Crataegus spp.

• Index
• Plant Species
• Natural Activity
• Metabolite list (4)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Crataegus spp.
Genus	Crataegus
Family	Rosaceae
Kingdom	Plantae

---

NCBI taxonomy

Entry

Linked NCBI taxonomy name	Crataegus
Linked NCBI taxonomy ID	23159
Linked level	genus

Family

Family in NCBI taxonomy	Rosaceae
ID	3745

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	rosids
ID	71275

Natural Activity

List (43)

Species	Activity
Crataegus spp.	Antiaggregant
Crataegus spp.	Antianginal
Crataegus spp.	Antiarrhythmic
Crataegus spp.	Antiatherosclerotic
Crataegus spp.	Anticapillary Fragility
Crataegus spp.	Antiedemic
Crataegus spp.	Antiinflammatory
Crataegus spp.	Antioxidant
Crataegus spp.	Antisclerotic
Crataegus spp.	Antiseborrheic
Crataegus spp.	Antithromboxane
Crataegus spp.	Astringent
Crataegus spp.	Bitter
Crataegus spp.	cAMP-Phosphodiesterase Inhibitor
Crataegus spp.	Cardioprotective
Crataegus spp.	Cardiotonic
Crataegus spp.	CNS Depressant
Crataegus spp.	Collagen-Sparing
Crataegus spp.	Coronary Vasodilator
Crataegus spp.	Cyanogenetic
Crataegus spp.	Depurative
Crataegus spp.	Digestive
Crataegus spp.	Diuretic
Crataegus spp.	Fumitory
Crataegus spp.	Hepatoprotective
Crataegus spp.	Hypertensive
Crataegus spp.	Hypocholesterolemic
Crataegus spp.	Hypoglycemic
Crataegus spp.	Hypotensive
Crataegus spp.	Hypotriglyceridemic
Crataegus spp.	Myocardioprotectant
Crataegus spp.	Negative Bathmotropic
Crataegus spp.	Negative Chronotropic
Crataegus spp.	Nervine
Crataegus spp.	Pancreaprotective
Crataegus spp.	Phosphodiesterase Inhibitor
Crataegus spp.	Positive Chronotropic
Crataegus spp.	Positive Dromotropic
Crataegus spp.	Positive Inotropic
Crataegus spp.	Sedative
Crataegus spp.	Stomachic
Crataegus spp.	Tonic
Crataegus spp.	Vasodilator

Metabolite list (4)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00006203	Orientin 2''-O-rhamnoside					No. 1	No. 15
C00006208	Isoorientin 2''-O-rhamnoside	CHEMBL1651280				No. 1	No. 15
C00009075	Procyanidin B1 / Epicatechin-(4beta->8)-catechin	CHEMBL38714 CHEMBL81753 CHEMBL504937 CHEMBL501490 CHEMBL447373 CHEMBL1253314 CHEMBL1590914	C479579	20 / 7 / 8		No. 16	No. 19
C00009077	Procyanidin B2 / Epicathechin-(4beta->8)-epicathechin	CHEMBL38714 CHEMBL81753 CHEMBL504937 CHEMBL501490 CHEMBL447373 CHEMBL1253314 CHEMBL1590914	C479580	20 / 7 / 8	10 / 0	No. 16	No. 19

Human Protein / Gene in interactions

20 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00009075 C00009077	1 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00009075 C00009077	0 / 1
P18433	Receptor-type tyrosine-protein phosphatase alpha	Receptor tyrosine-protein phosphatase	C00009075 C00009077	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00009075 C00009077	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00009075 C00009077	3 / 3
P23467	Receptor-type tyrosine-protein phosphatase beta	Receptor tyrosine-protein phosphatase	C00009075 C00009077	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00009075 C00009077	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00009075 C00009077	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00009075 C00009077	0 / 1
Q05513	Protein kinase C zeta type	Iota	C00009075 C00009077	0 / 0
Q04759	Protein kinase C theta type	Delta	C00009075 C00009077	0 / 1
Q02156	Protein kinase C epsilon type	Eta	C00009075 C00009077	0 / 0
O94806	Serine/threonine-protein kinase D3	Pkd	C00009075 C00009077	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00009075 C00009077	0 / 0
Q05655	Protein kinase C delta type	Delta	C00009075 C00009077	0 / 0
P05129	Protein kinase C gamma type	Alpha	C00009075 C00009077	1 / 1
P05771	Protein kinase C beta type	Alpha	C00009075 C00009077	0 / 0
P24723	Protein kinase C eta type	Eta	C00009075 C00009077	1 / 0
P41743	Protein kinase C iota type	Iota	C00009075 C00009077	0 / 0
Q15139	Serine/threonine-protein kinase D1	Pkd	C00009075 C00009077	0 / 0

10 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00009077
581	BAX, BCL2L4	BCL2-associated X protein	C00009077
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00009077
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00009077
54205	CYCS, CYC, HCS, THC4	cytochrome c, somatic	C00009077
2932	GSK3B	glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)	C00009077
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00009077
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00009077
4240	MFGE8, BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47	milk fat globule-EGF factor 8 protein	C00009077
7153	TOP2A, TOP2, TP2A	topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3)	C00009077

Related Diseases

Diseases related to proteins in ChEMBL interactions