Siparuna pauciflora
Species
KNApSAcK Entry
| Organism name | Siparuna pauciflora |
|---|---|
| Genus | Siparuna |
| Family | Monimiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Siparuna pauciflora |
|---|---|
| Linked NCBI taxonomy ID | 141960 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Siparunaceae |
|---|---|
| ID | 104773 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Magnoliophyta |
|---|---|
| ID | 3398 |
Metabolite list (8)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00027150
|
Nantenine
/ (+)-Domestine / (+)-Nantenine |
CHEMBL179440
CHEMBL467094 |
C041615
|
38 / 10 / 2 | No. 20 | No. 4 |
|
|
|
C00027304
|
Boldine
/ d-Boldine / (+)-Boldine |
CHEMBL388342
CHEMBL1321247 CHEMBL1437753 |
C011686
|
34 / 32 / 35 | No. 20 | No. 4 |
|
|
|
C00027409
|
Laurotetanin
/ Laurotetanine / (+)-Laurotetanine |
CHEMBL464098
|
C008256
|
No. 20 | No. 4 |
|
||
|
C00027433
|
Laurolitsine
/ (+)-Norboldine / (+)-Laurolitsine |
CHEMBL487388
|
C109133
|
No. 20 | No. 4 |
|
||
|
C00028728
|
Noroliveroline
/ Nor-Oliveroline / (-)-Noroliveroline / (-)-Nor-Oliveroline |
CHEMBL464657
CHEMBL1618042 |
No. 553 |
|
||||
|
C00037825
|
Sipaucin A
|
No. 4928 |
|
|||||
|
C00037827
|
Sipaucin C
|
No. 4928 |
|
|||||
|
C00037826
|
Sipaucin B
/ (+)-Sipaucin B |
No. 8257 |
|
Human Protein / Gene in interactions
72 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00027304 | 1 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00027304 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00027304 | 1 / 1 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00027150 | 0 / 0 |
| Q9Y5N1 | Histamine H3 receptor | Histamine receptor | C00027150 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00027304 | 1 / 1 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00027304 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00027304 | 11 / 10 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00027150 | 0 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00027150 | 0 / 0 |
| P28222 | 5-hydroxytryptamine receptor 1B | Serotonin receptor | C00027150 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00027150 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00027150 | 1 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00027150 | 0 / 0 |
| P21918 | D(1B) dopamine receptor | Dopamine receptor | C00027150 | 1 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00027150 | 0 / 0 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00027150 | 0 / 0 |
| P47898 | 5-hydroxytryptamine receptor 5A | Serotonin receptor | C00027150 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00027304 | 0 / 1 |
| P17787 | Neuronal acetylcholine receptor subunit beta-2 | CHRN beta | C00027304 | 1 / 1 |
| P43681 | Neuronal acetylcholine receptor subunit alpha-4 | CHRN alpha | C00027304 | 1 / 1 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00027304 | 1 / 0 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00027150 | 2 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00027150 | 0 / 0 |
| P28566 | 5-hydroxytryptamine receptor 1E | Serotonin receptor | C00027150 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00027304 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00027304 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00027304 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00027304 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00027304 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00027150 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00027150 | 0 / 0 |
| P35348 | Alpha-1A adrenergic receptor | Adrenergic receptor | C00027150 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00027150 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00027150 | 0 / 0 |
| P46098 | 5-hydroxytryptamine receptor 3A | NS | C00027150 | 0 / 0 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00027150 | 0 / 0 |
| Q9H3N8 | Histamine H4 receptor | Histamine receptor | C00027150 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00027304 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00027304 | 1 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00027150 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00027150 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00027150 | 2 / 0 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00027150 | 1 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00027150 | 0 / 0 |
| P36544 | Neuronal acetylcholine receptor subunit alpha-7 | CHRN alpha | C00027304 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00027304 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00027304 | 3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00027304 | 2 / 2 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00027304 | 0 / 0 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00027150 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00027150 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00027150 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00027150 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00027150 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00027304 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00027304 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00027304 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00027304 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00027304 | 4 / 3 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00027150 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00027150 | 0 / 0 |
| P28221 | 5-hydroxytryptamine receptor 1D | Serotonin receptor | C00027150 | 0 / 0 |
| P35368 | Alpha-1B adrenergic receptor | Adrenergic receptor | C00027150 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00027150 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00027304 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00027304 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00027304 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00027304 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00027304 | 1 / 2 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00027304 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00027304 | 1 / 4 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (42)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #606798 | Blepharospasm, benign essential |
P21918
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600513 | Epilepsy, nocturnal frontal lobe, 1; enfl1 |
P43681
|
| #605375 | Epilepsy, nocturnal frontal lobe, 3; enfl3 |
P17787
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #159900 | Myoclonic dystonia |
P14416
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (37)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00807 | Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) |
P17787
(related)
P43681 (related) |
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|