Species

KNApSAcK Entry

Organism name Salvia tomentosa
Genus Salvia
Family Labiatae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Salvia tomentosa
Linked NCBI taxonomy ID 1132405
Linked level species

Family

Family in NCBI taxonomy Lamiaceae
ID 4136

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (11)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00004377 External link 512 6-Hydroxyluteolin 5-glucoside
No. 2 No. 15
C00004400 External link 512 Nepitrin
/ Nepetin 7-glucoside
/ 6-Methoxyluteolin 7-glucoside
CHEMBL517682
C035839
No. 2 No. 15
C00004386 External link 512 6-Hydroxyluteolin 7-O-beta-glucopyranoside:6-Hydroxyluteolin 7-glucoside
CHEMBL469621
No. 2 No. 15
C00001036 External link 512 Diosmetin
/ 4'-Methylluteolin
/ 5,7,3'-Trihydroxy-4'-methoxyflavone
CHEMBL90568
C039602
11 / 12 / 8 5 / 0 No. 3 No. 15
C00003837 External link 512 Cirsimaritin
CHEMBL348436
C007072
13 / 18 / 14 No. 3 No. 15
C00003890 External link 512 Jaceosidin
/ 5,7,4'-Trihydroxy-6,3'-dimethoxyflavone
CHEMBL487601
C477508
1 / 0 / 0 No. 3 No. 15
C00003845 External link 512 Eupatilin
/ 2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one
CHEMBL312750
C045325
15 / 7 / 2 No. 3 No. 15
C00013595 External link 512 Eupatrin
/ Anisomelin
/ Fastigenin
/ Cirsilineol
/ 5,4'-Dihydroxy-6,7,3'-trimethoxyflavone
CHEMBL487213
C057618
No. 3 No. 15
C00003898 External link 512 5-Hydroxy-6,7,3',4'-tetramethoxyflavone
/ 6-Hydroxyluteolin 6,7,3',4'-tetramethyl ether
/ 2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7-dimethoxy-4H-1-benzopyran-4-one
CHEMBL226508
C045324
No. 8 No. 15
C00036020 External link 512 7-Acetylhorminone
/ 7alpha-Acetoxyroyleanone
CHEMBL516119
No. 792 No. 40
C00036123 External link 512 Horminone
/ 7alpha-Hydroxyroyleanone
CHEMBL517846
CHEMBL1969546
C045490
No. 792 No. 40

Human Protein / Gene in interactions

40 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P33527 Multidrug resistance-associated protein 1 drugs C00001036 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00003837 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00003837 0 / 3
P33765 Adenosine receptor A3 Adenosine receptor C00003837 0 / 0
P06746 DNA polymerase beta Enzyme C00003837 0 / 0
P04062 Glucosylceramidase Enzyme C00003837 6 / 4
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00001036 0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00001036 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00003837 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00003837 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00003837 7 / 3
Q9Y253 DNA polymerase eta Enzyme C00003837 1 / 1
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00001036 5 / 3
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00001036 4 / 4
P04745 Alpha-amylase 1 Enzyme C00001036 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001036 0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00001036 2 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein C00001036 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00003837 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00003837 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001036 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00003837 4 / 3
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00001036 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00003837 0 / 0
P59538 Taste receptor type 2 member 31 Taste receptor (taste family GPCR) C00003890 0 / 0
Q13748 Tubulin alpha-3C/D chain Structural C00003845 0 / 0
P68366 Tubulin alpha-4A chain Structural C00003845 0 / 0
Q9H4B7 Tubulin beta-1 chain Structural C00003845 1 / 0
P04350 Tubulin beta-4A chain Structural C00003845 2 / 0
Q3ZCM7 Tubulin beta-8 chain Structural C00003845 0 / 0
P07437 Tubulin beta chain Structural C00003845 0 / 0
Q71U36 Tubulin alpha-1A chain Structural C00003845 1 / 1
P68371 Tubulin beta-4B chain Structural C00003845 0 / 0
Q13509 Tubulin beta-3 chain Structural C00003845 2 / 1
P68363 Tubulin alpha-1B chain Unclassified protein C00003845 0 / 0
Q13885 Tubulin beta-2A chain Structural C00003845 0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein C00003845 0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein C00003845 0 / 0
Q9BUF5 Tubulin beta-6 chain Structural C00003845 0 / 0
Q9BVA1 Tubulin beta-2B chain Structural C00003845 1 / 0

5 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00001036
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001036
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00001036
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00001036
1577 CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3 cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) C00001036

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (37)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#614490 Blood group, junior system; jr Q9UNQ0
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#237500 Dubin-johnson syndrome; djs Q92887
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 P37231
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#611603 Lissencephaly 3; lis3 Q71U36
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#174800 Mccune-albright syndrome; mas P63092
#601665 Obesity P37231
#166350 Osseous heteroplasia, progressive; poh P63092
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (24)

KEGG name UniProt
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)