Species

KNApSAcK Entry

Organism name Pachygone loyaltiensis Diels
Genus Pachygone
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Pachygone loyaltiensis
Linked NCBI taxonomy ID 461615
Linked level species

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00025634 External link 512 1,2-Dehydroapateline
/ (+)-1,2-Dehydroapateline
CHEMBL390616
No. 10 No. 4
C00025637 External link 512 1,2-Dehydrotelobine
/ 1',2'-Didehydrotelobine
/ (+)-1,2-Dehydrotelobine
CHEMBL452663
No. 10 No. 4
C00025646 External link 512 Apateline
/ (+)-Apateline
/ O12'-Demethyltelobine
No. 10 No. 4
C00025670 External link 512 O-Methylcocsoline
/ (+)-Methylcocsoline
/ (+)-O-Methylcocsoline
CHEMBL1450305
CHEMBL1488591
CHEMBL2063765
28 / 23 / 17 No. 10 No. 4
C00025671 External link 512 (+)-Bisnoraromoline
/ N,N'-Bisnoraromoline
/ (+)-N,N-Bisnoraromoline
/ 2,2'-Didemethylaromoline
No. 10 No. 4
C00025914 External link 512 Isotrilobin
/ Homotrilobin
/ Homotrilobine
/ (+)-Isotrilobine
/ N,O-Dimethylcocsoline
CHEMBL503241
CHEMBL448550
No. 10 No. 4

Human Protein / Gene in interactions

28 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00025670 1 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00025670 0 / 0
Q99700 Ataxin-2 Unclassified protein C00025670 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00025670 0 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00025670 1 / 0
P39748 Flap endonuclease 1 Enzyme C00025670 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00025670 0 / 0
P42858 Huntingtin Unclassified protein C00025670 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00025670 2 / 0
O75496 Geminin Unclassified protein C00025670 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00025670 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00025670 7 / 3
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00025670 1 / 2
P83916 Chromobox protein homolog 1 Unclassified protein C00025670 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00025670 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00025670 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00025670 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00025670 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00025670 0 / 1
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00025670 1 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00025670 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00025670 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00025670 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00025670 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00025670 1 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00025670 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00025670 1 / 4
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00025670 2 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (23)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#114500 Colorectal cancer; crc P84022
Q14191
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#143100 Huntington disease; hd P42858
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277700 Werner syndrome; wrn Q14191

KEGG DISEASE (17)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)