Harziella entomophilla
Metabolite list (1)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00023944
|
Aphidicolin
/ Aphidicolane-3alpha,16,17,18-tetraol |
CHEMBL12500
CHEMBL29711 CHEMBL485469 CHEMBL2006768 |
D016590
|
11 / 24 / 14 | 7 / 2 | No. 203 | No. 41 |
|
Human Protein / Gene in interactions
11 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q16637 | Survival motor neuron protein | Unclassified protein | C00023944 | 4 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00023944 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00023944 | 11 / 10 |
| P54098 | DNA polymerase subunit gamma-1 | Enzyme | C00023944 | 6 / 2 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00023944 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00023944 | 1 / 1 |
| P09884 | DNA polymerase alpha catalytic subunit | Transferase | C00023944 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00023944 | 0 / 0 |
| P28340 | DNA polymerase delta catalytic subunit | Transferase | C00023944 | 2 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00023944 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00023944 | 0 / 0 |
7 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 890 | CCNA2, CCN1, CCNA | cyclin A2 |
C00023944
|
| 11200 | CHEK2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1 | checkpoint kinase 2 (EC:2.7.11.1) |
C00023944
|
| 3014 | H2AFX, H2A.X, H2A/X, H2AX | H2A histone family, member X |
C00023944
|
| 5591 | PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350 | protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1) |
C00023944
|
| 6256 | RXRA, NR2B1 | retinoid X receptor, alpha |
C00023944
|
| 943 | TNFRSF8, CD30, D1S166E, Ki-1 | tumor necrosis factor receptor superfamily, member 8 |
C00023944
|
| 7518 | XRCC4 | X-ray repair complementing defective repair in Chinese hamster cells 4 |
C00023944
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (24)
| OMIM | preferred title | UniProt |
|---|---|---|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #612591 | Colorectal cancer, susceptibility to, 10; crcs10 |
P28340
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #256000 | Leigh syndrome; ls |
P54098
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #615381 | Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome; mdpl |
P28340
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #203700 | Mitochondrial dna depletion syndrome 4a (alpers type); mtdps4a |
P54098
|
| #613662 | Mitochondrial dna depletion syndrome 4b (mngie type); mtdps4b |
P54098
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #157640 | Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant, 1; peoa1 |
P54098
|
| #258450 | Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive; peob |
P54098
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #607459 | Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis; sando |
P54098
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
KEGG DISEASE (14)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00469 | Mitochondrial DNA depletion syndrome (MDS) |
P54098
(related)
|
| H01118 | Progressive external ophthalmoplegia (PEO) |
P54098
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|