Species

KNApSAcK Entry

Organism name Cupressus tricuspidata
Genus Cupressus
Family Cupressaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Cupressus
Linked NCBI taxonomy ID 13468
Linked level genus

Family

Family in NCBI taxonomy Cupressaceae
ID 3367

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Spermatophyta
ID 58024

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00000805 External link 512 alpha-Pinene
CHEMBL442565
C005451
3 / 3 / 2 0 / 1 No. 476 No. 35
C00003062 External link 512 beta-Thujaplicin
CHEMBL48310
C009479
27 / 27 / 50 No. 1304 No. 35
C00011962 External link 512 Nootkatin
CHEMBL1700891
6 / 1 / 1 No. 3130

Human Protein / Gene in interactions

33 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q13148 TAR DNA-binding protein 43 Unclassified protein C00003062 C00011962 1 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00003062 C00011962 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00003062 C00011962 0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00003062 2 / 0
P22894 Neutrophil collagenase M10A C00003062 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00003062 2 / 2
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00011962 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00000805 3 / 2
P11473 Vitamin D3 receptor NR1I1 C00003062 2 / 3
O15296 Arachidonate 15-lipoxygenase B Enzyme C00003062 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00003062 0 / 0
P42858 Huntingtin Unclassified protein C00003062 1 / 1
O75496 Geminin Unclassified protein C00011962 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00003062 0 / 0
P03956 Interstitial collagenase M10A C00003062 0 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00003062 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00003062 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000805 0 / 0
P08253 72 kDa type IV collagenase M10A C00003062 1 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00003062 2 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00000805 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00003062 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00003062 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003062 0 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00011962 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00003062 4 / 3
Q16637 Survival motor neuron protein Unclassified protein C00003062 4 / 1
P08254 Stromelysin-1 M10A C00003062 1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00003062 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00003062 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00003062 1 / 1
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00003062 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00003062 7 / 37

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (30)

OMIM preferred title UniProt
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114500 Colorectal cancer; crc P18054
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#119900 Digital clubbing, isolated congenital P15428
#133239 Esophageal cancer P04637
P18054
#600274 Frontotemporal dementia; ftd P10636
#143100 Huntington disease; hd P42858
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#211980 Lung cancer P04637
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (52)

KEGG name UniProt
H00028 Choriocarcinoma P03956 (related)
P04637 (related)
P08253 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P08253 (related)
P14780 (related)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00472 Torg-Winchester syndrome P08253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003877 Dermatitis, Contact C00000805