Archangelicia tschimganica
Metabolite list (3)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002488
|
Osthol
/ Osthole |
CHEMBL52229
|
C046627
|
12 / 6 / 5 | 7 / 4 | No. 466 | No. 25 |
|
|
C00000582
|
Xanthotoxol
/ 8-Hydroxyanthotoxol |
CHEMBL1192
|
C021768
|
2 / 2 / 2 | No. 1282 | No. 25 |
|
|
|
C00034737
|
Umbelliprenin
|
CHEMBL156127
|
8 / 3 / 3 | No. 2038 |
|
Human Protein / Gene in interactions
18 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002488 C00034737 | 0 / 0 |
| P56817 | Beta-secretase 1 | A1A | C00000582 C00002488 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00002488 C00034737 | 0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00000582 C00034737 | 2 / 2 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00002488 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00002488 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00034737 | 0 / 0 |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | C00002488 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00002488 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002488 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002488 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00002488 | 6 / 4 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00034737 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002488 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00034737 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00034737 | 0 / 0 |
| O14980 | Exportin-1 | Unclassified protein | C00002488 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00034737 | 1 / 1 |
7 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 2180 | ACSL1, ACS1, FACL1, FACL2, LACS, LACS1, LACS2 | acyl-CoA synthetase long-chain family member 1 (EC:6.2.1.3) |
C00002488
|
| 1374 | CPT1A, CPT1, CPT1-L, L-CPT1 | carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) |
C00002488
|
| 4313 | MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) |
C00002488
|
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00002488
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00002488
|
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00002488
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00002488
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (9)
| OMIM | preferred title | UniProt |
|---|---|---|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
KEGG DISEASE (8)
| KEGG | name | UniProt |
|---|---|---|
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|