Brickellia vernicosa
Species
KNApSAcK Entry
| Organism name | Brickellia vernicosa |
|---|---|
| Genus | Brickellia |
| Family | Asteraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Brickellia |
|---|---|
| Linked NCBI taxonomy ID | 102753 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Asteraceae |
|---|---|
| ID | 4210 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (5)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00005665
|
Eupatolin
|
No. 2 | No. 15 |
|
||||
|
C00005327
|
Eupalin
|
CHEMBL483203
CHEMBL1985417 |
No. 2 | No. 15 |
|
|||
|
C00005640
|
Patuletin 3-rhamnoside
|
No. 2 | No. 15 |
|
||||
|
C00005639
|
Patuletin 3-glucoside
/ Patuletin 3-O-beta-D-glucoside |
CHEMBL483837
CHEMBL2037045 |
No. 2 | No. 15 |
|
|||
|
C00000968
|
Hesperetin
|
CHEMBL88169
CHEMBL399121 CHEMBL1589200 |
C013015
|
42 / 50 / 65 | 18 / 3 | No. 25 | No. 14 |
|
Human Protein / Gene in interactions
42 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000968 | 1 / 0 |
| P14061 | Estradiol 17-beta-dehydrogenase 1 | Enzyme | C00000968 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00000968 | 7 / 37 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00000968 | 4 / 1 |
| Q99700 | Ataxin-2 | Unclassified protein | C00000968 | 1 / 1 |
| P14618 | Pyruvate kinase PKM | Enzyme | C00000968 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00000968 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00000968 | 0 / 0 |
| Q13315 | Serine-protein kinase ATM | Atypical serine/threonine protein kinase PIKK subfamily | C00000968 | 1 / 4 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000968 | 3 / 2 |
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00000968 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000968 | 0 / 1 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00000968 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000968 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00000968 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00000968 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00000968 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00000968 | 4 / 2 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00000968 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000968 | 0 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00000968 | 5 / 3 |
| Q16678 | Cytochrome P450 1B1 | Cytochrome P450 1B1 | C00000968 | 4 / 4 |
| P04745 | Alpha-amylase 1 | Enzyme | C00000968 | 0 / 0 |
| Q13133 | Oxysterols receptor LXR-alpha | NR1H3 | C00000968 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000968 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000968 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000968 | 3 / 3 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00000968 | 2 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000968 | 2 / 2 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00000968 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00000968 | 0 / 0 |
| P02647 | Apolipoprotein A-I | Unclassified protein | C00000968 | 3 / 2 |
| P22303 | Acetylcholinesterase | Hydrolase | C00000968 | 1 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00000968 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000968 | 1 / 1 |
| P37059 | Estradiol 17-beta-dehydrogenase 2 | Enzyme | C00000968 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000968 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00000968 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000968 | 4 / 3 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00000968 | 0 / 0 |
| P37173 | TGF-beta receptor type-2 | TKL dual-specificity kinase STKR type 2 subfamily | C00000968 | 4 / 3 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00000968 | 1 / 0 |
18 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00000968
|
| 10257 | ABCC4, EST170205, MOAT-B, MOATB, MRP4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 |
C00000968
|
| 10057 | ABCC5, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 |
C00000968
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00000968
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00000968
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00000968
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00000968
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00000968
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00000968
|
| 1017 | CDK2, p33(CDK2) | cyclin-dependent kinase 2 (EC:2.7.11.22) |
C00000968
|
| 1019 | CDK4, CMM3, PSK-J3 | cyclin-dependent kinase 4 (EC:2.7.11.22) |
C00000968
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00000968
|
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
C00000968
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00000968
|
| 1588 | CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM | cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00000968
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00000968
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00000968
|
| 7402 | UTRN, DMDL, DRP, DRP1 | utrophin |
C00000968
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (50)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #105200 | Amyloidosis, familial visceral |
P02647
|
| #208900 | Ataxia-telangiectasia; at |
Q13315
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| %606641 | Body mass index; bmi |
P37231
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #614331 | Colorectal cancer, hereditary nonpolyposis, type 6; hnpcc6 |
P37173
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #133239 | Esophageal cancer |
P04637
P37173 |
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137750 | Glaucoma 1, open angle, a; glc1a |
Q16678
|
| #231300 | Glaucoma 3, primary congenital, a; glc3a |
Q16678
|
| #137760 | Glaucoma, primary open angle; poag |
Q16678
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P37231 |
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #604091 | Hypoalphalipoproteinemia, primary |
P02647
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #610168 | Loeys-dietz syndrome, type 1b; lds1b |
P37173
|
| #610380 | Loeys-dietz syndrome, type 2b; lds2b |
P37173
|
| #211980 | Lung cancer |
P04637
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #601665 | Obesity |
P37231
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #604229 | Peters anomaly |
Q16678
|
| #172700 | Pick disease of brain |
P10636
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #205400 | Tangier disease; tgd |
P02647
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (65)
| KEGG | name | UniProt |
|---|---|---|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00845 | Familial amyloidosis |
P02647
(related)
|
| H00930 | Hypoalphalipoproteinemia |
P02647
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
Q13315 (related) |
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) P37173 (related) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00800 | Loeys-Dietz syndrome (LDS) |
P37173
(related)
|
| H00801 | Familial thoracic aortic aneurysm and dissection (TAAD) |
P37173
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
| H00064 | Ataxia telangiectasia (AT) |
Q13315
(related)
|
| H00094 | DNA repair defects |
Q13315
(related)
|
| H00848 | Ataxia with ocular apraxia (AOA) |
Q13315
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00612 | Primary open angle glaucoma |
Q16678
(related)
|
| H01075 | Peters anomaly |
Q16678
(related)
|
| H01159 | Anterior segment dysgenesis (ASD) |
Q16678
(related)
|
| H01203 | Primary congenital glaucoma (PCG) |
Q16678
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|