Halichondria melanodocia

• Index
• Plant Species
• Metabolite list (1)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Halichondria melanodocia
Genus	Halichondria
Family	Halichondriidae
Kingdom	Animalia

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Halichondria melanadocia
Linked NCBI taxonomy ID	1183870
Linked level	species

Family

Family in NCBI taxonomy	Halichondriidae
ID	6060

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Metazoa
ID	33208

Plant class

Plant class
ID

Metabolite list (1)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00039897	Okadaic acid	CHEMBL280487 CHEMBL158524 CHEMBL1269053 CHEMBL1454935 CHEMBL1613688 CHEMBL1728497 CHEMBL2006105 CHEMBL2068811 CHEMBL2304065	D019319	18 / 28 / 46	77 / 5	No. 3072

Human Protein / Gene in interactions

18 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00039897	0 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00039897	7 / 37
Q99700	Ataxin-2	Unclassified protein	C00039897	1 / 1
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00039897	2 / 0
Q15172	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform	Protein phosphatase regulatory subunit	C00039897	0 / 0
P37840	Alpha-synuclein	Unclassified protein	C00039897	4 / 2
O75688	Protein phosphatase 1B	Ser_Thr	C00039897	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00039897	2 / 0
O75496	Geminin	Unclassified protein	C00039897	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00039897	7 / 3
P36873	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	Ser_Thr	C00039897	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00039897	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00039897	0 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00039897	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00039897	4 / 3
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00039897	0 / 0
P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	Ser_Thr	C00039897	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00039897	1 / 0

77 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00039897
226	ALDOA, ALDA, GSD12	aldolase A, fructose-bisphosphate (EC:4.1.2.13)	C00039897
498	ATP5A1, ATP5A, ATP5AL2, ATPM, MC5DN4, MOM2, OMR, ORM, hATP1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	C00039897
513	ATP5D	ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit (EC:3.6.1.14)	C00039897
581	BAX, BCL2L4	BCL2-associated X protein	C00039897
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00039897
27101	CACYBP, GIG5, RP1-102G20.6, S100A6BP, SIP	calcyclin binding protein	C00039897
843	CASP10, ALPS2, FLICE2, MCH4	caspase 10, apoptosis-related cysteine peptidase (EC:3.4.22.63)	C00039897
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00039897
840	CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3	caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60)	C00039897
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00039897
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00039897
8900	CCNA1	cyclin A1	C00039897
9133	CCNB2, HsT17299	cyclin B2	C00039897
983	CDK1, CDC2, CDC28A, P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	C00039897
1017	CDK2, p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	C00039897
1072	CFL1, CFL	cofilin 1 (non-muscle)	C00039897
1080	CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49)	C00039897
54927	CHCHD3, MINOS3, PPP1R22	coiled-coil-helix-coiled-coil-helix domain containing 3	C00039897
1139	CHRNA7, CHRNA7-2, NACHRA7	cholinergic receptor, nicotinic, alpha 7 (neuronal)	C00039897
1141	CHRNB2, EFNL3, nAChRB2	cholinergic receptor, nicotinic, beta 2 (neuronal)	C00039897
1207	CLNS1A, CLCI, CLNS1B, ICln	chloride channel, nucleotide-sensitive, 1A	C00039897
1312	COMT	catechol-O-methyltransferase (EC:2.1.1.6)	C00039897
1387	CREBBP, CBP, KAT3A, RSTS	CREB binding protein (EC:2.3.1.48)	C00039897
1499	CTNNB1, CTNNB, MRD19, armadillo	catenin (cadherin-associated protein), beta 1, 88kDa	C00039897
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00039897
1601	DAB2, DOC-2, DOC2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	C00039897
10521	DDX17, P72, RH70	DEAD (Asp-Glu-Ala-Asp) box helicase 17 (EC:3.6.4.13)	C00039897
11034	DSTN, ACTDP, ADF, bA462D18.2	destrin (actin depolymerizing factor)	C00039897
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00039897
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00039897
2739	GLO1, GLOD1, GLYI	glyoxalase I (EC:4.4.1.5)	C00039897
2932	GSK3B	glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)	C00039897
3315	HSPB1, CMT2F, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27	heat shock 27kDa protein 1	C00039897
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00039897
3717	JAK2, JTK10, THCYT3	Janus kinase 2 (EC:2.7.10.2)	C00039897
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00039897
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00039897
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00039897
5598	MAPK7, BMK1, ERK4, ERK5, PRKM7	mitogen-activated protein kinase 7 (EC:2.7.11.24)	C00039897
4137	MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU	microtubule-associated protein tau	C00039897
5469	MED1, CRSP1, CRSP200, DRIP205, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2	mediator complex subunit 1	C00039897
23184	MESDC2, BOCA, MESD	mesoderm development candidate 2	C00039897
4625	MYH7, CMD1S, CMH1, MPD1, MYHCB, SPMD, SPMM	myosin, heavy chain 7, cardiac muscle, beta	C00039897
54187	NANS, SAS	N-acetylneuraminic acid synthase (EC:2.5.1.56 2.5.1.57)	C00039897
9611	NCOR1, N-CoR, N-CoR1, TRAC1, hN-CoR	nuclear receptor corepressor 1	C00039897
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00039897
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00039897
4830	NME1, AWD, GAAD, NB, NBS, NDKA, NDPK-A, NDPKA, NM23, NM23-H1	NME/NM23 nucleoside diphosphate kinase 1 (EC:2.7.4.6)	C00039897
8856	NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR	nuclear receptor subfamily 1, group I, member 2	C00039897
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00039897
5093	PCBP1, HNRPE1, HNRPX, hnRNP-E1, hnRNP-X	poly(rC) binding protein 1	C00039897
5110	PCMT1, PIMT	protein-L-isoaspartate (D-aspartate) O-methyltransferase (EC:2.1.1.77)	C00039897
3651	PDX1, GSF, IDX-1, IPF1, IUF1, MODY4, PDX-1, STF-1	pancreatic and duodenal homeobox 1	C00039897
5223	PGAM1, PGAM-B, PGAMA	phosphoglycerate mutase 1 (brain) (EC:3.1.3.13 5.4.2.4 5.4.2.11)	C00039897
5241	PGR, NR3C3, PR	progesterone receptor	C00039897
5465	PPARA, NR1C1, PPAR, PPARalpha, hPPAR	peroxisome proliferator-activated receptor alpha	C00039897
5478	PPIA, CYPA, CYPH	peptidylprolyl isomerase A (cyclophilin A) (EC:5.2.1.8)	C00039897
5499	PPP1CA, PP-1A, PP1A, PP1alpha, PPP1A	protein phosphatase 1, catalytic subunit, alpha isozyme (EC:3.1.3.16)	C00039897
5515	PPP2CA, PP2Ac, PP2CA, PP2Calpha, RP-C	protein phosphatase 2, catalytic subunit, alpha isozyme (EC:3.1.3.16)	C00039897
5518	PPP2R1A, PP2A-Aalpha, PP2AAALPHA, PR65A	protein phosphatase 2, regulatory subunit A, alpha (EC:3.1.3.16)	C00039897
25824	PRDX5, ACR1, AOEB166, B166, PLP, PMP20, PRDX6, PRXV, prx-V	peroxiredoxin 5 (EC:1.11.1.15)	C00039897
9588	PRDX6, 1-Cys, AOP2, NSGPx, PRX, aiPLA2, p29	peroxiredoxin 6 (EC:1.11.1.9 1.11.1.15)	C00039897
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00039897
5933	RBL1, CP107, PRB1, p107	retinoblastoma-like 1 (p107)	C00039897
5934	RBL2, P130, Rb2	retinoblastoma-like 2 (p130)	C00039897
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00039897
6206	RPS12, S12	ribosomal protein S12	C00039897
6256	RXRA, NR2B1	retinoid X receptor, alpha	C00039897
6406	SEMG1, CT103, SEMG, SGI, dJ172H20.2	semenogelin I	C00039897
6647	SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer	superoxide dismutase 1, soluble (EC:1.15.1.1)	C00039897
6648	SOD2, IPOB, MNSOD, MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	C00039897
7018	TF, PRO1557, PRO2086, TFQTL1	transferrin	C00039897
8743	TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL	tumor necrosis factor (ligand) superfamily, member 10	C00039897
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00039897
7295	TXN, TRDX, TRX, TRX1	thioredoxin	C00039897
7421	VDR, NR1I1	vitamin D (1,25- dihydroxyvitamin D3) receptor	C00039897

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions