Species

KNApSAcK Entry

Organism name Filifolium sibiricum
Genus Filifolium
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Artemisia sibirica
Linked NCBI taxonomy ID 217469
Linked level species

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00000960 External link 512 Eriodictyol
CHEMBL8996
CHEMBL307893
CHEMBL1975989
C007619
32 / 29 / 55 5 / 0 No. 25 No. 14

Human Protein / Gene in interactions

32 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P04637 Cellular tumor antigen p53 Transcription Factor C00000960 7 / 37
P14618 Pyruvate kinase PKM Enzyme C00000960 0 / 0
P06746 DNA polymerase beta Enzyme C00000960 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00000960 1 / 1
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00000960 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00000960 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000960 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00000960 1 / 1
P39748 Flap endonuclease 1 Enzyme C00000960 0 / 0
O75496 Geminin Unclassified protein C00000960 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00000960 1 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme C00000960 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00000960 3 / 1
P11021 78 kDa glucose-regulated protein Unclassified protein C00000960 0 / 0
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00000960 4 / 4
P28482 Mitogen-activated protein kinase 1 Erk C00000960 0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme C00000960 0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000960 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000960 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000960 2 / 2
P22303 Acetylcholinesterase Hydrolase C00000960 1 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00000960 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000960 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00000960 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00000960 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000960 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000960 4 / 3
Q9UBT6 DNA polymerase kappa Enzyme C00000960 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000960 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00000960 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00000960 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00000960 2 / 1

5 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00000960
2950 GSTP1, DFN7, FAEES3, GST3, GSTP, PI glutathione S-transferase pi 1 (EC:2.5.1.18) C00000960
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00000960
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00000960
29110 TBK1, NAK, T2K TANK-binding kinase 1 (EC:2.7.11.1) C00000960

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (29)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114500 Colorectal cancer; crc Q14191
#119900 Digital clubbing, isolated congenital P15428
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#232300 Glycogen storage disease ii P10253
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#601626 Leukemia, acute myeloid; aml P36888
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#211980 Lung cancer P04637
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (55)

KEGG name UniProt
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00213 Hypophosphatasia P05186 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)