Lolium perenne L.
Species
KNApSAcK Entry
| Organism name | Lolium perenne L. |
|---|---|
| Genus | Lolium |
| Family | Poaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Lolium perenne |
|---|---|
| Linked NCBI taxonomy ID | 4522 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Poaceae |
|---|---|
| ID | 4479 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Liliopsida |
|---|---|
| ID | 4447 |
Metabolite list (7)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00036257
|
25-Methylcastasterone
|
No. 68 | No. 11 |
|
||||
|
C00023584
|
beta-Paxitriol
|
No. 819 |
|
|||||
|
C00023583
|
alpha-Paxitriol
|
No. 819 |
|
|||||
|
C00023582
|
Paxilline
|
CHEMBL410063
CHEMBL1372110 CHEMBL1396845 |
C048220
|
27 / 25 / 19 | 5 / 0 | No. 819 |
|
|
|
C00023578
|
Lolitriol
|
No. 2224 |
|
|||||
|
C00023577
|
Lolitrem E
/ Lolitrem C |
No. 2224 |
|
|||||
|
C00019144
|
Loliolide
/ (-)-Loliolide |
CHEMBL227113
CHEMBL446471 |
C030425
|
1 / 2 / 2 | No. 2667 |
|
Human Protein / Gene in interactions
28 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00023582 | 1 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00023582 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00023582 | 1 / 1 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00023582 | 2 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00023582 | 6 / 4 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00023582 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00023582 | 0 / 1 |
| P42858 | Huntingtin | Unclassified protein | C00023582 | 1 / 1 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00023582 | 2 / 0 |
| O75496 | Geminin | Unclassified protein | C00023582 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00023582 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00023582 | 1 / 2 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00023582 | 0 / 0 |
| Q99816 | Tumor susceptibility gene 101 protein | Unclassified protein | C00023582 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00019144 | 2 / 2 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00023582 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00023582 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00023582 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00023582 | 0 / 1 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00023582 | 1 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00023582 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00023582 | 4 / 3 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00023582 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00023582 | 1 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00023582 | 1 / 0 |
| Q8IUX4 | DNA dC->dU-editing enzyme APOBEC-3F | Enzyme | C00023582 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00023582 | 2 / 5 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00023582 | 1 / 1 |
5 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00023582
|
| 1385 | CREB1, CREB | cAMP responsive element binding protein 1 |
C00023582
|
| 10062 | NR1H3, LXR-a, LXRA, RLD-1 | nuclear receptor subfamily 1, group H, member 3 |
C00023582
|
| 5728 | PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 | phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) |
C00023582
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00023582
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (27)
| OMIM | preferred title | UniProt |
|---|---|---|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #143100 | Huntington disease; hd |
P42858
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
KEGG DISEASE (21)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |