Species

KNApSAcK Entry

Organism name Streptomyces hygroscopicus DS 9751 (NRRL 3418)
Genus Streptomyces
Family Streptomycetaceae
Kingdom Bacteria

NCBI taxonomy

Entry

Linked NCBI taxonomy name Streptomyces
Linked NCBI taxonomy ID 1883
Linked level genus

Family

Family in NCBI taxonomy Streptomycetaceae
ID 2062

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Bacteria
ID 2

Plant class

Plant class
ID

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00017954 External link 512 18631RP
/ RP 18631
/ NSC 227186
/ Clorobiocin
/ Chlorobiocin
/ Antibiotic 2562A
CHEMBL303984
CHEMBL1172192
C006260
23 / 20 / 14 No. 3473

Human Protein / Gene in interactions

23 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00017954 0 / 0
Q99700 Ataxin-2 Unclassified protein C00017954 1 / 1
P06746 DNA polymerase beta Enzyme C00017954 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00017954 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00017954 2 / 2
Q92830 Histone acetyltransferase KAT2A Enzyme C00017954 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00017954 2 / 0
O75496 Geminin Unclassified protein C00017954 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00017954 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00017954 7 / 3
Q9Y253 DNA polymerase eta Enzyme C00017954 1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00017954 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00017954 0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00017954 0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00017954 1 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00017954 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00017954 4 / 3
P46063 ATP-dependent DNA helicase Q1 Enzyme C00017954 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00017954 1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00017954 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00017954 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00017954 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00017954 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (20)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#114500 Colorectal cancer; crc P84022
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (14)

KEGG name UniProt
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)