Zingiber zerumbet
Species
KNApSAcK Entry
| Organism name | Zingiber zerumbet |
|---|---|
| Genus | Zingiber |
| Family | Zingiberaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Zingiber zerumbet |
|---|---|
| Linked NCBI taxonomy ID | 311405 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Zingiberaceae |
|---|---|
| ID | 4642 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Liliopsida |
|---|---|
| ID | 4447 |
Metabolite list (13)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00005140
|
Afzelin
/ Kaempferol 3-O-alpha-rhamnoside / Kaempferol 3-O-alpha-L-rhamnopyranoside |
CHEMBL240528
CHEMBL515798 |
C477954
|
4 / 2 / 2 | No. 2 | No. 15 |
|
|
|
C00005860
|
Kaempferol 3-(2''-acetylrhamnoside)
|
CHEMBL469431
|
2 / 1 / 1 | No. 2 | No. 15 |
|
||
|
C00005862
|
Kaempferol 3-(4''-acetylrhamnoside)
|
CHEMBL470049
|
2 / 1 / 1 | No. 2 | No. 15 |
|
||
|
C00005861
|
Kaempferol 3-(3''-acetylrhamnoside)
/ Kaempferol 3-O-(3'-O-acetyl-alpha-L-rhamnopyranoside) |
CHEMBL470048
|
2 / 1 / 1 | No. 2 | No. 15 |
|
||
|
C00005865
|
Kaempferol 3-(2'',4''-diacetylrhamnoside)
|
CHEMBL471074
|
2 / 1 / 1 | No. 330 |
|
|||
|
C00005866
|
Kaempferol 3-(3'',4''-diacetylrhamnoside)
|
CHEMBL240954
|
71 / 17 / 11 | No. 330 |
|
|||
|
C00012464
|
Humulenol I
/ (+)-Humulenol I |
No. 1421 | No. 38 |
|
||||
|
C00012463
|
Humulenol
/ Humulenol II / (+)-Humulenol II |
No. 1421 | No. 38 |
|
||||
|
C00012444
|
Humulene oxide II
/ Humulene epoxide II / Humulene II epoxide / Humulene 6,7-epoxide / Humulene 1,2-epoxide / (-)-Humulene epoxide II |
No. 1728 |
|
|||||
|
C00012468
|
Zerumbone oxide
|
CHEMBL512339
CHEMBL1240930 |
2 / 1 / 1 | No. 1728 |
|
|||
|
C00012443
|
Humulene oxide
/ Humulene oxide I / Humulene epoxide / Humulene monoxide / Humulene I epoxide / Humulene epoxide I / alpha-Humulene oxide |
CHEMBL509909
|
No. 1728 |
|
||||
|
C00012467
|
Zerumbone
|
CHEMBL245412
|
C403304
|
4 / 2 / 2 | 27 / 1 | No. 2272 |
|
|
|
C00031443
|
Zerumboneoxide
|
CHEMBL471475
CHEMBL465152 |
1 / 0 / 0 | No. 3222 |
|
Human Protein / Gene in interactions
76 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00005140 C00005860 C00005861 C00005862 C00005865 C00005866 C00012467 C00012468 | 1 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00005140 C00005860 C00005861 C00005862 C00005865 C00005866 C00012467 C00012468 | 0 / 1 |
| P51812 | Ribosomal protein S6 kinase alpha-3 | Rskb | C00005866 | 2 / 2 |
| Q8TDX7 | Serine/threonine-protein kinase Nek7 | Nek | C00005866 | 0 / 0 |
| Q15759 | Mitogen-activated protein kinase 11 | p38 | C00005866 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00005866 | 0 / 0 |
| O15530 | 3-phosphoinositide-dependent protein kinase 1 | Pdk1 | C00005866 | 0 / 0 |
| P41240 | Tyrosine-protein kinase CSK | Csk | C00005866 | 0 / 0 |
| P45984 | Mitogen-activated protein kinase 9 | Jnk | C00005866 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00005866 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00005866 | 0 / 0 |
| O14757 | Serine/threonine-protein kinase Chk1 | Chk1 | C00005866 | 0 / 0 |
| Q8IWQ3 | Serine/threonine-protein kinase BRSK2 | CAMK serine/threonine protein kinase BRSK subfamily | C00005866 | 0 / 0 |
| P27448 | MAP/microtubule affinity-regulating kinase 3 | CAMK serine/threonine protein kinase MARK subfamily | C00005866 | 0 / 0 |
| Q05513 | Protein kinase C zeta type | Iota | C00005866 | 0 / 0 |
| P11309 | Serine/threonine-protein kinase pim-1 | Pim | C00005866 | 0 / 0 |
| P23443 | Ribosomal protein S6 kinase beta-1 | p70 | C00005866 | 0 / 0 |
| Q9UQB9 | Aurora kinase C | Aur | C00005866 | 1 / 1 |
| Q9HBH9 | MAP kinase-interacting serine/threonine-protein kinase 2 | CAMK serine/threonine protein kinase MNK subfamily | C00005866 | 0 / 0 |
| Q9NQU5 | Serine/threonine-protein kinase PAK 6 | STE serine/threonine protein kinase PAKB subfamily | C00005866 | 0 / 0 |
| Q16644 | MAP kinase-activated protein kinase 3 | CAMK serine/threonine protein kinase MAPKAPK | C00005866 | 0 / 0 |
| Q9H422 | Homeodomain-interacting protein kinase 3 | CMGC dual-specificity kinase HIPK | C00005866 | 0 / 0 |
| Q14680 | Maternal embryonic leucine zipper kinase | Melk | C00005866 | 0 / 0 |
| Q15746 | Myosin light chain kinase, smooth muscle | Mlck | C00005866 | 1 / 1 |
| Q13188 | Serine/threonine-protein kinase 3 | STE serine/threonine protein kinase MST subfamily | C00005866 | 0 / 0 |
| P31751 | RAC-beta serine/threonine-protein kinase | Akt | C00005866 | 2 / 2 |
| O75582 | Ribosomal protein S6 kinase alpha-5 | CAMK serine/threonine protein kinase MSKB subfamily | C00005866 | 0 / 0 |
| O14920 | Inhibitor of nuclear factor kappa-B kinase subunit beta | Other serine/threonine protein kinase | C00005866 | 0 / 0 |
| Q16513 | Serine/threonine-protein kinase N2 | Pkn | C00005866 | 0 / 0 |
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00005866 | 0 / 0 |
| P04278 | Sex hormone-binding globulin | Secreted protein | C00031443 | 0 / 0 |
| Q8N5S9 | Calcium/calmodulin-dependent protein kinase kinase 1 | META serine/threonine protein kinase subfamily | C00005866 | 0 / 0 |
| Q9P286 | Serine/threonine-protein kinase PAK 7 | STE serine/threonine protein kinase PAKB subfamily | C00005866 | 0 / 0 |
| Q96SB4 | SRSF protein kinase 1 | Srpk | C00005866 | 0 / 0 |
| Q92630 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | CMGC dual-specificity kinase DYRK2 | C00005866 | 0 / 0 |
| O43781 | Dual specificity tyrosine-phosphorylation-regulated kinase 3 | CMGC dual-specificity kinase DYRK2 | C00005866 | 0 / 0 |
| O96013 | Serine/threonine-protein kinase PAK 4 | STE serine/threonine protein kinase PAKB subfamily | C00005866 | 0 / 0 |
| P08151 | Zinc finger protein GLI1 | Unclassified protein | C00012467 | 0 / 0 |
| P10070 | Zinc finger protein GLI2 | Unclassified protein | C00012467 | 1 / 1 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00005866 | 0 / 0 |
| Q15418 | Ribosomal protein S6 kinase alpha-1 | Rskb | C00005866 | 0 / 0 |
| O15264 | Mitogen-activated protein kinase 13 | p38 | C00005866 | 0 / 0 |
| P53779 | Mitogen-activated protein kinase 10 | Jnk | C00005866 | 0 / 1 |
| P51955 | Serine/threonine-protein kinase Nek2 | Nek | C00005866 | 0 / 0 |
| Q96RR4 | Calcium/calmodulin-dependent protein kinase kinase 2 | META serine/threonine protein kinase subfamily | C00005866 | 0 / 0 |
| Q9BUB5 | MAP kinase-interacting serine/threonine-protein kinase 1 | CAMK serine/threonine protein kinase MNK subfamily | C00005866 | 0 / 0 |
| P16083 | Ribosyldihydronicotinamide dehydrogenase [quinone] | Enzyme | C00005140 | 0 / 0 |
| P48730 | Casein kinase I isoform delta | Ck1 | C00005866 | 1 / 0 |
| Q96GD4 | Aurora kinase B | Aur | C00005866 | 0 / 0 |
| P49137 | MAP kinase-activated protein kinase 2 | CAMK serine/threonine protein kinase MAPKAPK | C00005866 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00005866 | 0 / 0 |
| P45983 | Mitogen-activated protein kinase 8 | Jnk | C00005866 | 0 / 0 |
| P53350 | Serine/threonine-protein kinase PLK1 | PLK serine/threonine protein kinase subfamily | C00005866 | 0 / 0 |
| Q8IW41 | MAP kinase-activated protein kinase 5 | CAMK serine/threonine protein kinase MAPKAPK | C00005866 | 0 / 0 |
| O75116 | Rho-associated protein kinase 2 | Rock | C00005866 | 0 / 0 |
| P31749 | RAC-alpha serine/threonine-protein kinase | Akt | C00005866 | 4 / 1 |
| O00141 | Serine/threonine-protein kinase Sgk1 | AGC serine/threonine protein kinase SGK subfamily | C00005866 | 0 / 0 |
| Q9P1W9 | Serine/threonine-protein kinase pim-2 | Pim | C00005866 | 0 / 0 |
| Q02750 | Dual specificity mitogen-activated protein kinase kinase 1 | Ste7 | C00005866 | 1 / 1 |
| P98170 | E3 ubiquitin-protein ligase XIAP | Other cytosolic protein | C00005140 | 1 / 1 |
| Q9HC98 | Serine/threonine-protein kinase Nek6 | Nek | C00005866 | 0 / 0 |
| Q9H2X6 | Homeodomain-interacting protein kinase 2 | CMGC dual-specificity kinase HIPK | C00005866 | 0 / 0 |
| O96017 | Serine/threonine-protein kinase Chk2 | Rad53 | C00005866 | 4 / 1 |
| Q14012 | Calcium/calmodulin-dependent protein kinase type 1 | Camk1 | C00005866 | 0 / 0 |
| P17612 | cAMP-dependent protein kinase catalytic subunit alpha | Pka | C00005866 | 0 / 0 |
| Q13627 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | CMGC dual-specificity kinase DYRK1 | C00005866 | 1 / 0 |
| P53778 | Mitogen-activated protein kinase 12 | p38 | C00005866 | 0 / 0 |
| O00418 | Eukaryotic elongation factor 2 kinase | Atypical serine/threonine protein kinase alpha subfamily | C00005866 | 0 / 0 |
| Q8TD08 | Mitogen-activated protein kinase 15 | Mapk | C00005866 | 0 / 0 |
| Q86V86 | Serine/threonine-protein kinase pim-3 | Pim | C00005866 | 0 / 0 |
| P20248 | Cyclin-A2 | Other cytosolic protein | C00005866 | 0 / 0 |
| P78396 | Cyclin-A1 | Other cytosolic protein | C00005866 | 0 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00005866 | 0 / 0 |
| P68400 | Casein kinase II subunit alpha | Ck2 | C00005866 | 0 / 0 |
| P19784 | Casein kinase II subunit alpha' | Ck2 | C00005866 | 0 / 0 |
| P67870 | Casein kinase II subunit beta | REG serine/threonine protein kinase family | C00005866 | 0 / 0 |
27 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00012467
|
| 597 | BCL2A1, ACC-1, ACC-2, BCL2L5, BFL1, GRS, HBPA1 | BCL2-related protein A1 |
C00012467
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00012467
|
| 329 | BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 | baculoviral IAP repeat containing 2 |
C00012467
|
| 330 | BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 | baculoviral IAP repeat containing 3 |
C00012467
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00012467
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00012467
|
| 8837 | CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS | CASP8 and FADD-like apoptosis regulator |
C00012467
|
| 1147 | CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16 | conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) |
C00012467
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00012467
|
| 3551 | IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) |
C00012467
|
| 9020 | MAP3K14, FTDCR1B, HS, HSNIK, NIK | mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25) |
C00012467
|
| 4314 | MMP3, CHDS6, MMP-3, SL-1, STMY, STMY1, STR1 | matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17) |
C00012467
|
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00012467
|
| 4609 | MYC, MRTL, MYCC, bHLHe39, c-Myc | v-myc avian myelocytomatosis viral oncogene homolog |
C00012467
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00012467
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00012467
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00012467
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00012467
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00012467
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00012467
|
| 7132 | TNFRSF1A, CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60 | tumor necrosis factor receptor superfamily, member 1A |
C00012467
|
| 8717 | TRADD, Hs.89862 | TNFRSF1A-associated via death domain |
C00012467
|
| 7185 | TRAF1, EBI6, MGC:10353 | TNF receptor-associated factor 1 |
C00012467
|
| 7186 | TRAF2, MGC:45012, TRAP, TRAP3 | TNF receptor-associated factor 2 |
C00012467
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00012467
|
| 331 | XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 | X-linked inhibitor of apoptosis |
C00012467
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (19)
| OMIM | preferred title | UniProt |
|---|---|---|
| #615224 | Advanced sleep phase syndrome, familial, 2; fasps2 |
P48730
|
| #613780 | Aortic aneurysm, familial thoracic 7; aat7 |
Q15746
|
| #114480 | Breast cancer |
O96017
P31749 |
| #615279 | Cardiofaciocutaneous syndrome 3; cfc3 |
Q02750
|
| #303600 | Coffin-lowry syndrome; cls |
P51812
|
| #114500 | Colorectal cancer; crc |
P31749
|
| #615109 | Cowden syndrome 6; cws6 |
P31749
|
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm |
P31751
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #610829 | Holoprosencephaly 9; hpe9 |
P10070
|
| #240900 | Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh |
P31751
|
| #609265 | Li-fraumeni syndrome 2; lfs2 |
O96017
|
| #300635 | Lymphoproliferative syndrome, x-linked, 2; xlp2 |
P98170
|
| #614104 | Mental retardation, autosomal dominant 7; mrd7 |
Q13627
|
| #300844 | Mental retardation, x-linked 19; mrx19 |
P51812
|
| #259500 | Osteogenic sarcoma |
O96017
|
| #176807 | Prostate cancer |
O96017
|
| #176920 | Proteus syndrome |
P31749
|
| #243060 | Spermatogenic failure 5; spgf5 |
Q9UQB9
|
KEGG DISEASE (13)
| KEGG | name | UniProt |
|---|---|---|
| H00881 | Li-Fraumeni syndrome |
O96017
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00267 | Holoprosencephaly (HPE) |
P10070
(related)
|
| H00539 | PTEN hamartoma tumor syndrome (PHTS) |
P31749
(related)
|
| H00027 | Ovarian cancer |
P31751
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P31751
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P51812
(related)
|
| H00574 | Coffin-Lowry syndrome (CLS) |
P51812
(related)
|
| H00606 | Early infantile epileptic encephalopathy |
P53779
(related)
|
| H00107 | Other well-defined immunodeficiency syndromes |
P98170
(related)
|
| H00523 | Noonan syndrome and related disorders |
Q02750
(related)
|
| H00801 | Familial thoracic aortic aneurysm and dissection (TAAD) |
Q15746
(related)
|
| H01282 | Spermatogenic failure |
Q9UQB9
(related)
|