Lithospermum officinale
Species
KNApSAcK Entry
| Organism name | Lithospermum officinale |
|---|---|
| Genus | Lithospermum |
| Family | Boraginaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Lithospermum officinale |
|---|---|
| Linked NCBI taxonomy ID | 475907 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Boraginaceae |
|---|---|
| ID | 21571 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Natural Activity
List (8)
| Species | Activity |
|---|---|
| Lithospermum officinale L. | Antiestrogenic |
| Lithospermum officinale L. | Antigonadotropic |
| Lithospermum officinale L. | Antithyroid |
| Lithospermum officinale L. | Contraceptive |
| Lithospermum officinale L. | Depurative |
| Lithospermum officinale L. | Diuretic |
| Lithospermum officinale L. | Litholytic |
| Lithospermum officinale L. | Sedative |
Metabolite list (1)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00000859
|
Shikonin
|
CHEMBL9470
CHEMBL29285 CHEMBL28457 |
16 / 14 / 12 | No. 2968 | No. 80 |
|
Human Protein / Gene in interactions
16 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P35610 | Sterol O-acyltransferase 1 | Enzyme | C00000859 | 0 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00000859 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00000859 | 4 / 1 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00000859 | 3 / 1 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00000859 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000859 | 2 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000859 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00000859 | 0 / 0 |
| O75908 | Sterol O-acyltransferase 2 | Enzyme | C00000859 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000859 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000859 | 4 / 3 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000859 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000859 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000859 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00000859 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00000859 | 1 / 4 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (14)
| OMIM | preferred title | UniProt |
|---|---|---|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (12)
| KEGG | name | UniProt |
|---|---|---|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|