Mallotus metcalfianus
Species
KNApSAcK Entry
| Organism name | Mallotus metcalfianus |
|---|---|
| Genus | Mallotus |
| Family | Euphorbiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Mallotus metcalfianus |
|---|---|
| Linked NCBI taxonomy ID | 463330 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Euphorbiaceae |
|---|---|
| ID | 3977 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (4)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00005140
|
Afzelin
/ Kaempferol 3-O-alpha-rhamnoside / Kaempferol 3-O-alpha-L-rhamnopyranoside |
CHEMBL240528
CHEMBL515798 |
C477954
|
4 / 2 / 2 | No. 2 | No. 15 |
|
|
|
C00005374
|
Quercetin
|
CHEMBL82242
CHEMBL479232 CHEMBL1437696 |
C012526
|
14 / 2 / 2 | 2 / 1 | No. 2 | No. 15 |
|
|
C00048337
|
Blumenol C glucoside
|
No. 225 |
|
|||||
|
C00034325
|
E-Ferulic acid
/ (E)-Ferulic acid / trans-Ferulic acid / 4-Hydroxy-3-methoxy-(E)-cinnamic acid |
CHEMBL32749
|
110 / 52 / 40 | No. 1366 | No. 6 |
|
Human Protein / Gene in interactions
124 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00005140 C00034325 | 1 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00005374 C00034325 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00005140 C00034325 | 0 / 1 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00005374 C00034325 | 1 / 1 |
| P03372 | Estrogen receptor | NR3A1 | C00034325 | 1 / 1 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00034325 | 2 / 2 |
| P08246 | Neutrophil elastase | S1A | C00034325 | 2 / 1 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00034325 | 0 / 0 |
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00034325 | 3 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00034325 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00034325 | 0 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00034325 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00034325 | 0 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00034325 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00034325 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00034325 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00034325 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00034325 | 2 / 2 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00034325 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00034325 | 1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00034325 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00034325 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00034325 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00034325 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00034325 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00034325 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00034325 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00034325 | 0 / 0 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00034325 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00034325 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00034325 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00034325 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00034325 | 0 / 1 |
| P07237 | Protein disulfide-isomerase | Enzyme | C00005374 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00034325 | 1 / 8 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00034325 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00034325 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00034325 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00034325 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00034325 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00034325 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00034325 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00034325 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00034325 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00034325 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00034325 | 1 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00034325 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00005374 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00034325 | 1 / 2 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00034325 | 0 / 0 |
| Q8TDS4 | Hydroxycarboxylic acid receptor 2 | Hydroxycarboxylic acid receptor | C00034325 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00005374 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00034325 | 0 / 0 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00034325 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00034325 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00034325 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00034325 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00034325 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00034325 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00034325 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00034325 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00034325 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00005374 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00034325 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00034325 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00034325 | 1 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00034325 | 0 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00034325 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00034325 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00034325 | 1 / 0 |
| P03956 | Interstitial collagenase | M10A | C00034325 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00034325 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00005374 | 1 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00005374 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00034325 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00034325 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00034325 | 0 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00034325 | 4 / 2 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00034325 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00034325 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00034325 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00034325 | 1 / 0 |
| P16083 | Ribosyldihydronicotinamide dehydrogenase [quinone] | Enzyme | C00005140 | 0 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00034325 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00034325 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00034325 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00034325 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00034325 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00034325 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00034325 | 2 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00034325 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00034325 | 0 / 1 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00034325 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00034325 | 0 / 3 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00034325 | 1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00034325 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00034325 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00034325 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00034325 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00034325 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00034325 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00034325 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00034325 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00034325 | 1 / 1 |
| Q9P1W9 | Serine/threonine-protein kinase pim-2 | Pim | C00005374 | 0 / 0 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00034325 | 0 / 0 |
| P98170 | E3 ubiquitin-protein ligase XIAP | Other cytosolic protein | C00005140 | 1 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00005374 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00005374 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00005374 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00034325 | 5 / 1 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00034325 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00034325 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00034325 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00034325 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00034325 | 1 / 1 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00034325 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00034325 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00034325 | 0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00034325 | 1 / 1 |
| Q12794 | Hyaluronidase-1 | Enzyme | C00034325 | 1 / 2 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00005374 | 0 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00034325 | 3 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00005374 | 0 / 0 |
2 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00005374
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00005374
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (54)
| OMIM | preferred title | UniProt |
|---|---|---|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #600807 | Asthma, susceptibility to |
Q13093
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #147050 | Ige responsiveness, atopic; iger |
Q13093
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #300635 | Lymphoproliferative syndrome, x-linked, 2; xlp2 |
P98170
|
| #608516 | Major depressive disorder; mdd |
P08172
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #601492 | Mucopolysaccharidosis, type ix; mps9 |
Q12794
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (42)
| KEGG | name | UniProt |
|---|---|---|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
Q16790 (marker) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
|
| H00107 | Other well-defined immunodeficiency syndromes |
P98170
(related)
|
| H00133 | Mucopolysaccharidosis type IX (MPS9) |
Q12794
(related)
|
| H00421 | Mucopolysaccharidosis (MPS) |
Q12794
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|