004533 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00004533 1 / 2
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00004533 0 / 0

15 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00004533
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00004533
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00004533
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00004533
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00004533
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00004533
2034 EPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73 endothelial PAS domain protein 1 C00004533
2950 GSTP1, DFN7, FAEES3, GST3, GSTP, PI glutathione S-transferase pi 1 (EC:2.5.1.18) C00004533
3091 HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) C00004533
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00004533
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00004533
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00004533
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00004533
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00004533
7366 UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) C00004533

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (34)

OMIM preferred title UniProt
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#612560 Bone mineral density quantitative trait locus 12; bmnd12 O75795
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#114500 Colorectal cancer; crc P84022
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#143500 Gilbert syndrome P22309
P22310
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#145000 Hyperparathyroidism 1; hrpt1 O00255
#612244 Inflammatory bowel disease 13; ibd13 P08183
#601626 Leukemia, acute myeloid; aml P36888
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303

KEGG DISEASE (29)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00208 Hyperbilirubinemia P22309 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
H00027 Ovarian cancer P38398 (related)
H00031 Breast cancer P38398 (related)
H00192 Xanthinuria P47989 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)

Diseases related to CTD interactions

4 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006943 Hyperglycemia C00004533
D006946 Hyperinsulinism C00004533
D015228 Hypertriglyceridemia C00004533
D007333 Insulin Resistance C00004533