Species

KNApSAcK Entry

Organism name Curcuma zedoaria ROSCOE
Genus Curcuma
Family Zingiberaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Curcuma
Linked NCBI taxonomy ID 99568
Linked level genus

Family

Family in NCBI taxonomy Zingiberaceae
ID 4642

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Liliopsida
ID 4447

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00032769 External link 512 bis-Demethoxycurcumin
/ bis-(4-hydroxycinnamoyl)methane
/ p,p'-Dihydroxydicinnamoyl methane
CHEMBL105350
C034786
4 / 2 / 3 18 / 4 No. 2164
C00032547 External link 512 Zedoarofuran
CHEMBL513604
No. 2696

Human Protein / Gene in interactions

4 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00032769 0 / 3
Q9UQM7 Calcium/calmodulin-dependent protein kinase type II subunit alpha Camk2 C00032769 0 / 0
P26358 DNA (cytosine-5)-methyltransferase 1 Transferase C00032769 2 / 0
Q04760 Lactoylglutathione lyase Enzyme C00032769 0 / 0

18 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00032769
1244 ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP ATP-binding cassette, sub-family C (CFTR/MRP), member 2 C00032769
351 APP, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2 amyloid beta (A4) precursor protein C00032769
2730 GCLM, GLCLR glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) C00032769
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00032769
4248 MGAT3, GNT-III, GNT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (EC:2.4.1.144) C00032769
4323 MMP14, MMP-14, MMP-X1, MT-MMP, MT-MMP_1, MT1-MMP, MT1MMP, MTMMP1, WNCHRS matrix metallopeptidase 14 (membrane-inserted) (EC:3.4.24.80) C00032769
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00032769
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00032769
1728 NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) C00032769
5328 PLAU, ATF, BDPLT5, QPD, UPA, URK, u-PA plasminogen activator, urokinase (EC:3.4.21.73) C00032769
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00032769
7077 TIMP2, CSC-21K, DDC8 TIMP metallopeptidase inhibitor 2 C00032769
7097 TLR2, CD282, TIL4 toll-like receptor 2 C00032769
7098 TLR3, CD283, IIAE2 toll-like receptor 3 C00032769
7099 TLR4, ARMD10, CD284, TLR-4, TOLL toll-like receptor 4 C00032769
7421 VDR, NR1I1 vitamin D (1,25- dihydroxyvitamin D3) receptor C00032769
7490 WT1, AWT1, EWS-WT1, GUD, NPHS4, WAGR, WIT-2, WT33 Wilms tumor 1 C00032769

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (2)

OMIM preferred title UniProt
#604121 Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant; adcadn P26358
#614116 Neuropathy, hereditary sensory, type ie; hsn1e P26358

KEGG DISEASE (3)

KEGG name UniProt
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)

Diseases related to CTD interactions

4 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000544 Alzheimer Disease C00032769
D004487 Edema C00032769
D009361 Neoplasm Invasiveness C00032769
D013276 Stomach Ulcer C00032769