Species

KNApSAcK Entry

Organism name Podocarpus totara L.
Genus Podocarpus
Family Podocarpaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Podocarpus
Linked NCBI taxonomy ID 3363
Linked level genus

Family

Family in NCBI taxonomy Podocarpaceae
ID 3362

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Spermatophyta
ID 58024

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00040508 External link 512 Totarol
/ (+)-Totarol
CHEMBL487602
CHEMBL1474684
CHEMBL1999971
C078548
20 / 19 / 47 No. 359 No. 40

Human Protein / Gene in interactions

20 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P04637 Cellular tumor antigen p53 Transcription Factor C00040508 7 / 37
Q99700 Ataxin-2 Unclassified protein C00040508 1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00040508 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00040508 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00040508 2 / 0
O75496 Geminin Unclassified protein C00040508 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00040508 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00040508 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00040508 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00040508 0 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00040508 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00040508 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00040508 0 / 0
P07900 Heat shock protein HSP 90-alpha Other cytosolic protein C00040508 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00040508 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00040508 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00040508 1 / 0
O00255 Menin Unclassified protein C00040508 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00040508 1 / 2
Q13148 TAR DNA-binding protein 43 Unclassified protein C00040508 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (19)

OMIM preferred title UniProt
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114500 Colorectal cancer; crc P84022
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (47)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)