Alternaria tenuis NRRL 5255,5872,5873
Species
KNApSAcK Entry
| Organism name | Alternaria tenuis NRRL 5255,5872,5873 |
|---|---|
| Genus | Alternaria |
| Family | Dothideomycetes |
| Kingdom | Fungi |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Alternaria |
|---|---|
| Linked NCBI taxonomy ID | 5598 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Pleosporaceae |
|---|---|
| ID | 28556 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Fungi |
|---|---|
| ID | 4751 |
Plant class
| Plant class | |
|---|---|
| ID |
Metabolite list (1)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00023663
|
Alternariol
/ 3,4',5-Trihydroxy-6'-methyl-dibenzo[a]pyrone |
CHEMBL519982
|
C005197
|
23 / 26 / 26 | 6 / 0 | No. 54 | No. 17 |
|
Human Protein / Gene in interactions
23 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P08069 | Insulin-like growth factor 1 receptor | TK tyrosine-protein kinase INSR subfamily | C00023663 | 1 / 3 |
| O14965 | Aurora kinase A | Aur | C00023663 | 0 / 0 |
| P68400 | Casein kinase II subunit alpha | Ck2 | C00023663 | 0 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00023663 | 0 / 0 |
| O00444 | Serine/threonine-protein kinase PLK4 | PLK serine/threonine protein kinase subfamily | C00023663 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00023663 | 1 / 8 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00023663 | 1 / 1 |
| P54760 | Ephrin type-B receptor 4 | Eph | C00023663 | 0 / 0 |
| Q05397 | Focal adhesion kinase 1 | Fak | C00023663 | 0 / 0 |
| Q02763 | Angiopoietin-1 receptor | Tie | C00023663 | 1 / 1 |
| O60285 | NUAK family SNF1-like kinase 1 | CAMK serine/threonine protein kinase NUAK subfamily | C00023663 | 0 / 0 |
| P06213 | Insulin receptor | TK tyrosine-protein kinase INSR subfamily | C00023663 | 5 / 4 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00023663 | 5 / 9 |
| P09619 | Platelet-derived growth factor receptor beta | Pdgfr | C00023663 | 5 / 1 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00023663 | 0 / 0 |
| Q96GD4 | Aurora kinase B | Aur | C00023663 | 0 / 0 |
| P35968 | Vascular endothelial growth factor receptor 2 | Vegfr | C00023663 | 1 / 0 |
| P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00023663 | 2 / 3 |
| P35916 | Vascular endothelial growth factor receptor 3 | Vegfr | C00023663 | 2 / 1 |
| P41279 | Mitogen-activated protein kinase kinase kinase 8 | Ste11 | C00023663 | 0 / 0 |
| P53350 | Serine/threonine-protein kinase PLK1 | PLK serine/threonine protein kinase subfamily | C00023663 | 0 / 0 |
| P31749 | RAC-alpha serine/threonine-protein kinase | Akt | C00023663 | 4 / 1 |
| P11802 | Cyclin-dependent kinase 4 | CMGC serine/threonine protein kinase family | C00023663 | 1 / 3 |
6 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00023663
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00023663
|
| 2938 | GSTA1, GST2, GSTA1-1, GTH1 | glutathione S-transferase alpha 1 (EC:2.5.1.18) |
C00023663
|
| 2939 | GSTA2, GST2, GSTA2-2, GTA2, GTH2 | glutathione S-transferase alpha 2 (EC:2.5.1.18) |
C00023663
|
| 4780 | NFE2L2, NRF2 | nuclear factor, erythroid 2-like 2 |
C00023663
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00023663
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (26)
| OMIM | preferred title | UniProt |
|---|---|---|
| #615007 | Basal ganglia calcification, idiopathic, 4; ibgc4 |
P09619
|
| #114480 | Breast cancer |
P31749
|
| #114500 | Colorectal cancer; crc |
P31749
|
| #615109 | Cowden syndrome 6; cws6 |
P31749
|
| #610549 | Diabetes mellitus, insulin-resistant, with acanthosis nigricans |
P06213
|
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm |
P06213
|
| #246200 | Donohue syndrome |
P06213
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #602089 | Hemangioma, capillary infantile |
P35916
P35968 |
| #114550 | Hepatocellular carcinoma |
P08581
|
| #609968 | Hyperinsulinemic hypoglycemia, familial, 5; hhf5 |
P06213
|
| #270450 | Insulin-like growth factor i, resistance to |
P08069
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
P09619
|
| #601626 | Leukemia, acute myeloid; aml |
P09619
P36888 |
| #211980 | Lung cancer |
P00533
P04626 |
| #153100 | Lymphedema, hereditary, ia |
P35916
|
| #609048 | Melanoma, cutaneous malignant, susceptibility to, 3; cmm3 |
P11802
|
| #131440 | Myeloproliferative disorder, chronic, with eosinophilia |
P09619
|
| #228550 | Myofibromatosis, infantile, 1; imf1 |
P09619
|
| #167000 | Ovarian cancer |
P04626
|
| #262190 | Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities |
P06213
|
| #176920 | Proteus syndrome |
P31749
|
| #605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
| #600195 | Venous malformations, multiple cutaneous and mucosal; vmcm |
Q02763
|
KEGG DISEASE (26)
| KEGG | name | UniProt |
|---|---|---|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
|
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P08581 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) P11802 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P09619 (related) P11802 (related) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00026 | Endometrial Cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P08581 (related) |
| H00719 | Leprechaunism |
P06213
(related)
|
| H00942 | Rabson-Mendenhall syndrome |
P06213
(related)
|
| H01228 | Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) |
P06213
(related)
|
| H01267 | Familial hyperinsulinemic hypoglycemia (HHF) |
P06213
(related)
|
| H00015 | Malignant pleural mesothelioma |
P08069
(related)
|
| H00050 | Synovial sarcoma |
P08069
(related)
|
| H01274 | Growth delay due to insulin-like growth factor I resistance |
P08069
(related)
|
| H00021 | Renal cell carcinoma |
P08581
(related)
|
| H00038 | Malignant melanoma |
P11802
(related)
|
| H00539 | PTEN hamartoma tumor syndrome (PHTS) |
P31749
(related)
|
| H00535 | Lymphedemas |
P35916
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
|
| H00531 | Venous malformations |
Q02763
(related)
|