Species

KNApSAcK Entry

Organism name Parmelia pseudofatiscens
Genus Parmelia
Family Parmeliaceae
Kingdom Fungi

NCBI taxonomy

Entry

Linked NCBI taxonomy name Parmelia
Linked NCBI taxonomy ID 87260
Linked level genus

Family

Family in NCBI taxonomy Parmeliaceae
ID 78060

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Fungi
ID 4751

Plant class

Plant class
ID

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00047798 External link 512 Chloroatranorin
No. 3861
C00036782 External link 512 Parmelin
/ Atranorin
/ Usnarin acid
CHEMBL173395
C026304
2 / 0 / 1 5 / 3 No. 3861
C00017999 External link 512 NSC 249981
/ Lecanoric acid
CHEMBL1451874
C008263
10 / 8 / 13 No. 3983

Human Protein / Gene in interactions

11 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00017999 C00036782 0 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00017999 2 / 2
O75496 Geminin Unclassified protein C00017999 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00017999 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00017999 3 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00017999 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00017999 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00036782 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00017999 0 / 0
O00255 Menin Unclassified protein C00017999 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00017999 1 / 2

5 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
581 BAX, BCL2L4 BCL2-associated X protein C00036782
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00036782
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00036782
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00036782
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00036782

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (8)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#119900 Digital clubbing, isolated congenital P15428
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255

KEGG DISEASE (13)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

3 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D005157 Facial Pain C00036782
D007249 Inflammation C00036782
D009369 Neoplasms C00036782