Cotoneaster spp.
Species
KNApSAcK Entry
| Organism name | Cotoneaster spp. |
|---|---|
| Genus | Cotoneaster |
| Family | Rosaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Cotoneaster |
|---|---|
| Linked NCBI taxonomy ID | 36607 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Rosaceae |
|---|---|
| ID | 3745 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (2)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00006629
|
Fragarin
|
No. 2 | No. 15 |
|
||||
|
C00009077
|
Procyanidin B2
/ Epicathechin-(4beta->8)-epicathechin |
CHEMBL38714
CHEMBL81753 CHEMBL504937 CHEMBL501490 CHEMBL447373 CHEMBL1253314 CHEMBL1590914 |
C479580
|
20 / 7 / 8 | 10 / 0 | No. 16 | No. 19 |
|
Human Protein / Gene in interactions
20 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00009077 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00009077 | 0 / 1 |
| P18433 | Receptor-type tyrosine-protein phosphatase alpha | Receptor tyrosine-protein phosphatase | C00009077 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00009077 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00009077 | 3 / 3 |
| P23467 | Receptor-type tyrosine-protein phosphatase beta | Receptor tyrosine-protein phosphatase | C00009077 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00009077 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00009077 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00009077 | 0 / 1 |
| Q05513 | Protein kinase C zeta type | Iota | C00009077 | 0 / 0 |
| Q04759 | Protein kinase C theta type | Delta | C00009077 | 0 / 1 |
| Q02156 | Protein kinase C epsilon type | Eta | C00009077 | 0 / 0 |
| O94806 | Serine/threonine-protein kinase D3 | Pkd | C00009077 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00009077 | 0 / 0 |
| Q05655 | Protein kinase C delta type | Delta | C00009077 | 0 / 0 |
| P05129 | Protein kinase C gamma type | Alpha | C00009077 | 1 / 1 |
| P05771 | Protein kinase C beta type | Alpha | C00009077 | 0 / 0 |
| P24723 | Protein kinase C eta type | Eta | C00009077 | 1 / 0 |
| P41743 | Protein kinase C iota type | Iota | C00009077 | 0 / 0 |
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00009077 | 0 / 0 |
10 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00009077
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00009077
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00009077
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00009077
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00009077
|
| 2932 | GSK3B | glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) |
C00009077
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00009077
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00009077
|
| 4240 | MFGE8, BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47 | milk fat globule-EGF factor 8 protein |
C00009077
|
| 7153 | TOP2A, TOP2, TP2A | topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) |
C00009077
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (7)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
| #601367 | Stroke, ischemic |
P24723
|
KEGG DISEASE (8)
| KEGG | name | UniProt |
|---|---|---|
| H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00408 | Type I diabetes mellitus |
Q04759
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|