Species

KNApSAcK Entry

Organism name Baccharis salicina
Genus Baccharis
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Baccharis
Linked NCBI taxonomy ID 41487
Linked level genus

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00004694 External link 512 Centaureidin
/ Desmethoxycentaureidine
/ Quercetagetin 3,4',6-trimethyl ether
/ 5,7,3'-Trihydroxy-3,6,4'-trimethoxyflavone
/ 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6-dimethoxy-4H-1-benzopyran-4-one
CHEMBL77552
C083161
24 / 14 / 6 No. 3 No. 15
C00004709 External link 512 Quercetagetin 6,7,3',4'-tetramethyl ether
/ 2-(3,4-Dimethoxyphenyl)-3,5-dihydroxy-6,7-dimethoxy-4H-1-benzopyran-4-one
No. 8 No. 15
C00019064 External link 512 Oleanolic acid
/ Astrantiagenin C
/ Virgaureagenin B
/ 3beta-Hydroxyolean-12-en-28-oic acid
CHEMBL56615
CHEMBL168
CHEMBL180553
CHEMBL365375
CHEMBL486382
CHEMBL1413646
CHEMBL1436454
D009828
30 / 8 / 12 21 / 15 No. 13 No. 51
C00019525 External link 512 Maniladiol
/ 3beta,16beta-Dihydroxyolean-12-ene
CHEMBL1977415
C068534
No. 13 No. 51
C00020590 External link 512 Bacchariolide B
No. 214 No. 38
C00020696 External link 512 Bacchariolide A
No. 214 No. 38

Human Protein / Gene in interactions

53 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75496 Geminin Unclassified protein C00004694 C00019064 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00019064 0 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00019064 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00019064 0 / 3
P06746 DNA polymerase beta Enzyme C00019064 0 / 0
Q06124 Tyrosine-protein phosphatase non-receptor type 11 Tyr C00019064 4 / 2
P24666 Low molecular weight phosphotyrosine protein phosphatase Tyr C00019064 0 / 0
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor C00019064 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00019064 0 / 0
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00019064 0 / 0
P10586 Receptor-type tyrosine-protein phosphatase F Receptor tyrosine-protein phosphatase C00019064 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00019064 0 / 0
P39748 Flap endonuclease 1 Enzyme C00004694 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00019064 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00004694 2 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00019064 0 / 0
P15121 Aldose reductase Enzyme C00019064 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00019064 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00004694 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00004694 1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00019064 0 / 0
P51843 Nuclear receptor subfamily 0 group B member 1 Nuclear hormone receptor subfamily 0 group B member 1 C00004694 2 / 2
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00019064 2 / 2
Q96RI1 Bile acid receptor NR1H4 C00019064 0 / 0
P18433 Receptor-type tyrosine-protein phosphatase alpha Receptor tyrosine-protein phosphatase C00019064 0 / 0
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00019064 0 / 0
Q99700 Ataxin-2 Unclassified protein C00004694 1 / 1
P35228 Nitric oxide synthase, inducible Enzyme C00019064 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00019064 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00019064 0 / 0
P17706 Tyrosine-protein phosphatase non-receptor type 2 Tyr C00019064 0 / 1
P29350 Tyrosine-protein phosphatase non-receptor type 6 Tyr C00019064 0 / 0
P04054 Phospholipase A2 Enzyme C00019064 0 / 0
P23469 Receptor-type tyrosine-protein phosphatase epsilon Receptor tyrosine-protein phosphatase C00019064 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00004694 1 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00019064 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00019064 1 / 4
Q13748 Tubulin alpha-3C/D chain Structural C00004694 0 / 0
P68366 Tubulin alpha-4A chain Structural C00004694 0 / 0
Q9H4B7 Tubulin beta-1 chain Structural C00004694 1 / 0
P04350 Tubulin beta-4A chain Structural C00004694 2 / 0
Q3ZCM7 Tubulin beta-8 chain Structural C00004694 0 / 0
P07437 Tubulin beta chain Structural C00004694 0 / 0
Q71U36 Tubulin alpha-1A chain Structural C00004694 1 / 1
P68371 Tubulin beta-4B chain Structural C00004694 0 / 0
Q13509 Tubulin beta-3 chain Structural C00004694 2 / 1
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00004694 0 / 0
P68363 Tubulin alpha-1B chain Unclassified protein C00004694 0 / 0
Q13885 Tubulin beta-2A chain Structural C00004694 0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein C00004694 0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein C00004694 0 / 0
Q9BUF5 Tubulin beta-6 chain Structural C00004694 0 / 0
Q9BVA1 Tubulin beta-2B chain Structural C00004694 1 / 0

21 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
177 AGER, RAGE advanced glycosylation end product-specific receptor C00019064
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00019064
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00019064
847 CAT catalase (EC:1.11.1.6) C00019064
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00019064
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00019064
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00019064
3065 HDAC1, GON-10, HD1, RPD3, RPD3L1 histone deacetylase 1 (EC:3.5.1.98) C00019064
3146 HMGB1, HMG1, HMG3, SBP-1 high mobility group box 1 C00019064
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00019064
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00019064
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00019064
4233 MET, AUTS9, HGFR, RCCP2, c-Met met proto-oncogene (EC:2.7.10.1) C00019064
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00019064
5052 PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2 peroxiredoxin 1 (EC:1.11.1.15) C00019064
5728 PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) C00019064
6401 SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 selectin E C00019064
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00019064
7150 TOP1, TOPI topoisomerase (DNA) I (EC:5.99.1.2) C00019064
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00019064
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00019064

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (22)

OMIM preferred title UniProt
#300018 46,xy sex reversal 2; srxy2 P51843
#300200 Adrenal hypoplasia, congenital; ahc P51843
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#114500 Colorectal cancer; crc P84022
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#137800 Glioma susceptibility 1; glm1 O75874
#607785 Juvenile myelomonocytic leukemia; jmml Q06124
#151100 Leopard syndrome 1 Q06124
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#611603 Lissencephaly 3; lis3 Q71U36
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#611162 Malaria, susceptibility to P35228
#156250 Metachondromatosis; metcds Q06124
#163950 Noonan syndrome 1; ns1 Q06124
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (18)

KEGG name UniProt
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H00408 Type I diabetes mellitus P17706 (related)
H00017 Esophageal cancer P35228 (related)
P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00552 Glycerol kinase deficiency (GKD) P51843 (related)
H00607 46,XY disorders of sex development (Disorders of gonadal development) P51843 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00523 Noonan syndrome and related disorders Q06124 (related)
H01018 Metachondromatosis Q06124 (related)
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

15 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002252 Carbon Tetrachloride Poisoning C00019064
D056486 Drug-Induced Liver Injury C00019064
D050171 Dyslipidemias C00019064
D018149 Glucose Intolerance C00019064
D006949 Hyperlipidemias C00019064
D007249 Inflammation C00019064
D007674 Kidney Diseases C00019064
D008103 Liver Cirrhosis C00019064
D008106 Liver Cirrhosis, Experimental C00019064
D008107 Liver Diseases C00019064
D017202 Myocardial Ischemia C00019064
D009369 Neoplasms C00019064
D009765 Obesity C00019064
D011041 Poisoning C00019064
D011230 Precancerous Conditions C00019064